Rising Incidence of Inflammatory Bowel Disease Among Children: A 12‐year Study

Malaty, Hoda M.; Fan, Xiaolin; Opekun, Antone R.; Thibodeaux, Carolyn; Ferry, George D.

doi:10.1097/mpg.0b013e3181b99baa

Cited by 191 publications

(76 citation statements)

References 40 publications

(63 reference statements)

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“…[35] The 2 U.S. studies addressing temporal trends included in this review were limited to 2 different time periods and geographic regions. They also identified contradictory results: a 118% increase in incidence in a single institution in Texas[36] and an 11% decrease in a statewide population study in Minnesota. [37] A national study of U.S. private payer data found a less than 10% increase in prevalence from 2004 to 2009.…”

Section: Discussionmentioning

confidence: 99%

Increasing Hospitalizations in Inflammatory Bowel Disease Among Children in the United States, 1988–2011

Sandberg

Davis

Adler

2014

Inflammatory Bowel Diseases

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Background Our objective was to characterize national trends in inflammatory bowel disease (IBD)-related hospitalizations for children. We hypothesized that over time, improvements in care would be associated with a decrease in hospitalization rates, similar to what has been observed in Canadian children with IBD. Methods Retrospective, serial, cross-sectional analysis of annual, nationally representative samples of children with IBD. Results Overall, discharges for all children irrespective of diagnosis decreased from 1988 to 2011 (P for trend <0.001). In contrast, discharges for children with IBD rose over the same time period from 6.1 (95% confidence interval [CI], 4.0–8.2) to 8.2 (95% CI, 5.5–10.9) per 100,000 individuals per year (P for trend <0.001). More of this rise occurred in hospitalizations that did not have IBD-related endoscopy or surgery performed (P for trend <0.001). Although mean length of stay decreased over the study period (P for trend <0.001), total hospital days increased over the latter half of the study with a significant increase over the entire study period (P for trend <0.001). Conclusions Contrary to clinically informed hypotheses, nationally representative rates of hospitalization for pediatric patients with IBD have increased since the mid-1990s. This directly contrasts with stable rates over the preceding years. Most of the expansion in hospital care seems to be related to hospitalizations that do not include procedures. Several lines of future research may greatly facilitate a better understanding of the epidemiologic, therapeutic, and health care resource issues at play.

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Section: Discussionmentioning

confidence: 99%

Increasing Hospitalizations in Inflammatory Bowel Disease Among Children in the United States, 1988–2011

Sandberg

Davis

Adler

2014

Inflammatory Bowel Diseases

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“…11, 12, 14, 15 Rates of IBD for migrants to the US have not been reported, although there is evidence from Southeast Asian migrants to the United Kingdom that migrant populations rapidly assume the incidence rate of the underlying population or assume an even higher rate. 16 Evidence for variation in incidence rates of IBD by race among U.S. children is even more rare 17 with a similar trend in the ratio of cases of IBD lower among blacks and Hispanics compared with whites.…”

Section: Epidemiology Of Ibdmentioning

confidence: 99%

Challenges in Designing a National Surveillance Program for Inflammatory Bowel Disease in the United States

Long

Hutfless

Kappelman

et al. 2014

Inflammatory Bowel Diseases

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This review describes the history of US government funding for surveillance programs in IBD, provides current estimates of the incidence and prevalence of inflammatory bowel diseases (IBD) in the United States (US), and enumerates a number of challenges faced by current and future IBD surveillance programs. A rationale for expanding the focus of IBD surveillance beyond counts of incidence and prevalence, in order to provide a greater understanding of the burden of IBD, disease etiology and pathogenesis, is provided. Lessons learned from other countries are summarized, as well as potential resources that may be used to optimize a new form of IBD surveillance in the US. A consensus recommendation on the goals and available resources for a new model for disease surveillance are provided. This new model should focus upon “surveillance of the burden of disease,” including 1) natural history of disease and 2) outcomes and complications of the disease and/or treatments.

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“…Inflammatory bowel diseases (IBD), consisting of Crohn’s disease and ulcerative colitis, are chronic, immune-mediated diseases of the gastrointestinal tract affecting approximately 71 out of 100,000 youth in the United States (Kappelman et al, 2007) with rising rates of incidence (Malaty, Fan, Opekun, Thibodeaux, & Ferry, 2010). IBD is characterized by unpredictable symptom flares that include abdominal pain, diarrhea, rectal bleeding, weight loss, growth and pubertal delay, fever, fatigue, and arthritis (Mackner, Sisson, & Crandall, 2004).…”

mentioning

confidence: 99%

Stability of Emotional and Behavioral Functioning in Youth with Inflammatory Bowel Disease

Reed-Knight

Lobato

Hagin

et al. 2014

Children's Health Care

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This study prospectively examined stability of psychological and behavioral functioning in two matched cohorts of youth with inflammatory bowel disease (IBD): (1) newly-diagnosed and (2) previously-diagnosed patients. Youth and their parents completed measures of emotional and behavioral functioning at Time 1 and 6-months later. Mean-level analyses indicated that scores at Time 1 and Time 2 were within the nonclinical range. A significant decrease occurred in Internalizing symptoms for previously-diagnosed patients. Both groups demonstrated high levels of profile stability, with no significant differences across groups. Results suggest that emotional and behavioral functioning is generally stable without targeted intervention.

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Rising Incidence of Inflammatory Bowel Disease Among Children: A 12‐year Study

Abstract: The results demonstrate the rising incidence of IBD among children with evidence of more CD than UC. Recognition of these results will have important implications for diagnosis and management of IBD in children.

Cited by 191 publications

References 40 publications

Increasing Hospitalizations in Inflammatory Bowel Disease Among Children in the United States, 1988–2011

Increasing Hospitalizations in Inflammatory Bowel Disease Among Children in the United States, 1988–2011

Challenges in Designing a National Surveillance Program for Inflammatory Bowel Disease in the United States

Stability of Emotional and Behavioral Functioning in Youth with Inflammatory Bowel Disease

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