Rhodomyrtone: A new candidate as natural antibacterial drug from Rhodomyrtus tomentosa

Limsuwan, Surasak; Trip, Erik N.; Kouwen, Thijs R. H. M.; Piersma, Sjouke; Hiranrat, Asadhawut; Mahabusarakam, Wilawan; Voravuthikunchai, Supayang Piyawan; Dijl, Jan Maarten van; Kayser, Oliver

doi:10.1016/j.phymed.2009.01.010

Cited by 170 publications

(123 citation statements)

References 12 publications

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“…The compound demonstrated powerful in vitro activity against a broad range of Gram-positive bacteria, including antibiotic-resistant strains [32]. The crude ethanol extract and purerhodomyrtone showed substantial antibacterial activity against Gram-positive bacteria, viz., including Bacillus cereus, Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, methicillinresistant S. aureus, Staphylococcus epidermidis, Streptococcus gordonii, Streptococcus mutans, Streptococcus pneumoniae, Streptococcus pyogenes, and Streptococcus salivarius [5]. Further, rhodomyrtone exhibited stronger antibacterial activity than vancomycin.…”

Section: Antibacterial Activitymentioning

confidence: 96%

“…Jeenkeawpieam et al [39] reported that endophytic fungi from R. tomentosa can be a good source of potential antifungal natural (2) [26] Rhodomyrtosones A-C (3)(4)(5) [23] Rhodomyrtosone D (6) [27] Tomentosone A (7) [27] Tomentosone B (8) [26] Flavonoid…”

Section: Antifungal Activitymentioning

confidence: 99%

“…Historically, R. tomentosa has been used in traditional Vietnamese, Chinese, and Malaysian medicine to treat diarrhea or dysentery, as well as stimulate the immune system [4]. Recently, the ethanol extract of R. tomentosa leaves and rhodomyrtone, its principle compound, have been demonstrated to have excellent antibacterial activity against Gram-positive bacteria [5]. However, little information is available in the literature concerning the chemical constituents and pharmacological activity of R. tomentosa.…”

Section: Introductionmentioning

confidence: 99%

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Rhodomyrtus Tomentosa: A Phytochemical and Pharmacological Review

Hamid

Zeyohannes²,

Yusoff³

2016

Asian J Pharm Clin Res

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Rhodomyrtus tomentosa is a common wood, prevalent in areas with undemanding soil conditions and resistant toward pests and diseases. The plant can be found in China, Taiwan, Philippines, Malaysia, Indonesia, and Vietnam. Literature and artwork indicate that R. tomentosa played an important holistic role in the daily lives of several ancient cultures, providing medicinal benefits. R. tomentosa exhibits a wide spectrum of pharmacological effects and has been used to treat colic diarrhea, wounds, heartburn, abscesses, gynecopathy, and as a pain killer. R. tomentosa was used in traditional Chinese medicine to treat urinary tract infection. 42 compounds have been isolated from this plant and structurally elucidated. They comprise phloroglucinol, flavonoid, terpenoid, anthracene glycoside, tannin, and other compounds. Rhodomyrtone, a member of the acylphloroglucinols demonstrated a significant activity against a wide range of Gram-positive bacteria. Rhodomyrtone exhibited both antimicrobial and anti-infective activities. Several biological activities have been documented as antibacterial, antifungal, antimalarial, osteogenic, antioxidant, and anti-inflammatory. R. tomentosa has been studied extensively for alternative antimicrobial agents. Although rhodomyrtone exhibited potential activity with a very low minimum inhibitory concentration value, the mechanisms of action of this compound are still unclear. Furthermore, toxicity studies on it extract to validate pharmacological activities are required.

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Section: Antibacterial Activitymentioning

confidence: 96%

Section: Antifungal Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Rhodomyrtus Tomentosa: A Phytochemical and Pharmacological Review

Hamid

Zeyohannes²,

Yusoff³

2016

Asian J Pharm Clin Res

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“…And developments of new antimicrobial agents whenever resistant bacteria appear have been repeated [11][12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and antifungal activities of isoprenoids

Nagaki

Narita

Ichikawa

et al. 2011

Trans. Mat. Res. Soc. Japan

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We assayed biologically significant isoprenoids for antibacterial and antifungal activities. Isoprenoids varied widely with respect to their growth inhibitory activities towards Gram-positive and Gram-negative bacteria and fungal species. Of particular interest was the finding that geraniol acted as a broad spectrum of antibiotic, and significantly inhibited the growth of Gram-positive Staphylococcus aureus 209P and methicillin resistant S. aureus 834, Gram-negative Escherichia coli IFO-3806, and Shigella sonnei, as well as the fungus Trichopyton sp. Farnesol inhibited S. aureus strains 209P and 834 to a greater extent than did geraniol, but did not detectably inhibit Gram-negative bacteria.

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“…The synthesis of xanthenes and their derivatives has received significant attention due to their various pharmacological activities, such as antibacterial and antifungal (Limsuwan et al, 2009;Omolo et al, 2011), analgesic and anti-inflammatory (Hafez et al, 2008;Banerjee et al, 2011), anti-viral (Jamison et al, 1990Naidu et al, 2012), antioxidant (Nishiyama et al, 1998), anti-cancer (Chatterjee et al, 1996;Song et al, 2013), cytotoxic (Bhattacharya et al, 2009) and antiproliferative properties (Kumar et al, 2010). These compounds have also been employed as sensitisers in photodynamic therapy (Neckers, 1989;Gutiérrez & García, 1998;Chang et al, 2008), in the food industry as additives (Tanaka, 2001;Chequer et al, 2012;Odo et al, 2012;Qi et al, 2012), in laser technologies (Ahmad et al, 2002;De et al, 2005) and as fluorescent materials for the visualisation of biomolecules (Knight & Stephens, 1989;Liu et al, 2001;Hilderbrand & Weissleder, 2007).…”

Section: Introductionmentioning

confidence: 99%