Risk Factors for Premature Hair Graying in Young Turkish Adults

Belli, Aslı Akın; Etgü, Fatma; Gök, Seyran Özbaş; Kara, Bilge; Doğan, Gürsoy

doi:10.1111/pde.12881

Cited by 26 publications

(22 citation statements)

References 16 publications

(30 reference statements)

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“…There are few studies evaluating risk factors associated with PHG in the literature. In these studies, smoking, alcohol consumption, family history of PHG, emotional stress, obesity, and atopy were reported to be associated with PHG . In our study, vegetarian diet preference, atopy history, and family history of PHG were significantly higher in subjects with PHG.…”

Section: Discussionsupporting

confidence: 55%

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Relationship between diet, atopy, family history, and premature hair graying

Acer

Erdoğan

İğrek

et al. 2018

J of Cosmetic Dermatology

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Aim Premature hair graying (PHG) is commonly observed in society, but there are a few studies evaluating risk factors associated with PHG. We aimed to evaluate the socio‐clinical risk factors associated with PHG in this study. Methods A total of 1192 volunteers between 18 and 20 years old were included in this cross‐sectional study. Volunteers were asked to fill in a questionnaire on socio‐clinical risk factors associated with PHG such as smoking, alcohol consumption, diet preference, atopy history, and family history of PHG and Perceived Stress Scale (PSS). Results Three hundred and seventy‐seven (31.6%) of the 1192 volunteers had PHG. Vegetarian diet preference, atopy history, and family history of PHG were significantly higher in subjects with PHG. Mean body mass index (BMI) and PSS scores were higher in subjects with PHG, but was not statistically significant. In the ordinal logistic regression analysis according to severity of PHG, male gender, BMI, alcohol consumption, and history of paternal PHG were significantly higher and onset age of PHG was significantly lower in PHG group. Conclusion Our study is the first study reporting a relationship between PHG and diet. It may be possible to prevent PHG or reduce its severity with some lifestyle changes such as diet preference, having normal weight, and decreasing alcohol consumption.

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Section: Discussionsupporting

confidence: 55%

“…Genetic inheritance of PHG is thought to be autosomal dominant. Some studies reported that family history of PHG was higher in subjects with PHG . In a study including 6392 Korean men who were younger than 30 years old, PHG prevalence was determined as 25.3%.…”

Section: Discussionmentioning

confidence: 97%

Relationship between diet, atopy, family history, and premature hair graying

Acer

Erdoğan

İğrek

et al. 2018

J of Cosmetic Dermatology

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“…Decreased hair tip pigmentation detected in exam students at T2 therefore appears to be a promising surrogate indicator of hampered hair growth in a stressed healthy human. In addition, it may indicate oxidative stress [72] and the onset of premature graying [96]. Some changes in hair measures were however also observed in the comparison group between T1, T2 and T3 and no T2 group differences were found.…”

Section: Discussionmentioning

confidence: 99%

Hair and stress: A pilot study of hair and cytokine balance alteration in healthy young women under major exam stress

et al. 2017

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Mouse models show that experimental stress mimicking prolonged life-stress exposure enhances neurogenic inflammation, induces adaptive immunity cytokine-imbalance characterized by a shift to Type 1 T-helper cell cytokines and increases apoptosis of epithelial cells. This affects hair growth in otherwise healthy animals. In this study, we investigate whether a prolonged naturalistic life-stress exposure affects cytokine balance and hair parameters in healthy humans. 33 (18 exam, 15 comparison) female medical students with comparable sociobiological status were analyzed during a stressful final examination period, at three points in time (T) 12 weeks apart. T1 was before start of the learning period, T2 between the three-day written exam and an oral examination, and T3 after a 12 week rest and recovery from the stress of the examination period. Assessments included: self-reported distress and coping strategies (Perceived Stress Questionnaire [PSQ], Trier Inventory for the Assessment of Chronic Stress [TICS]), COPE), cytokines in supernatants of stimulated peripheral blood mononucleocytes (PBMCs), and trichogram (hair cycle and pigmentation analysis). Comparison between students participating in the final medical exam at T2 and non-exam students, revealed significantly higher stress perception in exam students. Time-wise comparison revealed that stress level, TH1/TH2 cytokine balance and hair parameters changed significantly from T1 to T2 in the exam group, but not the control. However, no group differences were found for cytokine balance or hair parameters at T2. The study concludes that in humans, naturalistic stress, as perceived during participation in a major medical exam, has the potential to shift the immune response to TH1 and transiently hamper hair growth, but these changes stay within a physiological range. Findings are instructive for patients suffering from hair loss in times of high stress. Replication in larger and more diverse sample populations is required, to assess suitability of trichogram analysis as biological outcome for stress studies.

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“…Researchers have uncovered tantalizing clues to the identity of the target molecule that PKA modifies by the addition of a phosphate group (phosphorylation). However, proposals for specific candidate targets, phosphorylation sites [8][9][10] and modulatory mechanisms have been repeatedly called into question by further tests, including some in painstakingly constructed mouse models [11][12][13] . Liu et-al.…”

Section: Whether This Type Of Relationship Extends Beyond Mescs and Hmentioning

confidence: 99%

“…Aside from ageing, there are several factors that bring about premature greying, including dietary deficiencies 5 , disorders such as alopecia areata or vitiligo 6,7 , and stress 8,9 . Zhang et al set out to test the role of stress in the greying process in mice.…”

mentioning

confidence: 99%