"Rheumatoid" Nodules of the Skin

Lowney, Edmund D.

doi:10.1001/archderm.1963.01590240177030

Cited by 48 publications

(7 citation statements)

References 12 publications

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“…T h e former was ruled out by normal serum urate levels, normal 244hour urinary uric acid excretion, and absence of urqte crystals in aspirates of a nodule and olecranon bursa and histologic section of a nodule; the latter was excluded by histologic examination. It is noteworthy that in similar cases (9,11,13) similar diagnoses were enkertained.…”

Section: Discussionsupporting

confidence: 60%

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Rheumatoid nodulosis an unusual variant of rheumatoid disease

Ginsberg

Genant

et al. 1975

Arthritis & Rheumatism

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A middle-aged man developed multiple subcutaneous nodules associated with palindromic rheumatism. There was little evidence of synovitis; however multiple cyst-like intraosseous radiolucencies were noted. Nodules from two sites were histologically typical rheumatoid nodules. Subjective and objective improvement occurred during penicillamine therapy. This clinical presentation seems sufficiently distinctive to warrant characterization as a variant of rheumatoid disease termed by us: rheumatoid nodulosis.

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Section: Discussionsupporting

confidence: 60%

“…Subcutaneous granulomata, histologically indistinguishable from rheumatoid nodules, have been well described in otherwise healthy children (1-7); but reports of such nodules in adults without frank rheumatoid synovitis or systemic lupus erythematosus have been less frequent (8)(9)(10)(11)(12).…”

mentioning

confidence: 99%

Rheumatoid nodulosis an unusual variant of rheumatoid disease

Ginsberg

Genant

et al. 1975

Arthritis & Rheumatism

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“…Rheumatoid nodules can precede arthritis by a few years. However, it is rare to have rheumatoid nodules for several years with no signs of joint disease 16 . There is insufficient evidence to define a time period over which follow up can exclude arthritis.…”

Section: Discussionmentioning

confidence: 99%

“…There is insufficient evidence to define a time period over which follow up can exclude arthritis. Joint symptoms have been reported to first arise more than 10 years after the presentation of rheumatoid nodules 16 …”

Section: Discussionmentioning

confidence: 99%

Rheumatoid nodules without arthritis

Hewitt

Cole

2005

Aust J Dermatology

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A 53-year-old man presented with firm, non-tender subcutaneous nodules overlying his hands and elbows. These had been progressive in number and size over 7 years. Rheumatoid factor was negative but a biopsy was consistent with rheumatoid nodules. He has never had any joint symptoms and remains otherwise asymptomatic. Examination is unremarkable except for the nodules described. We believe this man has rheumatoid nodules with no evidence of arthritis.

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“…Rheumatoid nodules are observed in approximately 20% of patients suffering from rheumatoid arthritis 83,84 . They are localized not only to cutaneous and subcutaneous tissues, but can also be found in the heart, lungs, pericardium, myocardium, larynx, eyes, nose and peritoneum 83,84 …”

Section: Aetiopathogenetic Aspectsmentioning

confidence: 99%

Sarcoidosis of the skin – A dermatological puzzle: important differential diagnostic aspects and guidelines for clinical and histopathological recognition

Tchernev¹,

Nenoff³

et al. 2010

Acad Dermatol Venereol

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Sarcoidosis of the skin may have an extremely heterogeneous clinical presentation, so that the definitions of 'great imitator' and 'clinical chameleon' have long been used. There is, in fact, a large group of skin diseases that can enter the differential diagnosis with cutaneous sarcoid manifestations, either clinically or/and pathologically. As the clinical consequences and the prognosis of these groups of diseases are often very different, it is important to correctly plan the diagnostic workup. The diagnostic process in this case often presents a challenge as no single test is sufficiently specific, so that a certain diagnosis can be only made in the presence of a compatible clinical and radiographic picture, along with histopathological evidence of non-necrotizing, epithelioid cell granulomas, and exclusion of other potential aetiologies. For practical reasons, four main groups of skin conditions capable of mimicking sarcoidosis can be identified: (i) transmissible, infectious diseases; (ii) allergic and immunological manifestations of various aetiologies; (iii) granulomatous diseases of various aetiologies; and (iv) lymphomas and pseudolymphomas. The aim of this article is to describe the main clinical and histopathological findings of such disease entities, and to discuss the role of those features (morphological, pathological and laboratory) that can help distinguish them from sarcoidosis of the skin.

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"Rheumatoid" Nodules of the Skin

Cited by 48 publications

References 12 publications

Rheumatoid nodulosis an unusual variant of rheumatoid disease

Rheumatoid nodulosis an unusual variant of rheumatoid disease

Rheumatoid nodules without arthritis

Sarcoidosis of the skin – A dermatological puzzle: important differential diagnostic aspects and guidelines for clinical and histopathological recognition

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