Risk Factors for Hemorrhagic and Cardioembolic Complications of Intracerebral Hemorrhage Associated with Anticoagulants

Osawa, Satoshi; Shimizu, Tatsuya; Kano, Tadashige; Shintoku, Ryosuke; Fujimaki, Hiroya; Asakura, Ken

doi:10.1016/j.jstrokecerebrovasdis.2018.09.054

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…In particular, recent reports have shown that inflammation is directly related to AF which maybe is a direct result of inflammation 39 . It has also been reported that inflammation may be important in the occurrence factor of CE 40 . These views provide a good explanation for our findings.…”

Section: Discussionmentioning

confidence: 94%

Serum beta2-microglobulin levels are highly associated with the risk of acute ischemic stroke

Qun

Wang

et al. 2019

Sci Rep

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Inflammation is considered an important mechanism of cell death or survival after ischemic stroke. As an important marker of inflammation, the role of β2-microglobulin (β2M) in acute ischemic stroke is unclear. We investigated the relationship between serum β2M and the risk of acute ischemic stroke (AIS). Patients with AIS (202 cases), intracerebral hemorrhage (ICH, 41 cases), and healthy controls (253 cases) were recruited. Clinical and biochemical characteristics were collected. We used three binary logistic regression models to evaluate the correlation of β2M with the risk of AIS. Furthermore, we investigated the relationship between serum β2M and the National Institute of Health Stroke Scale (NIHSS) score, the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) subtypes, and the Essen Stroke Risk Score (ESRS) in patients with AIS. Our results showed that serum β2M levels in patients with AIS were much higher than those in patients with ICH and in the control subjects. Individuals with higher levels of β2M had higher odds of AIS. Moreover, serum β2M levels were significantly and positively correlated with ESRS. In addition, the levels of β2M were varied with different subgroups of AIS (TOAST classification). Serum β2M is highly associated with the risk of AIS.

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Section: Discussionmentioning

confidence: 94%

Serum beta2-microglobulin levels are highly associated with the risk of acute ischemic stroke

Qun

Wang

et al. 2019

Sci Rep

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“…Warfarin is one of the most widely used drugs in the prevention and treatment of thromboembolic events (1). Hemorrhagic events are common complications in patients receiving this continuous oral anticoagulation therapy and are seen in approximately 10% of cases (2). Major bleeding, which may be in the form of minor or major bleeding, is frequently in the form of intracranial or retroperitoneal bleeding (2,3).…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Pelvic Hemorrhage and Rectus Sheath Hematoma due to Anticoagulant Overdose: A Case Report

Özdemir¹

2020

abantmedj

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Hemorajik olaylar, bu sürekli oral antikoagülasyon tedavisi alan hastalarda sık görülen komplikasyonlardır. 75 yaşında bayan hasta acil servise karın ağrısı şikâyeti ile başvurdu. Hastanın koroner bypass ameliyatı öyküsü mevcuttu ve warfarin kullanıyordu. Fizik muayenesinde karnının alt kadranda hassasiyeti vardı. INR değeri 9.11 idi. Bilgisayarlı tomografide pelvik hematom ve rektus kılıf hematomu izlendi. Hasta konservatif olarak taze donmuş plazma ile tedavi edildi. Başvurmasından 2 gün sonra komplikasyon gelişmeksizin taburcu edildi.Özellikle yaşlı hastalar antikoagülanların yan etkileri konusunda bilgilendirilmelidir.

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“…According to the marked increase in the elderly population in Japan, an increasing number of patients were administered with anticoagulant agents, either for secondary prevention of ischemic stroke or primary prevention in patients with nonvalvular arterial fibrillation. Patients with hemorrhagic stroke or hemorrhagic conversion of ischemic stroke during anticoagulant therapy were reported to have poorer clinical outcomes owing to the difficulty in acute neurosurgical management, but the risk assessment for hemorrhagic events associated with anticoagulants in the central nervous system is not easy (1) .…”

mentioning

confidence: 99%

Recent Management Option for Hemorrhagic Stroke during Direct Oral Anticoagulant Therapy

2023

JMA J

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Risk Factors for Hemorrhagic and Cardioembolic Complications of Intracerebral Hemorrhage Associated with Anticoagulants

Cited by 4 publications

References 16 publications

Serum beta2-microglobulin levels are highly associated with the risk of acute ischemic stroke

Serum beta2-microglobulin levels are highly associated with the risk of acute ischemic stroke

Spontaneous Pelvic Hemorrhage and Rectus Sheath Hematoma due to Anticoagulant Overdose: A Case Report

Recent Management Option for Hemorrhagic Stroke during Direct Oral Anticoagulant Therapy

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