Risk factors and pathogenic bacteria of central venous catheter-associated bloodstream infection in patients with emergency hemorrhagic shock: a single-center retrospective Study from 2016 to 2022 in a Teaching Hospital in China

Abstract

Objective To investigate and analyze the risk factors and pathogenic bacteria of central venous catheter-associated bloodstream infection in patients with emergency hemorrhagic shock. Methods According to the inclusion criteria, 249 patients with hemorrhagic shock and central venous catheterization admitted to the emergency department of Shanghai General Hospital from June 2016 to June 2022 were retrospectively analyzed, and divided into the infection group (54 cases) and the non-infection group (195 cases) according to whether catheter-related bloodstream infection occurred.Multivariate Logistic regression was used to analyze the relationship between central venous catheter-related bloodstream infection and various influencing factors. The etiological and drug susceptibility test data of peripheral venous blood culture, puncture site samples and catheter tip samples from patients with central venous catheter-associated bloodstream infection were statistically analyzed. Results There were significant differences in age, catheterization location, ultrasound-guided puncture, APACHE ⅱ score, catheter indwelling time and application of broad-spectrum antibiotics between the infected group and the non-infected group (P < 0.05). Staphylococcus epidermis accounted for 44.6%, Escherichia coli 23.2%, and fungi 12.5% in 54 infected patients. The lowest resistance rate of Gram-positive cocci was to vancomycin(3.4%),followed by tetracycline 34.5%,and the highest resistance rate was to amoxicillin 100.0%. Conclusion The risk factors of central venous catheter-related bloodstream infection in patients with emergency hemorrhagic shock include advanced age,femoral vein catheterization,non-ultrasound-guided puncture,high APACHE ⅱ score,catheter retention time,and application of broad-spectrum antibiotics.Staphylococcus epidermis the common pathogen of central venous catheterization related infection in emergency hemorrhagic shock patients.