Rheological characterization of a charged cationic hydrogel network across the gelation boundary

Şahiner, Nurettin; Singh, Mohit; Kée, D. De; John, Vijay T.; McPherson, Gary L.

doi:10.1016/j.polymer.2005.10.129

Cited by 60 publications

(44 citation statements)

References 44 publications

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“…Rapid relaxation times help ensure that a biomaterial rapidly reverts to its equilibrium state, and subsequently reduce the number of variables that can influence the performance of a therapeutic hydrogel in vivo. The MPEG-pDHA gels display rapid relaxation times (250-350 s), which also increase with increasing pDHA chain length and entanglement density (Table 1) (44). Materials and Methods includes the equations that were used to calculate the MPEG-pDHA hydrogel relaxation times.…”

Section: Resultsmentioning

confidence: 99%

Design of an injectable synthetic and biodegradable surgical biomaterial

Zawaneh¹,

Singh

Padera

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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We report the design of an injectable synthetic and biodegradable polymeric biomaterial comprised of polyethylene glycol and a polycarbonate of dihydroxyacetone (MPEG-pDHA). MPEG-pDHA is a thixotropic physically cross-linked hydrogel, displays rapid chain relaxation, is easily extruded through narrow-gauge needles, biodegrades into inert products, and is well tolerated by soft tissues. We demonstrate the clinical utility of MPEG-pDHA in the prevention of seroma, a common postoperative complication following ablative and reconstructive surgeries, in an animal model of radical breast mastectomy. This polymer holds significant promise for clinical applicability in a host of surgical procedures ranging from cosmetic surgery to cancer resection.hydrogel | seroma prevention | dihydroxyacetone | surgical biomaterial P olymeric biomaterials have contributed significantly to the advancement of medical and surgical practice over the past few decades. Their macromolecular structure can be tailored to provide the appropriate combination of chemical, physical, and biological properties necessary for a range of medical and surgical applications. The rational design of polymeric biomaterials has impacted many fields, including drug and gene delivery, orthopedics, tissue engineering, ophthalmology, and general surgery (1-3). The work reported herein focuses on the development of an injectable surgical biomaterial. Its potential impact is demonstrated in the prevention of postoperative seroma.A seroma is an abnormal collection of serous fluid within the tissues of the body, akin to an internal blister. Seroma formation is a common postoperative complication particularly following ablative and reconstructive surgeries. Surgeries that require extensive tissue dissection and create large empty spaces can disrupt normal lymphatic flow. Subsequently, transduate fluid collects in these poorly drained "dead spaces," resulting in formation of a seroma (4, 5). Seromas can lead to significant patient morbidity, such as infection, decreased limb mobility, and reoperation (4, 6, 7). Seroma formation rates range from 9.1% to 81%, depending on the nature of the surgical procedure (6,(8)(9)(10)(11)(12)(13). Notably, modified radical mastectomies lead to seroma formation rates ranging from 15% to 38.6%, and radical mastectomies report a rate as high as 52% (7,(14)(15)(16)(17). In current clinical practice, silicone surgical drains are placed in the wound bed through separate stab incisions to collect transudate fluid, but they can be a significant source of pain and discomfort to patients, especially upon their removal up to several weeks after the initial surgical procedure. Furthermore, they can increase the risk of infection at the surgical site.Several approaches to reduce seroma formation have been investigated. Surgical techniques, such as collapsing the seroma cavity with sutures, do not consistently and adequately eliminate seroma formation (16,18,19). Other methods, such as sclerotherapy (20, 21), compression dressings (22), and biolog...

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Section: Resultsmentioning

confidence: 99%

Design of an injectable synthetic and biodegradable surgical biomaterial

Zawaneh¹,

Singh

Padera

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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“…The polymerization and the crosslonking of p(APTMACl) hydrogels were reported earlier (Sahiner et al, 2006) The schematic presentation of synthesis of p(APTMACl) cryogels is illustrated in Fig. 1(a).…”

Section: Synthesis and Characterization Of P(aptmacl) And Magp(aptmacmentioning

confidence: 99%

The use of superporous p(3-acrylamidopropyl)trimethyl ammonium chloride cryogels for removal of toxic arsenate anions

Şahiner

Demirci

Şahiner

et al. 2015

Journal of Environmental Management

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“…For cross-linked microgel dispersions, G' and G" are exhibited as almost independent of oscillation frequency [61,62]. This technique has been used to characterize the network structure in seroglucan-borax hydrogel [63], chitosan-based cationic hydrogels [64,65], and a range of other hydrocolloids [54].…”

Section: Rheologymentioning

confidence: 99%