2020
DOI: 10.1111/hel.12743
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Abstract: This review summarizes important studies regarding Helicobacter pylori therapy published from April 2019 to April 2020. The main themes that emerge involve studies assessing antibiotic resistance, and there is also growing momentum behind the utility of vonoprazan as an alternative to proton pump inhibitor (PPI) therapy and also bismuth‐based regimens as a first‐line regimen. Antibiotic resistance is rising wherever it is being assessed, and clarithromycin resistance in particular has reached a point where it … Show more

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Cited by 37 publications
(17 citation statements)
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“…Furthermore, CagA suppresses the apoptotic activity of VacA and activates the signaling pathway of the factor NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), allowing the subsequent overexpression of anti-apoptotic agents, interleukin (IL)-8, and defensins (hβDs). H. pylori causes apoptosis accompanied by increased expression of the pro-apoptotic multi-domain proteins Bax (Bcl-2-associated X protein) and Bak proteins that favor apoptosis, suggesting that Bax and Bak may be important mediators of gastric epithelial cells of apoptosis [68][69][70][71].…”
Section: Figurementioning
confidence: 99%
“…Furthermore, CagA suppresses the apoptotic activity of VacA and activates the signaling pathway of the factor NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), allowing the subsequent overexpression of anti-apoptotic agents, interleukin (IL)-8, and defensins (hβDs). H. pylori causes apoptosis accompanied by increased expression of the pro-apoptotic multi-domain proteins Bax (Bcl-2-associated X protein) and Bak proteins that favor apoptosis, suggesting that Bax and Bak may be important mediators of gastric epithelial cells of apoptosis [68][69][70][71].…”
Section: Figurementioning
confidence: 99%
“…In many developing countries it infects about 80% of the population and in developed countries it infects about 30% [2,3]. H. pylori plays an important role in the pathogenesis of chronic gastritis, peptic ulcer diseases, gastric carcinomas, and gastric marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue type [4,5,6,7].…”
Section: Introductionmentioning
confidence: 99%
“…If untreated or not correctly cured, this nasty pathogen induces gastric inflammatory responses developing into pathological conditions (gastritis, peptic ulcer, gastric cancer, mucosa-associated lymphoid tissue) during its adaptation and replication within the stomach environment. In addition, the current pharmacological therapy is hampered by the development of resistance mechanisms, making the available arsenal the last-resort medicines [ 15 ].…”
Section: Introductionmentioning
confidence: 99%