Rhabdomyosarcoma - an Epidemiological and Histopathologic Study of 277 Cases from a Major Tertiary Care Center in Karachi, Pakistan

Identifying barriers to treatment of childhood rhabdomyosarcoma in resource‐limited settings: A literature review

“…Similar to UMIC reports, combination chemotherapy was also used in all series, based on either North American or European risk‐adapted protocols (see Table ). Diagnostic and local control modalities were available in the majority of reported series, with the exceptions of reports from Guatemala, Nigeria, and Morocco, where major deficiencies in diagnostic modalities and in local control modalities were brought up as limitations by the authors …”

“…Outcomes varied across series. Importantly, abandonment rates were very high in eight reports from six countries, [15][16][17][18][19][20][21][22] with up to 18% of patients' caregivers refusing and up to 73% abandoning treatment at various phases of therapy. Outcomes were dismal with no survivors in another report from Karachi.…”

Abdominopelvic tumor mass in adolescent – a case report

“…Rabdomiosarcomas with pelvic site are rare. A large study, including children and adults, reported a frequency of pelvic sites at 3.3% (14). As RMS is derived from primitive mesenchymal stem cells directed towards myogenesis, it can arise in a variety of anatomic sites throughout the body (15).…”

“…A study of 25 children with rhabdomyosarcoma previously performed at the same hospital found in 20 cases the embryo type (17). A larger study of 277 patients of all ages reported an 87.4% embryotype, 9.4% alveolar and pleomorphic type in 1.8% of cases (14).Currently, multimodality treatment that includes chemotherapy, surgery with or without radiation therapy, had become the standard care for RMS (6). Survival rates for adolescents and adults with RMS, on the other hand, are significantly worse compared to younger children (range 21%-56%) (18,19).…”

Rhabdomyosarcoma mimicking as pleural effusion

“…observed over 80% cases of ARMS occurred in the first three decades of life. [ 4 ] Accurate and quick diagnosis are often difficult due to the heterogeneity of these tumors and a lack of strong genetic markers of the disease. RMSs are known to occur at any site in the body but are more commonly seen in head, neck region, genitourinary tract, or extremities.…”