Rifampicin Hepatitis

Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis

“…All 11 patients in the series described by Scheuer et al were prescribed 450-600 mg daily. 14 The two patients described by Bachs et al received an initial dose of 10 mg/kg/day. 23 To our knowledge there have been no reports of the effect of rifampicin dose on hepatotoxicity in monotherapy.…”

“…Although there have been no published reports of significant additional liver dysfunction in PBC patients treated with rifampicin, concerns remain regarding its safety in PBC, given the described incidence of de novo hepatoxicity when this agent is used as an antimicrobial. [14][15][16][17] Following a case of severe rifampicin hepatotoxicity in our patient cohort, we reviewed the notes of all patients in our practice who had been treated with rifampicin (n=41) to study the frequency of rifampicin induced hepatotoxicity. We examined patient records to identify individuals with a 50% increase in their liver function tests (bilirubin, alanine transaminase, or alkaline phosphatase) following commencement of rifampicin therapy.…”

Rifampin is safe for treatment of pruritus due to chronic cholestasis: a meta‐analysis of prospective randomized‐controlled trials

“…Reports of hepatotoxicity associated with rifampin have warranted its cautious use. However, most of the liver‐related side effects were reported in patients who were treated for tuberculosis with combination of drugs, which included rifampin (9–11). Five prospective randomized‐controlled cross‐over trials have been conducted to establish the efficacy of rifampin for treatment of pruritus associated with chronic cholestasis.…”

Alternative treatment of psoriasis - is rifampicin a mild immunosupressor? / Alternativna terapija psorijaze: da li rifampicin ima blago imunosupresivno dejstvo?

“…rifampicin is administered for more than a year. Data on its side effects and drug interactions have been reported for more than 35 years of clinical experience (29)(30)(31)(32). We used rifampicin in psoriasis patients for 6 months.…”