Review on production, characterization and applications of microbial levan

Ryali, Srikanth; Reddy, Chinta H.S.S. Sundhar; Siddartha, Gudimalla; Ramaiah, M. Janaki; Uppuluri, Kiran Babu

doi:10.1016/j.carbpol.2014.12.003

Cited by 223 publications

(161 citation statements)

References 82 publications

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“…In fact, the most interesting feature of levansucrase is its distinctive ability to produce levan from sucrose (Srikanth et al 2015). A great deal of research shows that levan has promising physiological effects and exhibits great potential in the food and pharmaceutical industries.…”

Section: Levan Biosynthesismentioning

confidence: 99%

“…Many levan-producing strains have been isolated, including Acetobacterxylinum NCI 1005 (Tajima et al 1997), B. subtilis (Natto) Takahashi (Shih et al 2005), Bacillus polymyxa NRRL B-18475 (Han and Clarke 1990;Han and Watson 1992), and Microbacterium laevaniformans KCTC 9732 (Bae et al 2008). Levansucrase is the key enzyme for producing microbial levan from sucrose (Srikanth et al 2015), and sucrose supplementation usually induces levansucrase expression during fermentation.…”

Section: Levan Biosynthesismentioning

confidence: 99%

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Recent novel applications of levansucrases

Zhang

et al. 2015

Appl Microbiol Biotechnol

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Levansucrase catalyzes three distinct reactions depending on the fructosyl acceptor molecule, including polymerization, transfructosylation, and hydrolysis. As a key biocatalyst in the synthesis of levan and levan-type fructooligosaccharides, levansucrase has been widely and intensively studied. Due to the promising physiological effects of levan and levan-type fructooligosaccharides, they exhibit great potential in food and pharmaceutical industries. Another important point that attracts much attention is the wide substrate specificity of levansucrase toward monosaccharides, disaccharides, and aromatic and alkyl alcohols, producing diverse sucrose analogues, hetero-oligosaccharides (especially lactosucrose), and interesting fructosides. The present article summarizes and discusses the recent applications of microbial levansucrase in detail.

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Section: Levan Biosynthesismentioning

confidence: 99%

Section: Levan Biosynthesismentioning

confidence: 99%

Recent novel applications of levansucrases

Zhang

et al. 2015

Appl Microbiol Biotechnol

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“…The propensity of exopolysaccharides to self-assemble arises from attractive dispersion forces between alkyl side chains and core of the nanoparticles. Amphiphilic nature of levans results in the formation of self-assembled nanoparticles from water (Srikanth et al, 2014). Selenium, iron or cobalt encapsulated in levan nanoparticles have been produced with reduced toxicity and protective effect on human intestinal Caco 2 cells (Bondarenko et al, 2015).…”

Section: Exploring Pharmaceutical Opportunities Of Bacterial Exopolysmentioning

confidence: 99%

Rheological Behavior and Pharmaceutical Applications of Bacterial Exopolysaccharides

2017

J App Pharm Sci

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Over the last few decades, numerous bacterial exopolysaccharides have been extensively studied for their composition, structure, biosynthesis and functional properties, owing to their unique properties over traditional plant-derived gums and synthetic polysaccharides. They have been employed in food processing industries as rheology modifiers, gelling agents, in oil drilling and cement industries. But their full-fledged commercialization is yet to be achieved and their scope and possibilities in pharmaceutical field and optimized drug delivery are yet to be explored. The present review outlines, critically evaluates and summarizes the research outcomes on structure, solubility, solution behavior, rheological characterization, gelation mechanism and potential industrial and pharmaceutical applications of curdlan, polysaccharide 13140, Fucopol, levan, sphingans, succinoglycan and several other bacterial exopolysaccharides in their native form and also their derivatives. It also aims to identify and propose potential drug delivery systems where gelling and non gel-forming exopolysaccharides can be utilized successfully for development of stable, acceptable and effective dosage form.

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“…pH (Gibson and Roberfroid, 1995;El-Nagar et al, 2002;Akin et al, 2007;Adebola et al, 2014), (Kang et al, 2009, Srikanth et al, 2015. , …”

Section: (Prebiotics)mentioning

confidence: 99%

“…( -glucans) (vitamin) (Sun et al, 2008;Gu et al, 2010;Zhao et al, 2010;Ma et al, 2013;Wang et al, 2014;Srikanth et al, 2015). , (Xia et al, 2012;Shi et al, 2013;Choi, 2014).…”

Section: 홍해삼 내 다당류 분석unclassified

Growth and Physiological Effects of Immunity Feed Additives on the Juvenile Red Sea Cucumber Stichopus japonicus

Namgung¹,

Ahn²,

Yeo³

2015

Korean Journal of Fisheries and Aquatic Sciences

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The juvenile red variant of the sea cucumber Stichopus japonicus is distributed worldwide. It is a valuable food source in Korea, China, and Japan. Major issues in farming the juvenile red variant sea cucumber include growth rates and disease resistance. In recent years, studies have focused on feed additives to enhance immune system and health. In this study, we used a common diet (CD), a nutritional diet (ND; mixed nutritional supplements), and an immunity diet (ID; mixed probiotics, spirulina, and levan) and compared the growth rates and immunity of juvenile red variant sea cucumbers fed the experimental diets for 12 weeks. The growth and survival rates in the ID group were significantly increased (P>0.05). This suggests that the feed additives positively influenced immunity and growth in the ID group. However, the immune activity was exhibit a stabilizing effect, and further investigation of immune effects is required.

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Review on production, characterization and applications of microbial levan

Cited by 223 publications

References 82 publications

Recent novel applications of levansucrases

Recent novel applications of levansucrases

Rheological Behavior and Pharmaceutical Applications of Bacterial Exopolysaccharides

Growth and Physiological Effects of Immunity Feed Additives on the Juvenile Red Sea Cucumber Stichopus japonicus

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