Right Unilateral Ultrabrief Pulse ECT in Geriatric Depression: Phase 1 of the PRIDE Study

Kellner, Charles H.; Husain, Mustafa M.; Knapp, Rebecca G.; McCall, W. Vaughn; Petrides, Georgios; Rudorfer, Matthew V.; Young, Robert C.; Sampson, Shirlene; McClintock, Shawn M.; Mueller, Martina; Prudic, Joan; Greenberg, Robert M.; Weiner, Richard D.; Bailine, Samuel H.; Rosenquist, Peter B.; Raza, Ahmad; Kaliora, Styliani; Latoussakis, Vassilios; Tobias, Kristen G.; Briggs, Mimi C.; Liebman, Lauren S.; Geduldig, Emma T.; Teklehaimanot, Abeba; Lisanby, Sarah H.

doi:10.1176/appi.ajp.2016.15081101

Cited by 201 publications

(123 citation statements)

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“…(Kellner et al, 2016) Recruitment occurred at multiple sites, and approval for the study was obtained from the institutional review board (IRB) at each study site. Participants provided their own, written, informed consent.…”

Section: Methodsmentioning

confidence: 99%

Effects of a right unilateral ultrabrief pulse electroconvulsive therapy course on health related quality of life in elderly depressed patients

McCall

Lisanby

Rosenquist

et al. 2017

Journal of Affective Disorders

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Introduction Patients with Major Depressive Disorder (MDD) referred for electroconvulsive therapy (ECT) have poorer Health Related Quality of Life (HRQOL), compared with other patients with MDD, but ECT is associated with significant and durable improvement in HRQOL. However, no prior research has focused exclusively on elderly patients with MDD receiving ECT. Methods HRQOL data from 240 depressed patients over the age of 60 was measured with the Medical Outcomes Study Short Form 36 (SF-36). The SF-36 was measured before and after a course of acute ECT. Predictors of change in HRQOL scores were identified by generalized linear modeling. Results At baseline, participants showed very poor HRQOL. After treatment with ECT, the full sample showed marked and significant improvement across all SF-36 measures, with the largest gains seen in dimensions of mental health. Across all participants, the Physical Component Summary (PCS) score improved by 2.1 standardized points (95% CI, 0.61,3.56), while the Mental Component Summary (MCS) score improved by 12.5 points (95% CI, 7.2,10.8) Compared with non-remitters, remitters showed a trend toward greater improvement in the PCS summary score of 2.7 points (95%CI, −0.45, 5.9), while the improvement in the MCS summary score was significantly greater (8.5 points, 95% CI, 4.6,12.3) in the remitters than non-remitters. Post-ECT SF-36 measurements were consistently and positively related to baseline scores and remitter/non-remitter status or change in depression severity from baseline. Objective measures of cognitive function had no significant relationships to changes in SF-36 scores. Limitations This study’s limitations include that it was an open label study with no comparison group, and generalizability is limited to elderly patients. Discussion ECT providers and elderly patients with MDD treated with ECT can be confident that ECT will result in improved HRQOL in the short-term. Attaining remission is a key factor in the improvement of HRQOL. Acute changes in select cognitive functions were outweighed by improvement in depressive symptoms in determining the short term HRQOL of the participants treated with ECT.

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Section: Methodsmentioning

confidence: 99%

Effects of a right unilateral ultrabrief pulse electroconvulsive therapy course on health related quality of life in elderly depressed patients

McCall

Lisanby

Rosenquist

et al. 2017

Journal of Affective Disorders

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“…Electroconvulsive therapy (ECT) is an effective and safe treatment option for specific forms of depression, such as treatment-resistant depression, psychotic depression or melancholia in both uni-and bipolar affective disorder [1,2] with response rates usually ranging around 70%. Despite this remarkable efficacy even in highly treatment-resistant depression, there is still a considerable group of non-responders to ECT.…”

Section: Introductionmentioning

confidence: 99%

Biomarkers for Antidepressant Efficacy of Electroconvulsive Therapy: An Exploratory Cerebrospinal Fluid Study

et al. 2018

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Background: No candidate biomarkers based on cerebrospinal fluid (CSF) have been identified as prognostic factors in patients with major depression treated with electroconvulsive therapy (ECT), yet. Method: Following different underlying hypotheses, we analysed baseline CSF levels of markers of neurodegeneration (tau proteins, β-amyloids and neurogranin), elements of the innate immune system (interleukin [IL]-6, neopterin, soluble CD14, soluble CD163, migration inhibitory factor and monocyte chemotactic protein 1), endocannabinoids, sphingolipids and Klotho before ECT in patients with depression (n = 12) to identify possible correlations with the clinical antidepressant response to ECT. Results: Correlation with the reduction of the depressive symptoms could be observed especially for markers of neurodegeneration and elements of the innate immune system. Differences for CSF levels of several markers were found between the groups of responders and non-responders at the trend level. Limitations: The sample size is small and the distribution of responders and non-responders is uneven. Conclusions: It is this first study on CSF biomarkers for antidepressant efficacy of ECT warrants further research regarding the mechanism of ECT and personalized antidepressant therapy.

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“…Modern ECT is adequately tolerated (Versiani et al, 2011); the rate of conversion to mania is low (Bailine et al, 2010), and cognitive side effects are minimized when current recommendations regarding technique and monitoring are followed (Sackeim and Prudic, 2005; Kellner et al, 2016). …”

Section: Introductionmentioning

confidence: 99%

Speed of antidepressant response to electroconvulsive therapy in bipolar disorder vs. major depressive disorder

Agarkar

Hurt

Young

2018

Psychiatry Research

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Aims We reviewed studies that reported speed of antidepressant response to electroconvulsive therapy (ECT) in both bipolar depression (BPD) and major depressive disorder (MDD). Methods We identified English language reports allowing this comparison. Results Ten studies met our criteria. Four reported significantly faster response in BPD and in one there was trend for faster response. None reported evidence for slower response in BPD. Conclusion The findings support further study of speed of response to ECT in BPD.

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Right Unilateral Ultrabrief Pulse ECT in Geriatric Depression: Phase 1 of the PRIDE Study

Cited by 201 publications

References 39 publications

Effects of a right unilateral ultrabrief pulse electroconvulsive therapy course on health related quality of life in elderly depressed patients

Effects of a right unilateral ultrabrief pulse electroconvulsive therapy course on health related quality of life in elderly depressed patients

Biomarkers for Antidepressant Efficacy of Electroconvulsive Therapy: An Exploratory Cerebrospinal Fluid Study

Speed of antidepressant response to electroconvulsive therapy in bipolar disorder vs. major depressive disorder

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