Risk Factors for Lung Cancer in the Province of Lecce: Results from the PROTOS Case–Control Study in Salento (Southern Italy)

Minichilli, Fabrizio; Gorini, Francesca; Filippis, Giovanni De; Bustaffa, Elisa; Raho, Anna Maria; Melcarne, Anna; Quarta, F; Maggiore, Giuseppe; Idolo, Adele; Serio, Francesca; Grassi, Tiziana; Bagordo, Francesco; Castorini, Idelberto Francesco; Imbriani, Giovanni; Bianchi, Fabrizio; Piscitelli, Prisco

doi:10.3390/ijerph19148775

Cited by 3 publications

(2 citation statements)

References 59 publications

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“…In the province of Lecce, southern Italy, exposure to smoking, environmental conditions (use of pesticides in agriculture without PPE), occupational conditions and lifestyle itself need to be further explored as they contribute to the increased risk of cancer, especially due to the identification of a higher incidence of adenocarcinoma, considered a malignant tumor. in men and women from the studied region (MINICHILLI et al, 2022).…”

Section: Driving Themesmentioning

confidence: 93%

Central themes of the relationship between pesticides and cancer: A systematic review of the literature

Aguiar,

Silva,

Silva

et al. 2024

Health and Medicine: Science, Care, and Discoveries

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Objective – to identify central themes in the relationship between pesticides and cancer associated with rural areas, agriculture or agribusiness, through a Systematic Literature Review. Methodology – The research is exploratory, with a quantitative approach for bibliometric analysis and qualitative for the supervision of articles in the final corpus and the discussion of central themes. Results - The analysis of corpus indicators demonstrated that the topic can be considered recent and with a tendency to grow. The coupling bibliographic of the corpus, using the VOSviewer software, showed low quantitative and intensity connections. The thematic map highlights emerging central themes about “breast cancer”, “childhood cancer” and “nervous system”, niche themes such as “DNA damage”, basic themes about “environmental protection” and motors, “health study”, “risk of cancer” and “exposure to pesticides”. Methodological contributions – Identification of themes with reduced bias by centrality and density statistics, which may represent advances in knowledge. Social and environmental contributions – The discussion of the central themes points to the approach of research techniques such as biomarkers and evidence mapping, exposure to pesticides associated with other areas, such as gardens, parks, urban areas, which can cause damage to health beyond the cancer, such as lung and coronary diseases, DNA damage, reporting strategies to reduce these risks through the use of PPE, distance from homes to places that use pesticides, training of farmers. However, these measures seem insufficient, as State regulation allows the use of pesticides within certain limits, generally exceeded, which contributes to damage to health and the environment.

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Section: Driving Themesmentioning

confidence: 93%

Central themes of the relationship between pesticides and cancer: A systematic review of the literature

Aguiar,

Silva,

Silva

et al. 2024

Health and Medicine: Science, Care, and Discoveries

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“…It has been proven that second-hand smoke also increases the risk of developing lung cancer by about 26 % [ 4 ]. Other citable risk factors include positive family history and exposure to asbestos or toxic materials such as polycyclic aromatic hydrocarbons, heavy metals, and radon gas [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

The crosstalk between non-coding RNA polymorphisms and resistance to lung cancer therapies

Mollazadeh,

Abdolahzadeh,

Moghbeli

et al. 2023

Heliyon

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Health effects associated with exposure to secondhand smoke: a Burden of Proof study

Flor,

Anderson,

Ahmad

et al. 2024

Nat Med

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Despite a gradual decline in smoking rates over time, exposure to secondhand smoke (SHS) continues to cause harm to nonsmokers, who are disproportionately children and women living in low- and middle-income countries. We comprehensively reviewed the literature published by July 2022 concerning the adverse impacts of SHS exposure on nine health outcomes. Following, we quantified each exposure–response association accounting for various sources of uncertainty and evaluated the strength of the evidence supporting our analyses using the Burden of Proof Risk Function methodology. We found all nine health outcomes to be associated with SHS exposure. We conservatively estimated that SHS increases the risk of ischemic heart disease, stroke, type 2 diabetes and lung cancer by at least around 8%, 5%, 1% and 1%, respectively, with the evidence supporting these harmful associations rated as weak (two stars). The evidence supporting the harmful associations between SHS and otitis media, asthma, lower respiratory infections, breast cancer and chronic obstructive pulmonary disease was weaker (one star). Despite the weak underlying evidence for these associations, our results reinforce the harmful effects of SHS on health and the need to prioritize advancing efforts to reduce active and passive smoking through a combination of public health policies and education initiatives.

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Risk Factors for Lung Cancer in the Province of Lecce: Results from the PROTOS Case–Control Study in Salento (Southern Italy)

Cited by 3 publications

References 59 publications

Central themes of the relationship between pesticides and cancer: A systematic review of the literature

Central themes of the relationship between pesticides and cancer: A systematic review of the literature

The crosstalk between non-coding RNA polymorphisms and resistance to lung cancer therapies

Health effects associated with exposure to secondhand smoke: a Burden of Proof study

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