Risk factors, follow-up, and treatment of urethral recurrence following radical cystectomy and urinary diversion for bladder cancer: a meta-analysis of 9498 patients

Li, Xinyuan; Wang, Wuwan; Zhu, Gongmin; He, Weiyang; Gou, Xin

doi:10.18632/oncotarget.23451

Cited by 23 publications

(18 citation statements)

References 45 publications

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“…The procedure involves removal of the entire bladder, lymph nodes, part of the urethra, and nearby organs that may contain cancer cells. Still, patients after RC remain at risk of BC recurrence with remaining urethra as a common recurrence site 8 .…”

Section: Introductionmentioning

confidence: 99%

The interplay between adipose-derived stem cells and bladder cancer cells

Maj

Kokocha

Bajek

et al. 2018

Sci Rep

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Tissue engineering approaches offer alternative strategies for urinary diversion after radical cystectomy. Possible triggering of cancer recurrence remains, however, a significant concern in the application of stem-cell based therapies for oncological patients. Soluble mediators secreted by stem cells induce tissue remodelling effects, but may also promote cancer cells growth and metastasis. We observed a substantial increase in the concentration of IL-6 and IL-8 in the secretome of adipose-derived stem cells (ASCs) co-cultured with bladder cancer cells. Concentrations of GM-CSF, MCP-1 and RANTES were also elevated. Bioactive molecules produced by ASCs increased the viability of 5637 and HT-1376 cells by respectively 15.4% and 10.4% (p < 0.0001). A trend in reduction of adhesion to ECM components was also noted, even though no differences in β-catenin expression were detected. When HT-1376 cells were co-cultured with ASCs their migration and invasion increased by 24.5% (p < 0.0002) and 18.2% (p < 0.002). Expression of p-ERK1/2 increased in 5637 cells (2.2-fold; p < 0.001) and p-AKT in HB-CLS-1 cells (2.0-fold; p < 0.001). Our results confirm that ASCs crosstalk with bladder cancer cells in vitro what influences their proliferation and invasive properties. Since ASCs tropism to tumour microenvironment is well documented their application towards post-oncologic reconstruction should be approached with caution.

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Section: Introductionmentioning

confidence: 99%

The interplay between adipose-derived stem cells and bladder cancer cells

Maj

Kokocha

Bajek

et al. 2018

Sci Rep

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“…In keeping with this finding, in a large-scale study involving 6,169 patients, HR of CIS for UR was 0.97 (p=0.88). 4 However, in a large meta-analysis of 9,498 patients, 21 BC patients with CIS showed a higher probability of developing UR than patients without CIS (RR = 3.09; 95% CI: [1.48, 6.47]), which may be attributed to the inclusion of female patients in this meta-analysis.…”

Section: Discussionmentioning

confidence: 81%

“…20 Conversely, another study reported higher UR rate in low-stage than high-stage tumors. 21 On the other hand, Kang Su Cho demonstrated that tumor stage is not an independent risk factor of UR. 18 These discrepancies may be ascribed to that there are no pT1 stage patients and only male patient included in our study.…”

Section: Dovepressmentioning

confidence: 99%

“…According to previous reports, multifocality was a risk factor of UR. 23,24 A study by Li et al 21 disclosed significant differences between solitary and multifocal BC of UR (RR=2.93; 95% CI: [1.93,4.44]), the mechanism possibly is due to polycentric tumor growth. On the contrary, Stein and co-workers observed that the presence of tumor multifocality tended not to be associated with increased risk of UR (P = 0.06), however this finding was borderline statistically significant.…”

Section: Dovepressmentioning

confidence: 99%

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<p>Development and Validation of a Model for Predicting Urethral Recurrence in Male Patients with Muscular Invasive Bladder Cancer After Radical Cystectomy Combined with Urinary Diversion</p>

Liu¹,

Zhang²,

Wu³

et al. 2020

CMAR

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Purpose: Radical cystectomy (RC) is the primary treatment strategy for patients with muscular invasive bladder cancer (MIBC). However, the prognosis is poor and tumor recurrence is not rare, in particular, urethral recurrence (UR) in male patients who underwent RC combined with urinary diversion. Here, we have developed and validated a model for predicting UR in these patients. Patients and Methods: The development cohort comprised 310 patients who underwent RC combined with urinary diversion at our center between 1 January 2007 and 31 December 2015. Clinicopathologic data of patients were comprehensively recorded. Multivariate Cox proportional hazard regression was used for building a predictive model with regression coefficients and backward stepwise selection applied by utilizing the likelihood ratio test with Akaike's information criterion as the stopping rule. An independent cohort consisting of 131 consecutive patients treated from 1 January 2016 to 31 December 2017 was used for validation. The performance of this predictive model was assessed with respect to discrimination, calibration, and clinical usefulness. Results: The predictors of this model included body mass index, history of transurethral resection of bladder tumor, tumor grade, tumor stage, and concomitant carcinoma in situ. In the validation cohort, the model showed good discrimination with a concordance index of 0.777 (95% CI, 0.618 to 0.937) and calibration. Decision curve analysis also demonstrated the clinical utility of the model. Conclusion: The predictive model facilitated postoperative individualized prediction of UR in male patients with MIBC after RC combined with urinary diversion and it may therefore serve to improve follow-up strategies.

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“…Radical cystectomy with urinary diversion is the method of choice for the treatment of muscle- invasive bladder cancer. [ 1 ] In these cases, urinary diversion is achieved by the reconstruction of an orthotopic neobladder or an ileal conduit. [ 2 ] Transitional cell carcinoma, the most common pathological type of bladder carcinoma, is defined as a pan-urothelial disease characterized by recurrent and multifocal metachronous tumors of urinary organs.…”

Section: Introductionmentioning

confidence: 99%

Urethral Recurrence of Urothelial Carcinoma of the Bladder Following Radical Cystectomy: An Unusual Imaging Pattern

Özdemir

Kavak

Eren

2020

JCIS

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Residual urethra is a common site of recurrence in patients undergoing radical cystectomy with urinary diversion for bladder cancer. Urethral recurrence (UR) clinically manifests as a penile mass or a bloody or purulent penile discharge at a median of 13 months after surgery. And on imaging studies, it characteristically appears as a focal intraluminal mass, urethral wall thickening, or an infiltrating mass arising from the urethra. We, herein, present an unusual case of UR manifesting as a large cyst in the penile root 4 years after radical cystectomy with urinary diversion for muscle-invasive bladder cancer. Further, a complex cystic mass developed in the same location 2 years after the excision of the cystic UR. This case shows that the imaging spectrum of UR after radical cystectomy may be wider and may include cystic and complex patterns.

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Risk factors, follow-up, and treatment of urethral recurrence following radical cystectomy and urinary diversion for bladder cancer: a meta-analysis of 9498 patients

Cited by 23 publications

References 45 publications

The interplay between adipose-derived stem cells and bladder cancer cells

The interplay between adipose-derived stem cells and bladder cancer cells

<p>Development and Validation of a Model for Predicting Urethral Recurrence in Male Patients with Muscular Invasive Bladder Cancer After Radical Cystectomy Combined with Urinary Diversion</p>

Urethral Recurrence of Urothelial Carcinoma of the Bladder Following Radical Cystectomy: An Unusual Imaging Pattern

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