Risk factors for metabolic syndrome after liver transplantation: A systematic review and meta-analysis

Thoefner, Line B.; Rostved, Andreas Arendtsen; Pommergaard, Hans‐Christian; Rasmussen, Allan

doi:10.1016/j.trre.2017.03.004

Cited by 58 publications

(55 citation statements)

References 56 publications

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“…Disruption of autonomic hepatic innervation has been associated with metabolic pathologies. Patients receiving liver transplants frequently suffer from metabolic derangements as well as immune system failure (Luca et al, 2015; Russo, 2017; Thoefner et al, 2018), likely due to the consequential (partial) disruption of autonomic input to the liver. Moreover, metabolic diseases, such as non-alcoholic fatty liver disease, obesity and type 2 diabetes mellitus, include symptoms of autonomic deregulation, sometimes even manifested prior to disease development (Licht et al, 2013; Wulsin et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Effects of Light-at-Night on the Rat Liver – A Role for the Autonomic Nervous System

et al. 2019

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Exposure to light at night (LAN) has been associated with serious pathologies, including obesity, diabetes and cancer. Recently we showed that 2 h of LAN impaired glucose tolerance in rats. Several studies have suggested that the autonomic nervous system (ANS) plays an important role in communicating these acute effects of LAN to the periphery. Here, we investigated the acute effects of LAN on the liver transcriptome of male Wistar rats. Expression levels of individual genes were not markedly affected by LAN, nevertheless pathway analysis revealed clustered changes in a number of endocrine pathways. Subsequently, we used selective hepatic denervations [sympathetic (Sx), parasympathetic (Px), total (Tx, i.e., Sx plus Px), sham] to investigate the involvement of the ANS in the effects observed. Surgical removal of the sympathetic or parasympathetic hepatic branches of the ANS resulted in many, but small changes in the liver transcriptome, including a pathway involved with circadian clock regulation, but it clearly separated the four denervation groups. On the other hand, analysis of the liver metabolome was not able to separate the denervation groups, and only 6 out of 78 metabolites were significantly up- or downregulated after denervations. Finally, removal of the sympathetic and parasympathetic hepatic nerves combined with LAN exposure clearly modulated the effects of LAN on the liver transcriptome, but left most endocrine pathways unaffected. Conclusion: One-hour light-at-night acutely affects the liver transcriptome. Part of this effect is mediated via the nervous innervation, as a hepatectomy modulated and reduced the effect of LAN on liver transcripts.

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Section: Introductionmentioning

confidence: 99%

Effects of Light-at-Night on the Rat Liver – A Role for the Autonomic Nervous System

et al. 2019

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“…The risk of hypertension caused by immunosuppressive agents can be reduced to a certain extent by adjusting the immunosuppressive regimen, for example, minimizing the immunosuppressive agents (CNIs and glucocorticoids) that may cause hypertension. The risk of hypertension caused by CsA is higher than that caused by TAC[ 46 ]. However, the regimen of MPA represented by MMF combined with CNI reduction regimen can significantly reduce the risk of new-onset hypertension after liver transplantation, and the glucocorticoid-free or early withdrawal regimen can also significantly reduce the incidence of new-onset hypertension after liver transplantation[ 47 - 50 ].…”

Section: Recommendations For the Prophylaxis And Treatment Of Metabolmentioning

confidence: 99%

Expert consensus on management of metabolic disease in Chinese liver transplant recipients

Shen

Li²,

Sun

et al. 2020

WJG

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Metabolic disease, including diabetes mellitus, hypertension, dyslipidemia, obesity, and hyperuricemia, is a common complication after liver transplantation and a risk factor for cardiovascular disease and death. The development of metabolic disease is closely related to the side effects of immunosuppressants. Therefore, optimization of the immunosuppressive regimen is very important for the prevention and treatment of metabolic disease. The Chinese Society of Organ Transplantation has developed an expert consensus on the management of metabolic diseases in Chinese liver transplant recipients based on recent studies. Emphasis is placed on the risk factors of metabolic diseases, the effect of immunosuppressants on metabolic disease, and the prevention and treatment of metabolic diseases.

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“…Notably, both cyclosporine and tacrolimus are associated with hypertension, hyperglycemia, and dyslipidemia, which are the main features of metabolic syndrome, a term that refers to a cluster of cardiovascular risk factors . Indeed, post‐transplant metabolic syndrome (PTMS) has been well documented after abdominal organ transplantation but few reports have discussed PTMS following lung transplantation . PTMS is an appropriate term to consolidate several existing comorbidities including diabetes, hypertension, obesity, and atherogenic dyslipidemia and understand their impact after lung transplantation.…”

Section: Review Of the Literaturementioning

confidence: 99%

Elderly patients with multiple comorbidities: insights from the bedside to the bench and programmatic directions for this new challenge in lung transplantation

Shigemura

Toyoda

2019

Transpl Int

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Summary In aging populations, many patients have multiple diseases characterized by acceleration of the aging process including cardiovascular diseases, metabolic diseases, and chronic kidney disease. Remarkable progress in minimally invasive, interventional therapies, such as percutaneous coronary intervention and transcatheter aortic valve replacement has enabled patients who were previously not transplant candidates because of co‐existing problems to become potentially viable candidates for lung transplantation. Recently, we have observed an outstanding and steady increase in patients older 70 years of age with multiple comorbidities who are referred to our high‐volume center as potential candidates for lung transplantation. However, the impact of diseases characterized by an accelerated aging process and their treatments on transplant outcomes remains unclear. This review aims to highlight these challenges in the current era of lung transplantation, review the prior literature, and discuss future directions with a multidisciplinary view including translational research, transplant medicine, and surgery, as well as from a programmatic and administrative standpoint.

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Risk factors for metabolic syndrome after liver transplantation: A systematic review and meta-analysis

Cited by 58 publications

References 56 publications

Effects of Light-at-Night on the Rat Liver – A Role for the Autonomic Nervous System

Effects of Light-at-Night on the Rat Liver – A Role for the Autonomic Nervous System

Expert consensus on management of metabolic disease in Chinese liver transplant recipients

Elderly patients with multiple comorbidities: insights from the bedside to the bench and programmatic directions for this new challenge in lung transplantation

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