Risk factors for bacterial infections in HIV/hepatitis C virus-coinfected patients treated with interferon plus ribavirin

Bani‐Sadr, Firouzé; Goderel, Isabelle; Lapidus, Nathanaël; Driss, Henda; Simon, Anne; Rosenthal, Éric; Morand, Patrice; Lunel‐Fabiani, Françoise; Pol, Stanislas; Cacoub, Patrice; Perronne, Christian; Carrat, Fabrice

doi:10.1097/qad.0b013e328305bd8d

Cited by 6 publications

(3 citation statements)

References 8 publications

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“…Bani-Sadr et al [19] observed 18 bacterial infections in 17 of 383 patients with HIV/HCV coinfections who received at least one dose of interferon plus ribavirin. According to univariate analysis, the risk factors for these infections included a longer history of HCV infection and low hemoglobin concentrations, prothrombin levels, and leukocyte, neutrophil, and platelet counts.…”

Section: Discussionmentioning

confidence: 99%

“…According to univariate analysis, the risk factors for these infections included a longer history of HCV infection and low hemoglobin concentrations, prothrombin levels, and leukocyte, neutrophil, and platelet counts. The HCV infection duration and the prothrombin level remained significantly associated with the risk of bacterial infection according to multivariate analysis [19]. …”

Section: Discussionmentioning

confidence: 99%

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Cryptococcal meningitis in a patient with chronic hepatitis C treated with pegylated-interferon and ribavirin

Lee

Kim

et al. 2014

Korean J Intern Med

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Various adverse events have been reported during combination therapy with pegylated (PEG)-interferon-α and ribavirin, although opportunistic infections, especially cryptococcal meningitis, are very rare. A 61-year-old woman complained of headaches and a fever during treatment of a chronic hepatitis C virus (HCV) infection. She had been treated for 7 months. Her headaches were refractory to analgesics, and she developed subtle nuchal rigidity. The cerebral spinal fluid (CSF) revealed a white blood cell count of 205/mm3, 51 mg/dL protein, 35 mg/dL glucose, and negative Cryptococcus antigen. The CSF culture resulted in no growth. Five days later, the CSF was positive for Cryptococcus antigen. We administered amphotericin B and flucytosine, followed by fluconazole. Approximately 2 months later, she was discharged. For the first time, we report a case of cryptococcal meningitis during the treatment of chronic HCV with PEG-interferon-α and ribavirin.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cryptococcal meningitis in a patient with chronic hepatitis C treated with pegylated-interferon and ribavirin

Lee

Kim

et al. 2014

Korean J Intern Med

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show abstract

“…HCV therapy is also unlikely to play a deleterious role, despite side effects such as lymphopenia, neutropenia, or anemia, because of the low percentage of HCV-HIV-coinfected patients who are treated, the limited duration of treatment, the reversibility of hematological side effects, and the lack of significant related clinical consequence in therapeutic trials [31]. On the contrary, HCV therapy might, in fact, decrease the risk of AIDS-defining events, in particular through prevention of evolution to cirrhosis.…”

mentioning

confidence: 99%