volume 93, issue 0, P2-P-258 2020
DOI: 10.1254/jpssuppl.93.0_2-p-258
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Abstract: Rhynchophylline (Rhy) is a major active component of Uncaria rhynchophylla and shows the potential to inhibit the proliferation of airway smooth muscle cells (ASMCs). In the current study, it was hypothesized that Rhy played a key role in the anti-asthma effect of Uncaria rhynchophylla via the inhibition of TGF-β1-induced Smad and MAPK signaling. The effect of Rhy on allergic asthma mice and the changes of TGF-β1-induced Smad and MAPK signaling under Rhy administration was detected to underlie the mechanism as…

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