Risk factors of in-stent restenosis in patients with diabetes mellitus after percutaneous coronary intervention

Abstract

Background: Percutaneous coronary intervention (PCI) has become one of the effective methods for the treatment of coronary heart disease (CHD). However, it is easy to have in-stent restenosis (ISR), even cardiovascular events after PCI, which affects the therapeutic effects. The incidence of ISR in diabetes mellitus (DM) patients increased by 2 to 4 times. Early identification of the risk factors of ISR in DM patients after PCI may help clinical staff to prevent and intervene as soon as possible, so it is very important to improve the clinical outcomes of DM patients. Although scholars at home and abroad have studied and summarized the risk factors of ISR in DM patients after PCI, the conclusions are different. Therefore, in this study, meta-analysis was used to summarize the risk factors of ISR in DM patients after PCI, and to explore the characteristics of high-risk groups of ISR, thus providing reference for early identification and prevention of ISR. Methods: We will search related literature from PubMed, Embase, Cochrane Library, Web of Science, China Biology Medicine Database, China National Knowledge Infrastructure, China Science and Technology Journal Database, and Wanfang Database. Eligible studies will be screened based on inclusion criteria. Meanwhile, data extraction, risk of bias assessment, publication bias assessment, subgroup analysis, and quality assessment will be performed. Review Manager Version 5.3 software will be applied for data analysis. Each process is independently conducted by 2 researchers. If there is any objection, it will be submitted to a third researcher for resolution. Results: We will disseminate the findings of this systematic review and meta-analysis via publications in peer-reviewed journals. Conclusions: The results of this analysis can be used to generate a risk prediction model and provide an intervention strategy for the occurrence of ISR in DM patients after PCI. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/WC87Y.

Single-nucleotide polymorphism of ADRβ2 and CDKN1B genes in Egyptian patients with coronary artery in-stent restenosis

“…The most consistent clinical parameter that increases the risk of restenosis is diabetes [27]. Patients with insulin-dependent diabetes are at particularly high risk for adverse events following PCI.…”

Advantages and prospects of optical coherence tomography in interventional therapy of coronary heart disease (Review)

“…An OCT study determined through multiple regression analysis that low-density lipoprotein-cholesterol levels >70 mg/dl, smoking and chronic kidney disease are risk factors that promote the occurrence of new plaques. By contrast, angiotensin-converting enzyme inhibitors are effective defense pathways that prevent the occurrence of new plaques ( 63 ). Therefore, this type of drug may inhibit the formation of neoatherosclerosis plaques to a certain extent.…”

Diabetes and restenosis

“…Moreover, remnant-like particle cholesterol was shown to be an independent risk factor for ISR [ 58 ], whereas high-density lipoprotein (HDL) cholesterol levels are known to be inversely associated with ISR in diabetic patients [ 59 ]. Other predictors of ISR include levels of soluble receptor for advanced glycation end products (sRAGE), uric acid, and platelet distribution width [ 60 – 63 ].…”