Risk factors for vertical transmission of Chagas disease: A systematic review and meta-analysis

Klein, Melissa; Proaño, Alvaro; Noazin, Sassan; Sciaudone, Michael; Gilman, Robert H.; Bowman, Natalie M.

doi:10.1016/j.ijid.2021.02.074

Cited by 18 publications

(18 citation statements)

References 42 publications

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“…Similar results were found in this study, in which only five patients knew they were infected. In women of childbearing age, it is important to screen for Chagas disease and treat seropositive women, as it has been shown to reduce the chances of transmission to their offspring [ 26 ]. In the same vein, tests should be carried out on children born to seropositive mothers in order to detect and treat those infected early [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Chagas Disease: Seroprevalence and Associated Factors in Indigenous Communities of the Southern Limit of Argentine Chaco

et al. 2023

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Chagas disease is more prevalent in socially vulnerable communities in the Gran Chaco Eco-region. The study evaluated the seroprevalence of Chagas disease and associated factors between May 2014 and September 2015, in indigenous communities of Santa Fe, Argentina, in the southern Chaco. Lysate ELISA and indirect hemagglutination tests were used to detect antibodies against Trypanosoma cruzi, and recombinant ELISA was used in the case of disagreement. Household surveys were conducted with the head of household about risk factors for the disease. Serological tests were conducted on 298 people from three indigenous communities, 127 male and 171 female. Seroprevalence was 18.5%. A total of 64 surveys were conducted; 82.8% of the heads of household were male, with a median age of 39 years, and 61.0% had not completed primary school. In 35.9% of the households, there was at least one member of the cohabiting group infected with T. cruzi. The level of education of the head of household showed a statistically significant association with Chagas disease (OR = 3.43), among all the risk factors studied. The prevalence of infection is lower than that of other indigenous communities of the Gran Chaco, probably because environmental conditions are moderating and disfavoring the establishment of the insect vector in homes, but also because of socioeconomic differences with the rest of the eco-region. Beyond this, serological controls are needed to prevent vertical transmission.

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Section: Discussionmentioning

confidence: 99%

Chagas Disease: Seroprevalence and Associated Factors in Indigenous Communities of the Southern Limit of Argentine Chaco

et al. 2023

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“…Considering the hyperendemicity of domestic triatomine species in this region [ 19 , 31 ], the high prevalence of acute pediatric cases diagnosed by the Ministry of Health [ 10 ], and the study’s finding of dog species present in home increasing risk (as a known risk factor for vector-human transmission cycles [ 24 , 33 , 34 ]), one would determine that a mixture of both transmission sources is responsible. As previously highlighted [ 11 , 35 ], the need for Chagas disease surveillance in pediatrics and women of childbearing age is warranted. The low number of Chagas disease seropositive children was a potential limitation, and future studies should validate these findings.…”

Section: Discussionmentioning

confidence: 99%

Elevated Pediatric Chagas Disease Burden Complicated by Concomitant Intestinal Parasites and Malnutrition in El Salvador

et al. 2021

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The eradication of the vector Rhodnius prolixus from Central America was heralded as a victory for controlling transmission of Trypanosoma cruzi, the parasite that causes Chagas disease. While public health officials believed this milestone achievement would effectively eliminate Chagas disease, case reports of acute vector transmission began amassing within a few years. This investigation employed a cross-sectional serosurvey of children either presenting with fever for clinical care or children living in homes with known triatomine presence in the state of Sonsonate, El Salvador. Over the 2018 calendar year, a 2.3% Chagas disease seroprevalence among children with hotspot clustering in Nahuizalco was identified. Positive serology was significantly associated with dogs in the home, older participant age, and a higher number of children in the home by multivariate regression. Concomitant intestinal parasitic infection was noted in a subset of studied children; 60% having at least one intestinal parasite and 15% having two or more concomitant infections. Concomitant parasitic infection was statistically associated with an overall higher parasitic load detected in stool by qPCR. Lastly, a four-fold higher burden of stunting was identified in the cohort compared to the national average, with four-fifths of mothers reporting severe food insecurity. This study highlights that polyparasitism is common, and a systems-based approach is warranted when treating Chagas disease seropositive children.

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“…Transmission is produced through hematophagous insects belonging to Reduviidae family, but also occurs via blood transfer, organ transplant, shared use of syringes, orally by ingest of contaminated food or beverages and by maternal vertical transmission. nowadays, CD has expanded to non-endemic countries as a consequence of the migration of infected individuals [ 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of the in vitro and in vivo antitrypanosomal activity of 2-styrylquinolines

Espinosa

Robledo

Guzmán

et al. 2021

Heliyon

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In this study, we report the synthesis and evaluation of in vitro and in vivo antitrypanosomal activity of styrylquinoline-like compounds (SQ) 3a-h . Synthesis was carried out by using quinaldine and 8- hydroxyquinaldine with a variety of aromatic aldehydes. The structure of SQs was corroborated by one and two-dimension NMR spectroscopy. In vitro antitrypanosomal activity on T. cruzi Talahuen strain was evaluated using β-galactosidase enzymatic method; cytotoxicity on U-937 cells was assessed by using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] method. On the other hand, in vivo therapeutical response to 3a-f compounds was evaluated in BALB/c mice ( Mus musculus ) experimentally infected with T. cruzi blood trypomastigotes and then orally administered with 100 mg/kg weight day for 20 days. All of the compounds showed in vitro activity with EC 50 values ranging between 4.6 ± 0.1 μg/mL (14.4 μM) and 36.6 ± 6.1 μg/mL (91 μM). Furthermore, treatment with 3a-f compounds for 20 days resulted in improvement in all of the mice, with a 83–96% decrease in parasitic load at day 90 post-treatment. Treatment with benznidazol (BZ) managed to cure 100% of the mice at the end of treatment. None of the treatments affected the weight of the animals or alanine aminotransferase (ALT), blood urea nitrogen (BUN) and creatinine levels in serum. These results suggest a therapeutic potential of 3a-f compounds as treatment for the infection.

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Risk factors for vertical transmission of Chagas disease: A systematic review and meta-analysis

Cited by 18 publications

References 42 publications

Chagas Disease: Seroprevalence and Associated Factors in Indigenous Communities of the Southern Limit of Argentine Chaco

Chagas Disease: Seroprevalence and Associated Factors in Indigenous Communities of the Southern Limit of Argentine Chaco

Elevated Pediatric Chagas Disease Burden Complicated by Concomitant Intestinal Parasites and Malnutrition in El Salvador

Synthesis and evaluation of the in vitro and in vivo antitrypanosomal activity of 2-styrylquinolines

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