Objective
We evaluated the effectiveness of short-term cash and food assistance
to improve adherence to antiretroviral therapy (ART) and retention in care
among people living with HIV (PLHIV) in Tanzania.
Methods
At three clinics, 805 participants were randomized to three groups in
a 3:3:1 ratio, stratified by site: nutrition assessment and counseling (NAC)
plus cash transfers (~$11/month, n=347), NAC plus food baskets
(n=345), and NAC-only (comparison group, n=113,
clinicaltrials.gov NCT01957917). Eligible PLHIV were:
≥18 years, initiated ART ≤90 days prior, and food insecure.
Cash or food was provided for ≤6 consecutive months, conditional on
visit attendance. The primary outcome was medication possession ratio (MPR)
≥95% at 6 months. Secondary outcomes were appointment
attendance and loss to follow-up (LTFU) at 6 and 12 months.
Results
The primary intent-to-treat analysis included 800 participants.
Achievement of MPR≥95% at 6 months was higher in the
NAC+cash group compared to NAC-only (85.0% vs.
63.4%), a 21.6 percentage point difference (95% confidence
interval (CI): 9.8, 33.4, p<0.01). MPR≥95% was also
significantly higher in the NAC+food group versus NAC-only
(difference=15.8, 95% CI: 3.8, 27.9, p<0.01). When
directly compared, MPR≥95% was similar in the
NAC+cash and NAC+food groups (difference=5.7,
95% CI: −1.2, 12.7, p=0.15). Compared to NAC-only,
appointment attendance and LTFU were significantly higher in both the
NAC+cash and NAC+food groups at 6 months. At 12 months, the
effect of NAC+cash, but not NAC+food, on
MPR≥95% and retention was sustained.
Conclusions
Short-term conditional cash and food assistance improves ART
possession and appointment attendance and reduces LTFU among food-insecure
ART initiates in Tanzania.