Rhabdomyosarcoma presenting as a cutaneous nodule

Wiss, K.

doi:10.1001/archderm.124.11.1687

Cited by 13 publications

(8 citation statements)

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“…32 Nevertheless, our case represents the first example of primary cutaneous RMS with convincing positivity for keratins by immunohistochemistry. In fact, most of the cases reported in literature so far have shown positivity for skeletal markers, such as desmin, 2,5-23,26,27 actins, 2,6,8,[10][11][12][13][14][15][17][18][19][20][21]27 myogenin, 15,18,20,[24][25][26] myoglobin, [4][5][6]8,10,12,16,17,22,25,26 and MyoD1 17,18,26,27 . Some also displayed positivity for vimentin, 6,7,10,11,[13][14][15][17][18][19][20][21]…”

Section: Discussionmentioning

confidence: 99%

Rhabdomyosarcoma of the Skin Resembling Carcinosarcoma: Report of a Case and Literature Review

Scatena¹,

Massi²,

Franchi³

et al. 2012

The American Journal of Dermatopathology

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Rhabdomyosarcomas (RMSs) are soft tissue sarcomas with skeletal muscle differentiation. Cutaneous RMSs are exceedingly rare, and in most cases, they represent metastatic disease or the dermal involvement by a tumor arising in the underlying soft tissues. We herein report the case of a 41-year-old man who developed a cutaneous swelling of the right nasal orbital angle. An initial incisional biopsy showed cytokeratin-positive atypical spindle cells forming long and intersecting fascicles, thus the case was diagnosed as carcinosarcoma. In the subsequent excisional biopsy, the skeletal myogenic differentiation of the tumor cells infiltrating the dermis and subcutis was demonstrated by morphology (presence of rhabdomyoblasts), immunohistochemistry (positivity for desmin, myogenin, myoglobin, and actins), and electron microscopy (evidence of rudimentary sarcomeric structures). A final diagnosis of primary cutaneous RMS was made. The patient was subjected to postoperative radiation and chemotherapy, but after 4 months, the patient developed a tumor recurrence followed by distant metastases and death. Review of the literature reveals that RMSs of the skin are often underrecognized and display peculiar clinical features in comparison with their more common soft tissue counterpart.

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Section: Discussionmentioning

confidence: 99%

Rhabdomyosarcoma of the Skin Resembling Carcinosarcoma: Report of a Case and Literature Review

Scatena¹,

Massi²,

Franchi³

et al. 2012

The American Journal of Dermatopathology

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“…Clinically, the manifestations of RMS may vary from a small cutaneous nodule on the face to an extensive fast-growing facial swelling, which may be painless or occasionally associated with pain, trismus, paresthesia, facial palsy, and nasal discharge. [ 3 ]…”

Section: Introductionmentioning

confidence: 99%

Rhabdomyosarcoma in a pediatric patient: A rare case report

Shrutha

Vinit

2015

Contemp Clin Dent

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Rhabdomyosarcoma (RMS), a tumor of skeletal muscle origin, is the second most common soft tissue sarcoma encountered in childhood after osteosarcoma. The common sites of occurrence are the head and neck region, genitourinary tract, retroperitoneum, and to a lesser extent, the extremities. Site predilections in the oral cavity are a soft palate, maxillary sinus and alveolus, posterior mandibular region, cheek and lip, and possibly tongue. RMS is a highly malignant tumor with extensive local invasions and early hemorrhagic and lymphatic dissemination. Despite aggressive approaches incorporating surgery, dose-intensive combination chemotherapy, and radiation therapy, the outcome for patients with metastatic disease remains poor. Here, we report a case of oral RMS in a 1-year-old child and describe the clinical, radiological, histopathological, and immunohistochemical findings.

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“…The etiology is uncertain, however, the origin is presumed to be an overgrowth of the sarcomatous component of teratoma. Primary intratesticular Rhabdomyosarcoma is very rare and accounts for 10% of testicular tumor in children (3)(4)(5). .…”

Section: Introductionmentioning

confidence: 99%

Primary Intratesticular Rhabdomyosarcoma - A Rare Case Report

Usmani¹,

Tandon²,

Rizvi³

et al. 2017

EJMR

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Rhabdomyosarcoma is one of most frequent soft tissue sarcoma of skeletal muscle origin. It occurs predominantly in Head& Neck, Genitourinary tract and extremities. The majority of cases of rhabdomyosarcoma in the genitourinary tract occurs in the bladder and paratesticular organs Primary intratesticular Rhabdomyosarcoma is very rare, have aggressive growth pattern. A 15 years old male presented with painless right testicular swelling who underwent high inguinal orchidectomy and left testis appeared normal. Complete blood count , Serum alpha-fetoprotein (1ng/ml) and Beta Human chorionic gonadotropin(<2.39) are with in normal limits.X-ray{chest}reveals multiple variable sized nodules in bilateral lungs with right hilar lymphadenopathy.?Metastasis.HR-USG (scrotum) reveals ill-defined lobulated , heterogeneously hypoechoic, soft tissue mass with increased internal vascularity in the right scrotal region with multiple enlarged lymphnodes suggestive of neoplastic etiology. On histopathology diagnosis of rhabdomyosarcoma-Right testis was made., have aggressive growth pattern. The optimal management of paratesticular rhabdomyosarcoma remains unclear because of the rarity of the disease in adults.Radical orchidectomy with negative surgical margins followed by RPLND and chemotherapy is the recommended treatment. For the control of local recurrence and metastasis radiotherapy is recommended.The purpose of this article is to report a case of 15 years old male with primary intratesticular rhabdomyasarcoma which is very rare and our best knowledge few cases have been reported in the literature till now.

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Rhabdomyosarcoma presenting as a cutaneous nodule

Cited by 13 publications

References 0 publications

Rhabdomyosarcoma of the Skin Resembling Carcinosarcoma: Report of a Case and Literature Review

Rhabdomyosarcoma of the Skin Resembling Carcinosarcoma: Report of a Case and Literature Review

Rhabdomyosarcoma in a pediatric patient: A rare case report

Primary Intratesticular Rhabdomyosarcoma - A Rare Case Report

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