Risk Factors For Mortality In Children Admitted To The ICU With Influenza Infection

Randolph, Adrienne G.; Jouvet, Philippe; Guo, Chao-Yu; Ferdinands, Jill; Yoon, Grace; Flori, Heidi R.; Paden, Matthew L.; Anas, Nicholas; Czaja, Angela S.; Loftis, Laura; Hall, Mark W.; Carroll, Christopher L.; Sullivan, Ryan M.; Helfaer, Mark A.; Thomas, Neal J.; Shay, David K.

doi:10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a3902

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“…Bacterial coinfection may have occurred less commonly in the setting of H1N1 disease than with seasonal influenza, but when identified at initial presentation, it was associated with increased risk of mortality (23,26,27). The clinical course of 2009 H1N1 appeared to diverge from that of seasonal influenza in its more frequent association with concurrent shock in children, a circumstance that predicted increased mortality (26), and in its association with rapidly progressive hypoxia and respiratory failure (28,29).…”

Section: Novel Influenza a In 2009mentioning

confidence: 99%

“…The clinical course of 2009 H1N1 appeared to diverge from that of seasonal influenza in its more frequent association with concurrent shock in children, a circumstance that predicted increased mortality (26), and in its association with rapidly progressive hypoxia and respiratory failure (28,29). Several case series of critically ill children and adults with 2009 H1N1 infection included a cohort of patients who demonstrated a particularly fulminant form of ARDS (28 -32).…”

Section: Novel Influenza a In 2009mentioning

confidence: 99%

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Pediatric respiratory diseases: 2011 update for the Rogersʼ Textbook of Pediatric Intensive Care

Ventre

Wolf²,

Arnold³

2011

Pediatric Critical Care Medicine

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There have been important new developments relevant to the pathogenesis and management of pediatric respiratory diseases. In particular, new insights into the causal pathways of respiratory syncytial virus-induced airways disease can potentially lead to novel therapies. Computed tomography imaging of the injured lung during mechanical ventilation has opened new avenues for future research directed at testing new treatments in acute lung injury subpopulations defined according to lung mechanics. Promising new monitoring techniques may play a supporting role in the conduct of these studies. Finally, evidence from the neonatal literature recently has shown how the course and future consequences of respiratory failure in this population may be modified through more widespread use of noninvasive support.

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Section: Novel Influenza a In 2009mentioning

confidence: 99%

Section: Novel Influenza a In 2009mentioning

confidence: 99%