Rewarming Patterns in Hand Fracture Patients With and Without Cold Intolerance

Smits, Ernst; Nijhuis, T.; Huygen, Frank; Selles, Ruud W.; Hovius, Steven E.R.; Niehof, Sjoerd P.

doi:10.1016/j.jhsa.2010.12.034

Cited by 22 publications

(18 citation statements)

References 39 publications

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“…This type of allodynia has been described in animal pain models (45)(46)(47) and also in patients after hand fracture (48,49). However, the underlying mechanism(s) of cold allodynia in our model remains unclear.…”

Section: Discussionmentioning

confidence: 66%

Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels

Zhang

Barde

Yang

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Pain is a critical component hindering recovery and regaining of function after surgery, particularly in the elderly. Understanding the role of pain signaling after surgery may lead to novel interventions for common complications such as delirium and postoperative cognitive dysfunction. Using a model of tibial fracture with intramedullary pinning in male mice, associated with cognitive deficits, we characterized the effects on the primary somatosensory system. Here we show that tibial fracture with pinning triggers cold allodynia and up-regulates nerve injury and inflammatory markers in dorsal root ganglia (DRGs) and spinal cord up to 2 wk after intervention. At 72 h after surgery, there is an increase in activating transcription factor 3 (ATF3), the neuropeptides galanin and neuropeptide Y (NPY), brain-derived neurotrophic factor (BDNF), as well as neuroinflammatory markers including ionized calcium-binding adaptor molecule 1 (Iba1), glial fibrillary acidic protein (GFAP), and the fractalkine receptor CX3CR1 in DRGs. Using an established model of complete transection of the sciatic nerve for comparison, we observed similar but more pronounced changes in these markers. However, protein levels of BDNF remained elevated for a longer period after fracture. In the hippocampus, BDNF protein levels were increased, yet there were no changes in Bdnf mRNA in the parent granule cell bodies. Further, c-Fos was down-regulated in the hippocampus, together with a reduction in neurogenesis in the subgranular zone. Taken together, our results suggest that attenuated BDNF release and signaling in the dentate gyrus may account for cognitive and mental deficits sometimes observed after surgery.postoperative pain | nerve injury | memory | delirium | neurogenesis

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Section: Discussionmentioning

confidence: 66%

Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels

Zhang

Barde

Yang

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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“…ABCI of the hand and fingers is a significant problem after injuries to the upper limb, [4][5][6]12,13 most frequently described after digital injuries and digital replantation. [7][8][9][10][11][12][13][14] In contrast to several reports on ABCI after hand injuries, [4][5][6][7][27][28][29] which correlated ABCI development to the patency of repaired digital arteries, 12,20 ABCI after repair of major arm arteries (ie, subclavian, axillary, brachial, radial, and ulnar arteries) was not analyzed in large series up to now. In 1979, Gelberman et al 14 studied hemodynamic alterations and symptoms of cold intolerance after single forearm arterial injuries with (n ϭ 13) and without (n ϭ 7) concomitant neurological lesions.…”

Section: Discussionmentioning

confidence: 89%

“…For testing of ABCI, we used a free-accessible standardized questionnaire, the CISS questionnaire, which was first published by Irwin et al 3 and modified by Ruijs et al 4 in 2006. The CISS form was frequently used recently to assess cold-related problems, 5,6,28,29,35 and ABCI was defined as a CISS score over 30. 4 The CISS form represents a clear and simple questionnaire which is based on six questions asking for symptoms, frequency and relief of symptoms, individual adaption, and problems during daily activities.…”

Section: Discussionmentioning

confidence: 99%

Incidence and predisposing factors of cold intolerance after arterial repair in upper extremity injuries

Klocker

Peter

Pellegrini

et al. 2012

Journal of Vascular Surgery

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“…In a population-based case-control study, the condition was associated to frostbite, nerve injury, rheumatic disease, migraines, and vascular disease, while a high body mass index (≥25 kg/m 2 ) appeared protective [7]. The pathophysiology behind CS is obscure, but hypotheses regarding vascular and neurosensory mechanisms have been presented [8][9][10]. The diagnosis of CS is based on the symptoms reported by the individual, and questionnaires such as the Cold Intolerance Symptom Severity (CISS) score [11].…”

Section: Cold Sensitivitymentioning

confidence: 99%

Manifestations of cold sensitivity – a case series

Stjernbrandt

Björ

Pettersson

et al. 2020

International Journal of Circumpolar Health

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Objectives: To characterise cold sensitivity using a semi-structured interview, physical examination, thermal quantitative sensory testing (QST), and laser speckle contrast analysis (LASCA). Methods: Eight women and four men, ages 22-74, with cold sensitivity were interviewed and examined by an occupational physician. Thermal perception thresholds were established using QST, on the pulp of the index and little finger of the most affected hand. Skin perfusion in the dorsum of the hand was measured using LASCA, at baseline, after two-minute 12°C water immersion, and during rewarming. Results: The physical examination yielded few findings indicative of vascular or neurosensory pathology. One subject (8%) had impaired thermal perception thresholds. LASCA at baseline showed absent proximal-distal perfusion gradients in six subjects (50%), and a dyshomogeneous perfusion pattern in five (42%). Perfusion on a group level was virtually unchanged by cold stress testing (median 52.5 PU; IQR 9.0 before versus 51.3 PU; IQR 27.2 afterwards). Conclusions: Physical examination and thermal QST offered little aid in diagnosing cold sensitivity, which challenges the neurosensory pathophysiological hypothesis. LASCA indicated disturbances in microvascular regulation and could prove a useful tool in future studies on cold sensitivity.

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Rewarming Patterns in Hand Fracture Patients With and Without Cold Intolerance

Cited by 22 publications

References 39 publications

Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels

Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels

Incidence and predisposing factors of cold intolerance after arterial repair in upper extremity injuries

Manifestations of cold sensitivity – a case series

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