Risk Factors for Normal-Tension Glaucoma Among Subgroups of Patients

The risk of newly developed visual impairment in treated normal‐tension glaucoma: 10‐year follow‐up

“…In a study conducted at another tertiary hospital in Korea, the mean age of consecutive patients with NTG (52.1 years) (Park et al. ) was similar to our study.…”

Risk factors for open‐angle glaucoma with normal baseline intraocular pressure in a young population: the Korea National Health and Nutrition Examination Survey

“…21 The mean age of NTG patients in the Low-Pressure Glaucoma Treatment Study was 64.9 years, where the enrolled inclusion criteria were patients 30 years or older. 30 However, in other hospital-based NTG studies of Korean subjects, the mean age of patients was relatively younger (51.8-55.6 years) 18,31,32 and the myopic NTG group was significantly younger than the non-myopic NTG group. 31 Therefore, the relatively younger onset of NTG in Korea might be related to the high prevalence of myopia in a young population.…”

“…As glaucoma is considered to be a neurodegenerative disease and the prevalence increases with age, most of the NTG prevalence and risk factor assessment studies have examined populations aged 40 years or older . It is possible that the population with NTG is not a homogeneous group of patients with glaucoma, and the disease nature and pathogenesis could be different among the age groups, especially in a young population . However, few studies have investigated the risk factors of NTG in a young age group.…”

“…1,2,6,16,17 It is possible that the population with NTG is not a homogeneous group of patients with glaucoma, and the disease nature and pathogenesis could be different among the age groups, especially in a young population. 18 However, few studies have investigated the risk factors of NTG in a young age group.…”

Intraocular pressure reduction with topical medications and progression of normal‐tension glaucoma: a 12‐year mean follow‐up study

“…Normal-tension glaucoma (NTG) is defined as chronic open-angle glaucoma with progressive optic nerve damage and corresponding visual field (VF) defect, despite an untreated intraocular pressure (IOP) that is always measured below 21 mmHg (Tanna & Krupin 2009). Several risk factors have been found to be associated with the prevalence and progression of NTG, such as IOP (CNTGS 1998a,b;Drance et al 2001;Nakagami et al 2006;Aoyama et al 2010), central corneal thickness (Morad et al 1998;Copt et al 1999), disc haemorrhage (Daugeliene et al 1999;Ishida et al 2000;Drance et al 2001;Park et al 2009), disc size (Tuulonen & Airaksinen 1992;Tomita et al 1994;Jonas et al 1995), betazone peripapillary atrophy (Jonas & Xu 1993;Park et al 1996;Daugeliene et al 1999;Kawano et al 2006), myopia (Perkins & Phelps 1982;Drance et al 2001;Suzuki et al 2006;Araie et al 2012) and ocular perfusion pressure (Sung et al 2009(Sung et al , 2011. Of these, IOP is the only modifiable risk factor and has been an important target of NTG treatment.…”