2003
DOI: 10.1101/gad.1110003
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Abstract: Tuberous sclerosis complex (TSC) is a genetic disease caused by mutation in either TSC1 or TSC2. The TSC1 and TSC2 gene products form a functional complex and inhibit phosphorylation of S6K and 4EBP1. These functions of TSC1/TSC2 are likely mediated by mTOR. Here we report that TSC2 is a GTPase-activating protein (GAP) toward Rheb, a Ras family GTPase. Rheb stimulates phosphorylation of S6K and 4EBP1. This function of Rheb is blocked by rapamycin and dominant-negative mTOR. Rheb stimulates the phosphorylation … Show more

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Cited by 1,614 publications
(1,360 citation statements)
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“…2003). In addition, the TGF‐beta signaling pathway also was identified in high temperature stress, this pathway has an important regulatory role in development and in extracellular matrix synthesis and would repair (Kingsley 1994), therefore, it might contribute to reduce the level of damaged proteins when spiders are under high temperature stress.…”
Section: Discussionmentioning
confidence: 99%
“…2003). In addition, the TGF‐beta signaling pathway also was identified in high temperature stress, this pathway has an important regulatory role in development and in extracellular matrix synthesis and would repair (Kingsley 1994), therefore, it might contribute to reduce the level of damaged proteins when spiders are under high temperature stress.…”
Section: Discussionmentioning
confidence: 99%
“…These include REDD1 that has been reported to activate the Tuberous Sclerosis Complex 1/2 (TSC1/2) [75]. The TSC1/2 possesses GTPase activating function that renders the mTOR activator RHEB inactive [76]. BNIP3, another known HIF-1 target, has also been reported to facilitate the accumulation of the GDP-bound form of RHEB and the consequent down-regulation of mTOR in hypoxia [77].…”
Section: Crosstalk Between the Hif And Other Regulatory Pathwaysmentioning
confidence: 99%
“…Along with others, we showed that the small GTPase Rheb is the molecular link between TSC1/2 and mTORC1. Rheb activates mTORC1, and TSC2 inhibits Rheb by acting as a GTPase-activating protein (Castro et al, 2003;Garami et al, 2003;Tee et al, 2003;Inoki et al, 2003a;Zhang et al, 2003b).…”
Section: Introductionmentioning
confidence: 99%