Rhabdomyosarcoma Presenting as an Acute Suppurative Mastoiditis

Lee, Carline A.; Aga, Luo; Lie, Qing Yong; Zhao, Lin

doi:10.1016/j.otohns.2003.04.002

Cited by 10 publications

(7 citation statements)

References 2 publications

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“…Twenty-three publications were based on a pooled total of 24 children (<18 years old) with diseases mimicking AM ( Table 2 ). 3,4,8-28 Age ranged from 10 weeks to 16 years with a male predominance (14 males, 8 females, 2 not reported). In total, 11 unique diseases were cited: acute myelogenous leukemia (AML), angiosarcoma, cranial fasciitis, Ewing sarcoma, Kawasaki disease, Langerhans cell histiocytosis (LCH), liposarcoma, melanoma, non-Hodgkin B- and T-cell lymphoma (NHL), and RMS.…”

Section: Resultsmentioning

confidence: 99%

“…Five diseases presented with elevated erythrocyte sedimentation rate or C-reactive protein: cranial fasciitis, 12 NHL, 28,37 Ewing sarcoma, 14 Kawasaki disease, 15 and LCH. 16,18,19,33 AML presented with thrombocytopenia, 10 Ewing sarcoma and NHL with elevated lactate dehydrogenase, 14,37 and GPA with elevated antineutrophil cytoplasmic antibody (c-ANCA) and 23 Romania Non-Hodgkin B-cell lymphoma 4 F Mastoidectomy b Chemotherapy -Vigier 28 France Non-Hodgkin B-cell lymphoma 7 mo F Mastoidectomy b Chemotherapy Remission Ho 24 UK Non-Hodgkin T-cell lymphoma 1 M Mastoidectomy b Chemotherapy Remission Ng 25 Malaysia Rhabdomyosarcoma 1 F Mastoidectomy b Chemotherapy Remission Lee 26 China Rhabdomyosarcoma 2 M I&D b Patient refused -Beghdad 3 Morocco Rhabdomyosarcoma 3 F Mastoidectomy b Chemotherapy Symptom improvement at 1 mo Vasiwala 27 Malaysia protease 3 antibody levels. 32,40 IHC findings are also presented in Table 4.…”

Section: Surgical Interventions and Intraoperative Appearancementioning

confidence: 99%

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A Review of Noninfectious Diseases Masquerading as Acute Mastoiditis

Wong

Arrighi‐Allisan

Fan

et al. 2021

Otolaryngol.--head neck surg.

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Objective Acute mastoiditis is commonly attributed to infection. Rarely do clinicians encounter cases that do not respond to traditional antibiotics or surgical management. The goal of this study was to systematically review the literature to characterize diseases masquerading as acute infectious mastoiditis. Data Sources PubMed, Embase, and Scopus. Review Methods A systematic review was performed to identify all publications that reported on diseases with presentations mimicking acute mastoiditis, defined as postauricular redness, swelling, and tenderness. We included clinical prospective studies, retrospective studies, and case series/reports. Exclusion criteria included non-English articles, letters/commentaries, abstracts, and review articles. Results Out of 3339 results, 35 studies met final inclusion criteria. In children, 11 diseases were reported to mimic mastoiditis, including solid tumors, hematologic diseases, and autoimmune/inflammatory diseases. The most common disease in children was Langerhans cell histiocytosis, followed by rhabdomyosarcoma and acute myelogenous leukemia. In adults, 8 additional diseases were reported. The most common disease in adults was squamous cell carcinoma, followed by nasopharyngeal carcinoma and Langerhans cell histiocytosis. Presenting symptoms are reviewed, as well as characteristic radiographic, laboratory, and intraoperative features that may assist with diagnosis. A diagnostic algorithm for atypical cases of acute mastoiditis is proposed. Conclusion A small but significant group of diseases in children and adults can mimic acute mastoiditis. In such cases, history and examination alone may be insufficient to reach a diagnosis, and further investigation may be necessary. Otolaryngologists should always be mindful of the possibility that noninfectious pathologies may present with a constellation of symptoms similar to mastoiditis.

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Section: Resultsmentioning

confidence: 99%

Section: Surgical Interventions and Intraoperative Appearancementioning

confidence: 99%

A Review of Noninfectious Diseases Masquerading as Acute Mastoiditis

Wong

Arrighi‐Allisan

Fan

et al. 2021

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

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“…The clinical presentation of these tumors originating from the ear might mimic otitis media with a polypoidal mass [ 11 ]. Additionally, the patient might present with palpable lymph nodes [ 12 ]. Patients could have facial nerve involvement due to the erosive nature of the disease [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…In most cases, surgical excision is not a good treatment option because of the involvement of vital structures and intracranial extension [ 6 ]. The overall 5-year survival for localized disease in patient’s aged 1 to 4 years with the embryonal histology type is up to 80% [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Pediatric Patient with Rhabdomyosarcoma Involving Temporal Bone: Case Report and Overview of Recent Cases

et al. 2022

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Objective:Rare disease Background:In the pediatric age group, middle ear tumors are rare. Rhabdomyosarcoma is considered the most common soft-tissue sarcoma in children. It comprises 5% of all pediatric malignant tumors. It is hypothesized to originate from embryonic mesenchymal cells of striated skeletal muscles. These malignant lesions display an aggressive behavior with local and distant metastasis and can be staged as per the Intergroup Rhabdomyosarcoma Study Group, depending on the organs involved, such as the orbit, head, neck, or genitourinary tract. Case Report:In this study, a 2-year-old boy with no medical ailments was presented with a history of ear pain and on/off bleeding from the right ear for 1 year. The patient's case was initially managed medically, for the clinical picture of an ear infection. However, clinical improvement was not seen. Therefore, radiological imaging was done. After further investigations, the diagnosis was confirmed, and a rare case of embryonal rhabdomyosarcoma of the temporal bone was reported. Conclusions:Rhabdomyosarcoma is an uncommon tumor in which delayed diagnosis could cause a significant fatality rate in children. Physicians need a strong index of suspicion to make an early diagnosis. The presented case is of a 2-year-old boy with a clinical picture of a complicated ear infection who was found to have rhabdomyosarcoma of the temporal bone. Early detection and multimodal treatment are critical for a positive outcome.

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“…The most commonly described symptoms of the temporal bone and middle ear rhabdomyosarcomas include the clinical picture of chronic otitis media with effusion, polypoid masses in the external auditory canal, otorrhagia, ear pain with or without signs of the same sided peripheral facial nerve palsy, that all delays the diagnosis. This case report describes a middle ear rhabdomyosarcoma with a clinical picture indicating acute purulent mastoiditis [8].…”

Section: Introductionmentioning

confidence: 99%