Risk Factors for Kidney Cancer in a Japanese Population: Findings from the JACC Study

Washio, Masakazu; Mori, Mitsuru; Sakauchi, Fumio; Watanabe, Yoshiyuki; Ozasa, Kotaro; Hayashi, Kyohei; Miki, Tsuneharu; Nakao, Masahiro; Mikami, Kōichi; Ito, Yoshinori; Wakai, Kenji; Tamakoshi, Akiko

doi:10.2188/jea.15.s203

Cited by 42 publications

(91 citation statements)

References 19 publications

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“…In the JACC study, there is a positive association between hypertension and the development of kidney cancer (age-and sex-adjusted HR=4.27, 95% CI: 2.07 to 8.79) in the population of Japan [8]. In addition, hypertension is a risk factor for kidney cancer death (age-and sex-adjusted HR=1.98, 95% CI: 1.06 to 3.70) in Japan as well [5].…”

Section: Risk Factors Medical Conditionsmentioning

confidence: 99%

“…Hypertension: Hypertension [1,2,17,31] has been reported to be a risk factor for kidney cancer in Western countries [1,2,17,24,26] as well as in East Asian countries (e.g., Japan [5,8], Taiwan [29], Korea [30]). In the JACC study, there is a positive association between hypertension and the development of kidney cancer (age-and sex-adjusted HR=4.27, 95% CI: 2.07 to 8.79) in the population of Japan [8].…”

Section: Risk Factors Medical Conditionsmentioning

confidence: 99%

“…These findings suggest that environmental factors (i.e., non-genetic risk factors) may play an important role in the development of kidney cancer. Therefore, we identified relevant studies [4][5][6][7][8][9][10][11][12][13] in the PubMed database using a combination of the search terms "Japan", "kidney cancer", "renal cell carcinoma" and "risk". In the ICHUSHI database (the Japanese database) we used a combination of the search terms "kidney cancer /renal cell carcinoma", and "risk factor" (the last search update on May 2017).…”

Section: Introductionmentioning

confidence: 99%

“…In this paper, we would like to introduce the result of these studies on the risk factors for kidney cancer in the Japanese population [4][5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Obesity, Diabetes Mellitus, Hypertension and other Risk Factors for Renal Cell Carcinoma in Japan: A Mini-Review

Washio¹,

Mori²

2017

J Clin Exp Nephrol

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Section: Risk Factors Medical Conditionsmentioning

confidence: 99%

Section: Risk Factors Medical Conditionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…In this paper, we would like to introduce the result of these studies on the risk factors for kidney cancer in the Japanese population [4][5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Obesity, Diabetes Mellitus, Hypertension and other Risk Factors for Renal Cell Carcinoma in Japan: A Mini-Review

Washio¹,

Mori²

2017

J Clin Exp Nephrol

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“…Similar findings were shown in a study from Japan. 5 However, apart from smoking, other causative agents remain controversial. …”

Section: Aetiology Of Renal Cancermentioning

confidence: 99%

Modern management of renal cancer

Swallow

Anderson

2008

Trends Urology, Gynecol. Sexual Health

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C ancer of the kidney is a common urological malignancy. A total of 4348 new cases were registered in the UK in 2004 and the incidence is rising. 1 Furthermore, it has considerable morbidity. About 30 per cent of patients present with metastases and a further third of patients develop metastases during their follow-up. Of those who present with metastases, the median survival is about one year. The five-year survival rate in patients with metastatic disease is 0-20 per cent. 2 However, about 70 per cent of patients present with localised or locally advanced disease. These patients are potentially curable by nephrectomy alone (Figure 1). 3 There have been a number of advances in the management of kidney cancer over the past 20 years. A greater understanding of the molecular genetics behind these tumours has led to the use of tailored therapeutic options, either in the adjuvant setting or with those patients presenting with metastases. These include chemotherapy, immunotherapy, tumour vaccines, gene therapy and allogeneic stem-cell transplantation.There have also been advances in surgical options. Nephron-sparing techniques have been developed and minimally invasive options using cryotherapy and radiofrequency ablation have been used successfully on carefully selected patients.Furthermore, several anatomical and histological characteristics, as well as emerging tumour markers, have led to more precise prognostic indicators of disease progression and survival. Aetiology of renal cancerOf the renal cancers, renal cell carcinoma (RCC; an adenocarcinoma) constitutes approximately 85 per cent of all primary malignant tumours. Renal cell carcinoma occurs most commonly in the fifth to sixth decades and has a male to female ratio of 2:1.Renal cell carcinoma is essentially either hereditary or sporadic. Von Hippel-Lindau disease is a familial cancer syndrome in which individuals have a predisposition to develop tumours in multiple organs, including cerebellar haemangioblastoma, retinal angiomata and bilateral clear cell RCC.The aetiology of RCC that occurs de novo is relatively unknown. Occupational exposures, chromosomal aberrations and tumour-suppressor genes have all been implicated. Smoking appears to be the most common risk factor for the development of RCC. In a large prospective study carried out in the USA, 4 hypertension, a high body mass index and smoking appear independently to increase the risk of RCC. Similar findings were shown in a study from Japan. 5 However, apart from smoking, other causative agents remain controversial. Although the prognosis for patients with metastatic kidney cancer is poor, those presenting with localised disease are potentially curable with nephrectomy alone. The authors explain how newer, targeted therapeutic agents show promise of extending survival, and outline recent advances in surgical options and the development of more precise prognostic indicators of disease progression and survival. TOM SWALLOW AND CHRIS ANDERSON

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Occupational class and risk of renal cell cancer

Zaitsu

Cuevas

Trudel‐Fitzgerald

et al. 2018

Health Science Reports

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ObjectivesWe sought to examine the association between occupational class linked to job stress and the risk of renal cell cancer. To identify potential mediators, we additionally examined whether any observed associations persisted even after controlling for the contribution of stress‐related factors (eg, smoking, hypertension, and obesity).MethodsUsing nationwide inpatient records (1984 to 2016) from the Rosai Hospital group in Japan, we identified 3316 cases of renal cell cancer (excluding upper tract urothelial cancer) and 168 418 controls. We classified patients' occupational class (blue‐collar workers, service workers, professionals, and managers) and cross‐classified it by industry type (blue‐collar, service, and white‐collar) based on a standardized national classification. Unconditional logistic regression with multiple imputation was used for the analyses.ResultsA significantly elevated risk of renal cell cancer was found among men in higher occupational class (eg, professionals and managers). The elevated odds in male managers across all industries persisted even after controlling for smoking and alcohol consumption, with the association being more pronounced in blue‐collar industries (OR, 1.61; 95% CI, 1.34‐1.93). The association appeared to be mainly mediated by hypertension.ConclusionOccupational class is associated with the risk of renal cell cancer in men, particularly through modifiable risk factors.

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Risk Factors for Kidney Cancer in a Japanese Population: Findings from the JACC Study

Cited by 42 publications

References 19 publications

Obesity, Diabetes Mellitus, Hypertension and other Risk Factors for Renal Cell Carcinoma in Japan: A Mini-Review

Obesity, Diabetes Mellitus, Hypertension and other Risk Factors for Renal Cell Carcinoma in Japan: A Mini-Review

Modern management of renal cancer

Occupational class and risk of renal cell cancer

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