Rhodiola rosea root extract has antipsychotic-like effects in rodent models of sensorimotor gating

Coors, Andreas; Brosch, Marcel; Kahl, Evelyn; Khalil, R; Michels, Birgit; Laub, Annegret; Franke, Katrin; Gerber, Bertram; Fendt, Markus

doi:10.1016/j.jep.2019.02.031

Cited by 18 publications

(11 citation statements)

References 58 publications

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“…R. rosea effects were recently evaluated in murine models of prepulse inhibition, an established operational measure of sensorimotor gating which is impaired in a variety of mental disorders featuring psychosis [156]. In detail, R. rosea extract robustly reverses prepulse inhibition deficits which are induced by either the dopamine D2 receptor agonist apomorphine or the NMDA receptor antagonist dizocilpine.…”

Section: Prepulse Inhibition-related Depression and Psychosismentioning

confidence: 99%

“…In detail, R. rosea extract robustly reverses prepulse inhibition deficits which are induced by either the dopamine D2 receptor agonist apomorphine or the NMDA receptor antagonist dizocilpine. Thus, R. rosea may possess antipsychotic effects, though the underlying molecular mechanisms remain to be elucidated [156].…”

Section: Prepulse Inhibition-related Depression and Psychosismentioning

confidence: 99%

“…Antioxidants 2020, 9, x FOR PEER REVIEW 15 of 32 featuring psychosis [156]. In detail, R. rosea extract robustly reverses prepulse inhibition deficits which are induced by either the dopamine D2 receptor agonist apomorphine or the NMDA receptor antagonist dizocilpine.…”

Section: Prepulse Inhibition-related Depression and Psychosismentioning

confidence: 99%

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Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea

et al. 2020

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Recent studies focused on the pharmacology and feasibility of herbal compounds as a potential strategy to target a variety of human diseases ranging from metabolic to brain disorders. Accordingly, bioactive ingredients which are found within a variety of herbal compounds are reported to produce both neuroprotective and psychotropic activities which may help to combat mental disorders such as depression, anxiety, sleep disturbances and cognitive alterations. In the present manuscript, we focus on three herbs which appear effective in mitigating anxiety or depression with favourable risk-benefit profiles, namely Scutellaria baicalensis (S. baicalensis), Hericium erinaceus (H. erinaceus) and Rhodiola rosea (R. rosea). These three traditional folk medicinal herbs target the main biochemical events that are implicated in mental disorders, mimicking, to some extent, the mechanisms of action of conventional antidepressants and mood stabilizers with a wide margin of tolerability. In detail, they rescue alterations in neurotransmitter and neuro-endocrine systems, stimulate neurogenesis and the synthesis of neurotrophic factors, and they counteract oxidative stress, mitochondrial dysfunction and inflammation. Albeit the encouraging results that emerge from both experimental and clinical evidence, further studies are needed to confirm and better understand the mental-health promoting, and specifically, the antidepressant effects of these herbs.

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Section: Prepulse Inhibition-related Depression and Psychosismentioning

confidence: 99%

Section: Prepulse Inhibition-related Depression and Psychosismentioning

confidence: 99%

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Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea

et al. 2020

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“…This information suggests that an antioxidant, anti-inflammatory, antidepressant and anxiolytic agent may be effective in the treatment of stress-induced infertility and pathologies affecting reproductive processes. Rhodiola rosea root extract (RRE) used in the study is obtained from the root of Rhodiola rosea L. plant [17], which grows in the northern parts of Europe, Asia and the US. Preclinical studies have reported that RRE has anti-stress, neuropsychotropic, anxiolytic, antidepressant and neuroprotective effects [17,18].…”

Section: Introductionmentioning

confidence: 99%

“…Rhodiola rosea root extract (RRE) used in the study is obtained from the root of Rhodiola rosea L. plant [17], which grows in the northern parts of Europe, Asia and the US. Preclinical studies have reported that RRE has anti-stress, neuropsychotropic, anxiolytic, antidepressant and neuroprotective effects [17,18]. In addition, Rhodiola rosea extract has antioxidant and anti-inflammatory effects [19,20].…”

Section: Introductionmentioning

confidence: 99%

The effect of rhodiola rosea root extract on stress-induced ovarian damage, infertility and reproductive disorders in female rats

Kadıoğlu¹,

Gündoğdu²,

Kurt³

et al. 2020

Clinical and Experimental Obstetrics & Gynecology

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The aim of the study was to examine the possible effect of Rhodiola rosea root extract (RRE) on ovarian damage, infertility (IF), delay in conception (DC), decrease in the number of offspring (NO) in female rats that have been stressed with compulsory immobilization method (CIM) and on retardation of intrauterine physical development (IPD) in offspring. Materials and methods: Female Albino Wistar rats were divided like: healthy (HG), stress-induced control (SC), and stress + 50 mg/kg RRE (S + REG) groups including sixteen rats in each group. Six rats from each group were killed for conducting biochemical and histopathological examinations in ovarian tissues and others were observed for IF, DC, NO, and IPD. Results: It was found that RRE significantly prevented the increase in oxidative parameters and proinflammatory cytokine levels in ovarian tissue of animals stressed with CIM. RRE suppressed the increase in IF rate and DC whereas caused a decrease in NO and in IPD retardation. Conclusion: These results suggested RRE may have beneficial effects in the treatment of stress induced reproductive dysfunction. Content: The effect of RRE on oxidative and inflammatory changes in ovarian tissue and reproductive changes of animals exposed to stress with compulsory immobilization method.

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Reshaped Gut Microbial Composition and Functions Associated with the Antifatigue Effect of Salidroside in Exercise Mice

Zhu

Shen²,

Wang

et al. 2023

Molecular Nutrition Food Res

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Scope Salidroside (SA) is an active compound derived from Rhodiola rosea and is widely used in healthcare foods. However, the underlying mechanism and its specific role in regulating the gut microbial community during exercise (Ex) remains unknown. Methods and results Mice are subjected to a weight‐loaded swimming test (WST) Ex to determine how gut microbiota affects the antifatigue activity of SA. The SA‐treated group mice (100 mg kg−1.bw.) display a significant increase in swimming time compared to the control group (26.2 versus 10.5 min, p < 0.01), as well as an increase in respiratory enzymatic activities after swimming. The respiratory enzymatic activities are significantly higher in the SA‐treated group than in the RS (regular rest) group after swimming. The bacteria profiles in the Ex + SA group change significantly with higher species diversity and abundance. Receiver operating characteristic (ROC) curves of Alistipes, Rikenellaceae, Parabacteroides, Candidatus Arthromitus, and Lactobacillus indicate a high diagnostic utility to distinguish SA treatment. Microbial function analysis shows that SA may improve Ex‐induced fatigue by modulating energy metabolism‐related processes. Conclusions SA demonstrates antifatigue effects on various levels of regulating energy metabolism and microbial composition, providing insights into the underlying mechanisms of SA as a natural prebiotic.

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Rhodiola rosea root extract has antipsychotic-like effects in rodent models of sensorimotor gating

Cited by 18 publications

References 58 publications

Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea

Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea

The effect of rhodiola rosea root extract on stress-induced ovarian damage, infertility and reproductive disorders in female rats

Reshaped Gut Microbial Composition and Functions Associated with the Antifatigue Effect of Salidroside in Exercise Mice

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