Rheumatoid Arthritis: A Brief Overview of the Treatment

Bullock, Jacqueline; Rizvi, Syed A. A.; Saleh, Ayman; Ahmed, Sultan; Duc, Philippe; Ansari, Rais A.; Ahmed, Jasmin

doi:10.1159/000493390

Cited by 461 publications

(354 citation statements)

References 46 publications

Supporting

Mentioning

273

Contrasting

Unclassified

Order By: Relevance

“…Non‐steroidal anti‐inflammatory drugs and disease‐modifying anti‐rheumatoid drugs are widely used to treat the disease but always associated with some intolerable side effects . Biologicals, such as etanercept, require high payment and increase the risk of serious infections that cannot be ignored .…”

Section: Introductionmentioning

confidence: 99%

Evodiamine attenuates adjuvant-induced arthritis in rats by inhibiting synovial inflammation and restoring the Th17/Treg balance

Zhang

et al. 2020

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Objectives Evodiamine (Evo) possesses strong anti-inflammatory activity. In this study, we determine the antiarthritic effect of Evo. Methods Evo was administered to rats with adjuvant-induced arthritis (AA). We evaluated arthritis symptoms & histopathological changes and measured inflammatory cell infiltration, pro-inflammatory cytokine production and Th17 & Treg percentages in arthritic rats. Key findings Evo significantly improved the clinical signs of AA in rats, including decreases in paw swelling, the polyarthritis index and the number of swollen paw joints. Based on the histopathological analysis, Evo improved synovial inflammation and bone injury by inhibiting inflammatory cell infiltration, synoviocyte proliferation, pannus formation and cartilage erosion. Furthermore, the numbers of synovial CD3+ or CD68+ inflammatory cells were reduced, and the elevated levels of tumour necrosis factor-a, interleukin-1b (IL-1b) and IL-6 were restored to control levels by the Evo treatment. In addition, Evo therapy regulated the abnormal differentiation of Treg and Th17 cells, decreasing IL-17 production and increasing IL-10 levels. Finally, Evo inhibited Stat3 phosphorylation and induced Stat5 phosphorylation in rats with AA. Conclusions Based on our results, Evo is a promising antiarthritic agent, potentially due to its inhibitory effect on synovial inflammation and regulatory effects on Treg and Th17 differentiation.

show abstract

Section: Introductionmentioning

confidence: 99%

Evodiamine attenuates adjuvant-induced arthritis in rats by inhibiting synovial inflammation and restoring the Th17/Treg balance

Zhang

et al. 2020

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…The first clinical trial targeting PDGFR in DSRCT was using a small molecule inhibitor called SU101 or leflunomide and resulted in one patient out of 2 with DSRCT experiencing stable disease for more than 12 months before disease progression (36) Lenflunomide is not being developed further as an anti-sarcoma agent, but has been used as an immunosuppressant for treatment of rheumatoid arthritis (55).…”

Section: Platelet-derived Growth Factor Receptor Pathway In Dsrsctmentioning

confidence: 99%

Mini-Review on Targeted Treatment of Desmoplastic Small Round Cell Tumor

2020

View full text Add to dashboard Cite

Desmoplastic small round cell tumor (DSRCT) is a devastating disease which most commonly affects adolescents, with a male predominance. Despite the best multimodality treatment efforts, most patients will ultimately not survive more than 3-5 years after diagnosis. Some research trials in soft-tissue sarcoma and Ewing sarcoma include DSRCT patients but few studies have been tailored to the specific clinical needs and underlying cytogenetic abnormalities characterizing this disease such as the typical EWSR1-WT1 gene fusion. Downstream activation of EWSR1-WT1 gene fusion includes signaling pathways of platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and insulin growth factor (IGF)-1. Other biological pathways that are activated and expressed in DSRCT cells include endothelial growth factor receptor (EGFR), androgen receptor pathway, c-KIT, MET, and transforming growth factor (TGF) beta. Investigation of somatic mutations, copy number alterations (CNA), and chromosomes in DSRCT samples suggests that deregulation of mesenchymal-epithelial reverse transition (MErT)/epithelial-mesenchymal transition (EMT) and DNA damage repair (DDR) may be important in DSRCT. This mini review looks at known druggable targets in DSRCT and existing clinical evidence for targeted treatments, particularly multityrosine kinase inhibitors such as pazopanib, imatinib, and sorafenib alone or in combination with other agents such as mTOR (mammalian target of rapamycin) inhibitors. The aim is to increase shared knowledge about current available treatments and identify gaps in research to further efforts toward clinical development of targeted agents.

show abstract

“…Uric acid and allantoin are both important metabolites in the arginine and proline metabolism. RA affects not only the joints, but also internal organs [24]. Patients with RA often have kidney damage.…”

Section: Arginine and Proline Metabolismmentioning

confidence: 99%

A wide‐targeted urinary and serum metabolomics strategy reveals the effective substance of the Wu‐tou decoction

Cheng

et al. 2019

J of Separation Science

View full text Add to dashboard Cite

As an important Chinese medicine decoction, Wu‐tou decoction has been used to treat rheumatic arthritis for more than a thousand years. We previously reported that the Wu‐tou decoction could change the urinary and serum metabolites in adjuvant‐induced arthritis rats significantly. The purpose of this research was to confirm the potential biomarkers obtained by previous non‐targeted metabolomics study through quantitative analysis by liqui chromatography with tandem mass spectrometry, in the meantime, to further study the effective material basis of Wu‐tou decoction. Firstly, the important compounds in the tryptophan metabolism pathway, the arginine and proline metabolism pathway, the amino acid metabolism pathway, the tricarboxylic acid cycle, the vitamin B6 metabolism pathway, and the phenylalanine metabolism pathway, which were identified as potential biomarkers in previous study, were selected for quantitative analysis. Then the linearity, limit of detection, limit of quantification, selectivity, accuracy, precision, stability, recovery, and matrix effect of the quantitative method were examined. Finally, ten and eighteen metabolites were quantitatively analyzed in the serum and urine, respectively. The results showed that seven out of ten serum potential biomarkers and ten out of eighteen urine potential biomarkers were confirmed as real biomarkers. This research provides a powerful reference for the study on effective material basis of Wu‐tou decoction.

show abstract

Rheumatoid Arthritis: A Brief Overview of the Treatment

Cited by 461 publications

References 46 publications

Evodiamine attenuates adjuvant-induced arthritis in rats by inhibiting synovial inflammation and restoring the Th17/Treg balance

Evodiamine attenuates adjuvant-induced arthritis in rats by inhibiting synovial inflammation and restoring the Th17/Treg balance

Mini-Review on Targeted Treatment of Desmoplastic Small Round Cell Tumor

A wide‐targeted urinary and serum metabolomics strategy reveals the effective substance of the Wu‐tou decoction

Contact Info

Product

Resources

About