Cell Reports volume 3, issue 5, P1539-1552 2013 DOI: 10.1016/j.celrep.2013.04.025 View full text
André Görgens, Stefan Radtke, Michael Möllmann, Michael Cross, Jan Dürig, Peter A. Horn, Bernd Giebel

Abstract: The classical model of hematopoiesis predicts a dichotomous lineage restriction of multipotent hematopoietic progenitors (MPPs) into common lymphoid progenitors (CLPs) and common myeloid progenitors (CMPs). However, this idea has been challenged by the identification of lymphoid progenitors retaining partial myeloid potential (e.g., LMPPs), implying that granulocytes can arise within both the classical lymphoid and the myeloid branches. Here, we resolve this issue by using cell-surface CD133 expression to disc…

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