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Cited by 155 publications
(119 citation statements)
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“…It is known that hypertension accelerates the decline in cerebral perfusion [44,45]. Altered regional cerebral bloodflow in hypertensive subjects in the middle/posterior watershed areas has been found [45].…”
Section: Discussionmentioning
confidence: 99%
“…It is known that hypertension accelerates the decline in cerebral perfusion [44,45]. Altered regional cerebral bloodflow in hypertensive subjects in the middle/posterior watershed areas has been found [45].…”
Section: Discussionmentioning
confidence: 99%
“…Vascular NO production could be a therapeutic target during CBH, a hemodynamic abnormality well known to exist during human MCI and continuing later in the development of progressive AD (de la Torre, 2002b;de la Torre et al, 1997de la Torre et al, , 2004Johnson and Albert, 2000;Kalaria, 2000;Meyer et al, 2000).…”
Section: Discussionmentioning
confidence: 99%
“…This finding is relevant in understanding the physiopathology of AD because there is now considerable evidence that this dementia may develop from cerebrovascular events that lead to AD neurodegeneration (Breteler, 2000;de la Torre, 2000de la Torre, , 2002ade la Torre, , b, 2004de la Torre and Mussivand, 1993;Kivipelto et al, 2001;Meyer et al, 2000;Roher et al, 2003;Skoog, 1999;Vermeer et al, 2003;Iadecola, 2004).…”
Section: Introductionmentioning
confidence: 94%
“…There is accumulating evidence that BP reduction can reduce the incidence of dementia or cognitive decline in elderly hypertensive patients, 22,23,24 possibly by improving cerebral blood flow. 25 Currently, the weight of evidence suggests that antihypertensive therapy can improve cerebral perfusion, improve carotid artery distensibility, and prevent some of the adverse functional consequences of both large and small vessel disease of the brain. Beat-to beat changes in pulsatile diameter of the carotid artery (top row) and pulsatile carotid distensibility (bottom row) at baseline and after 6 months of observation in normotensive and controlled hypertensive groups, and at baseline and after 6 months of antihypertensive therapy in the uncontrolledcontrolled hypertensive group.…”
Section: Perspectivesmentioning
confidence: 99%