Risk factors for hidradenitis suppurativa: a pilot study

Schmitt, Juliano Vilaverde; Bombonatto, Giovana; Martin, Manoela Mário; Miot, Hélio Amante

doi:10.1590/s0365-05962012000600024

Cited by 23 publications

(22 citation statements)

References 8 publications

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“…Patients with HS were younger, and more likely to be black, uninsured and admitted during the autumn and summer months. We observed higher rates of HS in female inpatients, which appears to be consistent with previous findings that women are more likely to have HS, especially during puberty when the secretory activity of apocrine glands is increased . A previous retrospective cohort study found the incidence of HS to be higher in female patients, particularly younger female patients and in African Americans .…”

Section: Discussionsupporting

confidence: 91%

Associations of cutaneous and extracutaneous infections with hidradenitis suppurativa in U.S. children and adults

et al. 2019

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Summary Background Hidradenitis suppurativa (HS) is associated with bacterial colonization, skin‐barrier disruption, immune dysregulation and treatments that can increase infection risk. Objectives To determine whether HS is associated with cutaneous and extracutaneous infections and related outcomes. Methods Data from the 2002–2012 National Inpatient Sample were analysed, including a 20% sample of U.S. hospitalizations (n = 87 053 155). Results The prevalence (with 95% confidence interval) of infections was higher in adults (34·0%, 33·2–34·7% vs. 23·4%, 23·2–23·6%) and children (31·8%, 28·7–34·9% vs. 12·6% (12·1–13·1%) with vs. without HS. Inpatients with HS had higher prevalences of infections overall (excluding cellulitis and erysipelas) than those with psoriasis, but lower than those with atopic dermatitis. In multivariable logistic regression models adjusting for sociodemographics, HS was associated with 18 of 45 infections examined (adults: 16 of 45; children: six of 45), including acute infections (herpes simplex virus, herpes zoster, necrotizing fasciitis, septicaemia, bone infection, Clostridium difficile, methicillin‐sensitive and methicillin‐resistant Staphylococcus aureus, Streptococcus, Pseudomonas, mycobacterial, fungal, viral), chronic infections (HIV, hepatitis B) and antibiotic‐resistant infections. HS alone was associated with increased infections. Patients with comorbid cancer; HIV; cardiometabolic, autoimmune or mental health diagnoses or acne had even higher odds of infections. Inpatients with HS with vs. without serious infection had increased inpatient mortality (0·71% vs. 0·16%), mean length of stay (7·3 vs. 4·8 days) and cost of care (US$13 578 vs. $9242), with a mean annual excess 41 050 days and $71 622 339 cost of hospitalization. Conclusions Adults and children with HS had increased acute and chronic, cutaneous, extracutaneous and systemic infections, which were associated with increased mortality and cost. What's already known about this topic? Little is known about the risk of infection in patients with hidradenitis suppurativa (HS). What does this study add? Adults and children with HS had increased cutaneous, extracutaneous and systemic infections, at even higher rates than in patients with psoriasis and atopic dermatitis. These infections were associated with increased inpatient mortality and cost. Respond to this article

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Section: Discussionsupporting

confidence: 91%

Associations of cutaneous and extracutaneous infections with hidradenitis suppurativa in U.S. children and adults

et al. 2019

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“…Brazilian HS subjects were mainly adults between third and fourth decades, which corroborate the results of two previous hospital‐based Brazilian studies . The prevalence of the disease increases after puberty, according to apocrine glands maturity.…”

Section: Prevalence Of Hidradenitis Suppurativa According To Dermatolsupporting

confidence: 88%

“…Hidradenitis suppurativa (HS) is a chronic and relapsing follicular autoinflammatory disorder that inflicts major impact in quality of life . Population prevalence studies of HS are scarce, especially in Latin America …”

Section: Prevalence Of Hidradenitis Suppurativa According To Dermatolmentioning

confidence: 99%

Prevalence of hidradenitis suppurativa in Brazil: a population survey

2018

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“…After evaluation of the abstract and when necessary, the full text, nine studies were found to be eligible for inclusion in this systematic review (Fig. ) . General characteristics of the eligible studies included are presented in Table .…”

Section: Resultsmentioning

confidence: 99%

Cardiovascular disease risk factors in patients with hidradenitis suppurativa: a systematic review and meta-analysis of observational studies

et al. 2015

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Hidradenitis suppurativa (HS) is a chronic, inflammatory, debilitating skin disease. The aim of the study was to systematically review the literature and critically answer the question: In patients with HS, do cardiovascular risk factors appear at a significantly higher rate compared with controls? The main search was conducted in Medline, Embase and the Cochrane Central Register. Studies eligible for inclusion were of case-control, cross-sectional and cohort design, and included comparison of any cardiovascular risk factor(s) in patients with HS with those of control groups. An I(2) value > 50% was considered to show substantial heterogeneity. In this case, DerSimonian and Laird random-effect models were considered to compute pooled odds ratios (OR). Otherwise, a fixed-effects model was suitable. Nine studies, with 6174 patients with HS and 24 993 controls, were included. Significant association of HS with obesity [OR 3·45, 95% confidence interval (CI) 2·20-5·38, P < 0·001], central obesity (OR 2·97, 95% CI 1·41-6·25, P = 0·004), active smoking (OR 4·34, 95% CI 2·48-7·60, P < 0·001), history of smoking (OR 6·34, 95% CI 2·41-16·68, P < 0·001), hypertriglyceridemia (OR 1·67, 95% CI 1·14-2·47, P = 0·009), low high-density lipoprotein (HDL) (OR 2·48, 95% CI 1·49-4·16, P < 0·001), diabetes (OR 2·85, 95% CI 1·34-6·08, P = 0·007) and metabolic syndrome (OR 2·22, 95% CI 1·62-3·06, P < 0·001) was detected. Associations were significant both in population and hospital patients with HS, with hospital HS groups having uniformly higher ORs than the population HS groups. Causality could not be assessed. Heterogeneity was substantial in all analyses. This systematic review indicated that cardiovascular risk factors appear at a significantly higher rate in patients with HS compared with controls. The need for screening of patients with HS for modifiable cardiovascular risks is emphasized.

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Risk factors for hidradenitis suppurativa: a pilot study

Cited by 23 publications

References 8 publications

Associations of cutaneous and extracutaneous infections with hidradenitis suppurativa in U.S. children and adults

Associations of cutaneous and extracutaneous infections with hidradenitis suppurativa in U.S. children and adults

Prevalence of hidradenitis suppurativa in Brazil: a population survey

Cardiovascular disease risk factors in patients with hidradenitis suppurativa: a systematic review and meta-analysis of observational studies

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