Risk factors of acute blood transfusion reactions in pediatric patients in Sanglah General Hospital, Bali-Indonesia

Apriastini, Ni Komang Tri; Ariawati, Ketut

doi:10.15562/bmj.v6i3.630

Cited by 9 publications

(12 citation statements)

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“…The higher percentage of males with transfusion reactions compared to females in this study was in line with research by Apriastini et al, which found 65 males of a total of 107 subjects. A similar result was obtained in the study by Samsiar et al, which found 14,16 138 (51.5%) males from 268 subjects.…”

Section: Resultssupporting

confidence: 90%

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Identification of Risk Factors Characteristics of Transfusion Reaction

Rahajeng

Samad

Muhiddin

2020

Indonesian J. Clin. Pathol. Med. Lab.

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Blood transfusion is an important part of health care. A blood transfusion can be carried out after careful consideration of its risks and benefits. One of the important considerations for blood transfusion is adverse transfusion reaction. Several risk factors for a transfusion reaction are age, gender, repeated transfusion, disease diagnosis, type of blood component, and blood incompatibility. This research is a descriptive study performed at Blood Bank Dr. Wahidin Sudirohusodo Hospital, Makassar, from January to December 2017. The subjects were all patients reported to have an acute transfusion, totaling 104 subjects. The descriptive method was carried out by the calculation of frequency distribution. From January to December 2017, 104 patients with transfusion reactions were obtained, predominantly were male (53.8%), with the lowest age range of ≥ 60 years (27.9%), packed red cell as the most found blood components (82.4%), a history of previous transfusion reactions (72.1%), and a diagnosis of malignancy (53.9%). The history of repeated transfusions is the most common risk factor compared to age, gender, blood component, and patient diagnosis.

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Section: Resultssupporting

confidence: 90%

“…This is because the PRC component is the transfusion with the highest demand in the Blood Bank of Dr. Wahidin Sudirohusodo Hospital. Contrastingly, only 1% of WB transfusion was found in this study due to a 14,19 lack of demand.…”

Section: Resultscontrasting

confidence: 84%

Identification of Risk Factors Characteristics of Transfusion Reaction

Rahajeng

Samad

Muhiddin

2020

Indonesian J. Clin. Pathol. Med. Lab.

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“…This was in line with previously established studies in south Iran [ 76 ], Philippines [ 77 ], Ghana [ 78 ] and Egypt [ 79 ]. Another study also reported that females were less likely to be positive for HBV [ 80 ]. Almost 95% of HBV infected persons clear HBV by developing a protective Hepatitis B Surface Antibody (HBsAb) when HBV infection is acquired during adulthood, and only 5 to 10% of HBV infected persons will develop a persistent infection.…”

Section: Discussionmentioning

confidence: 99%

Sero-epidemiology and associated factors of HIV, HBV, HCV and syphilis among blood donors in Ethiopia: a systematic review and meta-analysis

et al. 2021

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Background Transfusion transmissible infections (TTIs) remain a major public health problem in developing countries including Ethiopia. In Ethiopia, comprehensive information about sero-epidemiology of major TTIs is lacking at the national level. Therefore, this systematic review and meta-analysis was aimed at providing the pooled estimate of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis among blood donors in Ethiopia. Methods Relevant studies published until May 31, 2019 were searched through PubMed/Medline, EMBASE, SCOPUS, HINARI, Cochrane database library, Web of Science, Google Scholar and Google. The methodological quality of articles was assessed using Joanna Brigg’s Institute critical appraisal checklist for prevalence and analytical studies. The pooled sero-epidemiology of HIV, HBV, HCV and syphilis were determined using the random-effects model. Heterogeneity between the studies was assessed using the I2 statistics. Publication bias was assessed by visual inspection of the funnel plot and Egger's statistics. Results A total of 7921 articles were retrieved, and 7798 were screened for eligibility after duplicates removed. Forty-nine full-text articles were assessed for eligibility; of which 45 were eligible for qualitative and quantitative synthesis: categorized as 36, 34, 31 and 23 studies for estimations of HBV, HIV, HCV and syphilis, respectively. In the random-effects model, the pooled sero-epidemiology of HBV, HIV, HCV and syphilis was 5.20, 2.83, 0.93 and 1.50%, respectively. Moreover, being a male blood donor was significantly associated with HBV and syphilis infection, whereas being a replacement blood donor was significantly associated with a high burden of HIV, HBV and HCV infections. Conclusion The pooled sero-epidemiology of major TTIs among blood donors was high. Therefore, there is a need to design prevention and control strategies in a comprehensive approach to reduce the burden.

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“…9,10 These reactions may happen as an immune response to the blood cell antigens or as a non-immune response caused by a circulation overload, transfusion siderosis, or transmission of infections. 11 The type and severity of transfusion reactions vary with the transfused blood product, the clinical condition of the recipient, past medical history and age of the recipient. 12,14 They are 1000 times more likely to occur than blood transfusion infection complications.…”

Section: Introductionmentioning

confidence: 99%

<p>Proportion of Acute Transfusion Reaction and Associated Factors Among Adult Transfused Patients at Felege Hiwot Compressive Referral Hospital, Bahir Dar, Northwest Ethiopia: A Cross-Sectional Study</p>

Gelaw¹,

Woldu²,

Melku³

2020

JBM

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Introduction: Acute transfusion reactions are adverse events occurring within 24 hrs of transfusion and cause simple-to-severe complications. They may vary with the blood component transfused and recipient factors. In Ethiopia, there is a limited evidence about the incidence and associated factors of transfusion reactions. Objective: To determine the proportion of acute transfusion reactions and associated factors among adult transfused patients. Methods: A total of 384 study participants were included in the study. Structured questionnaires were used for socio-demographic and past medical history data collection. Vital signs were measured as a baseline for every study participants and monitored and followed for 24 hrs. Laboratory tests like complete blood count, direct anti-human globulin test and urine hemoglobin were done as a baseline for suspected patients. Cross-match, blood grouping, and blood culture for patients and donors sample were also done for suspected patients. Descriptive statistics, bivariable and multivariable binary logistic regression were analyzed using SPSS version 20. P-value of <0.05 in the multivariable model was considered as statistically significant. Results: Acute transfusion reactions were observed in 5.2% of patients. Of total cases of acute transfusion reaction, the majority developed allergic reactions (65%) and febrile non-hemolytic transfusion reaction (30%). It was significantly associated with transfusion history (AOR=3.4; 95% CI: 1.2-9.7), abortion history (AOR=5.0; 95% CI: 1.5-16.4), longer blood storage time (AOR=5.1; 95% CI: 1.7-15.2) and receiving three or more unit of blood (AOR= 4.1; 95% CI: 1.5-11.2). Conclusion: Acute transfusion reactions were observed in 5.2% of patients (allergic reactions (65%), febrile non-hemolytic transfusion reaction (30%) and alloimmunization (5%)). Patients with a history of transfusion, abortion, transfused with blood stored ≥14 days and multi-transfused patients should be closely monitored.

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Risk factors of acute blood transfusion reactions in pediatric patients in Sanglah General Hospital, Bali-Indonesia

Cited by 9 publications

References 0 publications

Identification of Risk Factors Characteristics of Transfusion Reaction

Identification of Risk Factors Characteristics of Transfusion Reaction

Sero-epidemiology and associated factors of HIV, HBV, HCV and syphilis among blood donors in Ethiopia: a systematic review and meta-analysis

<p>Proportion of Acute Transfusion Reaction and Associated Factors Among Adult Transfused Patients at Felege Hiwot Compressive Referral Hospital, Bahir Dar, Northwest Ethiopia: A Cross-Sectional Study</p>

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