Risk factors for development of primary bladder squamous cell carcinoma

Manley, Kate; Hubbard, Rachel; Swallow, DM; Finch, William; Wood, Sarah; Biers, Suzanne

doi:10.1308/rcsann.2016.0343

Cited by 17 publications

(12 citation statements)

References 35 publications

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“…While there is a wellestablished causative relationship between infections with the urogenital parasite Schistosoma haematobium and bladder cancer, [5] [6] the association between bacterial urinary tract infections and bladder cancer is less clear. Data from large epidemiological studies suggest that an association may be present, [7] [8] with other work suggesting that recurrent UTIs may be a particular risk factor for squamous cell carcinoma of the bladder [11]. However, other work has not found such an relationship between UTI and bladder cancer.…”

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confidence: 86%

Profiling of urine bacterial DNA to identify an “oncobiome” in a mouse model of bladder cancer

Banskota

et al. 2018

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Introduction: Recurrent urinary tract infections have been linked to increased risk of bladder cancer, suggesting a potential role of the urinary microbiome in bladder cancer pathogenesis.Objective: Compare the urinary microbiomes in mice with and without bladder. Methods:Longitudinal study of mice exposed to a dilute bladder-specific carcinogen (0.05% nbutyl-n-(4-hydroxybutyl) nitrosamine, BBN mice, n=10), and control mice (n=10). Urine was sampled monthly from individual mice for 4 months. Microbial DNA was extracted from the urine, and the V4 region of the 16S rRNA gene sequenced. Animals were sacrificed and their bladders harvested for histopathology. Bladder sections were graded by a blinded pathologist. The composition and diversity of the urinary microbiome were compared between the BBN and control mice. Metabolic pathway analysis was completed using PICRUST.Results: Bladder histology in the BBN group showed normal tissue with inflammation (BBNnormal, n=5), precancerous pathologies, (BBN-precancerous, n=3), and invasive cancer (BBNcancer, n=2). Alpha diversity did not differ between the mice exposed to BBN and the control mice at any timepoint. There were no differences in the urinary microbiomes between the BBN and control mice at baseline. At month 4, mice exposed to BBN had higher proportion of both Gardnerella and Bifidobacterium compared to control mice. There were no differences in proportions of specific bacteria between either the BBN-precancer or BBN-cancer and controls at month 4. However, the BBN-normal mice had higher proportions of Gardnerella, Haemophilus, Bifidobacterium, and Ureaplasma Actinobaculum, and lower proportions of Actinomyces, compared to control mice at month 4. Functional pathway analysis demonstrated increases in genes related to purine metabolism, phosphotransferase systems, peptidases, protein folding, and bacterial toxins in the BBN-mice compared to control mice at month 4.Conclusion: Mice exposed to 4 months of BBN, a bladder-specific carcinogen, have distinct urine microbial profiles compared to control mice.

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confidence: 86%

Profiling of urine bacterial DNA to identify an “oncobiome” in a mouse model of bladder cancer

Banskota

et al. 2018

Preprint

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“…To our knowledge, only three cases of squamous cell bladder tumors have been reported in pregnant women (Table 1 ). Risk factors for squamous cell bladder tumors are a history of catheter use (clean intermittent self-catheterization or an indwelling catheter), smoking and recurrent urinary tract infections [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Bladder squamous cell carcinoma in a pregnant woman: case report and review of the literature

et al. 2021

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Background Bladder tumors in pregnancy are extremely rare. No more than 50 cases have been published to date, including all histologic variants, and only three cases of bladder squamous cell carcinoma have been described. Case presentation We present a clinical case of a 31-year-old woman with bladder squamous cell carcinoma in the second trimester of pregnancy. After a C-section at 30 weeks, we performed radical cystectomy with extended bilateral lymphadenectomy, hysterectomy and right oophorectomy. The Studer neobladder technique was performed for urinary tract reconstruction. Definitive pathology showed invasive bladder squamous cell carcinoma, Grade 2, with microscopic infiltration of the perivesical fat, negative margins, and 3/28 lymph nodes with carcinoma (pT3aN2M0). The patient underwent 18 months of surveillance after radical cystectomy, without recurrence by PET-CT. Conclusions Bladder cancer in pregnant women is extremely rare but must be considered in those with recurrent gross hematuria and/or recurrent urinary tract infection. To our knowledge, this case involves the longest recurrence-free survival of a pregnant woman with squamous cell bladder cancer published thus far.

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“…In western countries the NB-SCC subtype is more common, which accounts for 2-5% of bladder neoplasms [1][2][3]. Important risk factors for NB-SCC are smoking, recurrent urinary infections, and the use of chronic indwelling urinary catheters causing reactive chronic inflammatory and proliferative pathologic changes of the bladder [1,4,5]. The incidence of NB-SCC in paraplegic patients is therefore 16-28 times higher.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, early discovery with surveillance cystoscopy and urine cytology might be considered in high-risk groups with neurogenic bladder dysfunction, like spina bifida. However, screening on NB-SCC is still under debate because the ideal starting point and frequency are unknown [1,5,15,16]. Conflicting interests: All Authors declare that there is no conflict of interest.…”

Section: Discussionmentioning

confidence: 99%

A paraplegic patient with fever and leucocytosis: not always what it seems

et al. 2019

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A 54-year-old obese woman with a history of spina bifida was admitted to the hospital with malaise and fever accompanied by leucocytosis, thrombocytosis, and hypercalcaemia. As treatment for neurogenic bladder dysfunction she had a suprapubic catheter. Diagnostic workup for osteomyelitis revealed an unknown mass originating from the urinary bladder on MRI of the pelvis. Further diagnostic analyses showed that the mass was a squamous-cell carcinoma (SCC) with laboratory abnormalities as paraneoplastic phenomena mediated by PTH-related peptide and cytokines released by the SCC. Despite radiotherapy the patient died within two months after initial diagnosis.Squamous-cell carcinoma of the bladder is rare in western countries. In unresectable or metastatic disease survival rates are low due to low responsiveness to standard chemotherapy. Concurrent chemoradiotherapy might be an alternative in unresectable or locally advanced disease; however, evidence to support this is lacking. The poor survival in these patients raises the question of whether high-risk groups for SCC of the bladder, like paraplegic patients or patient with neurogenic bladder dysfunction, should receive screening even though the ideal starting point and frequency are still unknown.

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Risk factors for development of primary bladder squamous cell carcinoma

Cited by 17 publications

References 35 publications

Profiling of urine bacterial DNA to identify an “oncobiome” in a mouse model of bladder cancer

Profiling of urine bacterial DNA to identify an “oncobiome” in a mouse model of bladder cancer

Bladder squamous cell carcinoma in a pregnant woman: case report and review of the literature

A paraplegic patient with fever and leucocytosis: not always what it seems

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