Review of the literature on benzene exposure and leukemia subtypes

Schnatter, A. Robert; Rosamilia, Kim; Wojcik, Nancy C.

doi:10.1016/j.cbi.2005.03.039

Cited by 125 publications

(78 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Few studies have shown an association between risk of leukemia and exposure to lower concentrations of benzene in the workplace (40). Yin reported that total WBC reduced similarly in workers exposed to benzene (41).…”

Section: Discussionmentioning

confidence: 99%

Hematologic Evaluation of Painting Hall Workers in an Automobile Manufacturing Company

et al. 2017

View full text Add to dashboard Cite

Background: Exposure to benzene causes several adverse effects, including decreased number of erythrocytes, leucocytes, and red blood cells, and results in aplastic anemia. The aim of this study was to investigate hematological changes due to benzene exposure in painting workers. Methods: This study was conducted on benzene-exposed and nonexposed workers in Tehran, Iran. The study sample included 40 painters exposed to different levels of benzene and 40 unexposed controls in an automobile manufacturing company. Sampling was carried out with an active pump sampler, using the NIOSH method 1501. Varian C-3800 gas chromatography-flame ionization detector (GC-FID) was used for the analysis of 40 benzene samples. Blood samples from 80 workers were collected from both the case and control groups. Hematological indices were analyzed for red blood cell, white blood cell, hematocrit, hemoglobin, platelet, and white cell differential count.

show abstract

Section: Discussionmentioning

confidence: 99%

Hematologic Evaluation of Painting Hall Workers in an Automobile Manufacturing Company

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Benzene is known to depress bone marrow and to induce leukemia in humans and is a multisite carcinogen in rodents (1)(2)(3). It is a major industrial chemical, air pollutant and tobacco smoke constituent (4,5).…”

Section: Introductionmentioning

confidence: 99%

The role of nitric oxide on DNA damage induced by benzene metabolites

Melikian

Chen

et al. 2008

Oncol Rep

View full text Add to dashboard Cite

Benzene, a tobacco constituent, is a leukemogen in humans and a carcinogen in rodents. Several benzene metabolites generate superoxide anion (O 2 •− ) and induce nitric oxide synthase in the bone marrow of mice. We hypothesized that the reaction of nitric oxide ( • NO) with O 2•− leads to the formation of peroxynitrite as an intermediate during benzene metabolism. This hypothesis was supported by demonstrating that the exposure of mice to benzene produced nitrated metabolites and enhanced the levels of protein-bound 3-nitrotyrosine in the bone marrow of mice in vivo. In the current study, we investigated the influence of nitric oxide, generated from sodium 1-(N,Ndiethylamino)diazen-1-ium-1,2-diolate, on DNA strand breaks induced by each single or binary benzene metabolite at different doses and compared the levels of the DNA damage induced by each benzene metabolite in the presence of nitric oxide with the levels of DNA strand breaks induced by peroxynitrite at similar doses in vitro. We found that among benzene metabolites only 1,2,4-trihydroxybenzene (BT) can induce significant DNA damage in the absence of nitric oxide.

show abstract

“…Benzene is a human clastogen: chronic exposure leads to consistent structural and numerical chromosomal aberrations in lymphocytes and bone marrow cells which may be recorded for at least 5 years after cessation of (occupational) exposure [15][16][17][18][19][20][21][22]. Benzene diffuses across the placenta and is considered to be fetotoxic.…”

Section: Discussionmentioning

confidence: 99%

Chemical composition of surgical smoke formed in the abdominal cavity during laparoscopic cholecystectomy – Assessment of the risk to the patient

Dobrogowski¹,

Wesołowski²,

Kucharska³

et al. 2014

International Journal of Occupational Medicine and Environmental Health

View full text Add to dashboard Cite

Objectives: The aim of this study was to assess the exposure of patients to organic substances produced and identified in surgical smoke formed in the abdominal cavity during laparoscopic cholecystectomy. Material and Methods: Identification of these substances in surgical smoke was performed by the use of gas chromatography-mass spectrometry (GC-MS) with selective ion monitoring (SIM). The selected biomarkers of exposure to surgical smoke included benzene, toluene, ethylbenzene and xylene. Their concentrations in the urine samples collected from each patient before and after the surgery were determined by SPME-GC/MS. Results: Qualitative analysis of the smoke produced during laparoscopic procedures revealed the presence of a wide variety of potentially toxic chemicals such as benzene, toluene, xylene, dioxins and other substances. The average concentrations of benzene and toluene in the urine of the patients who underwent laparoscopic cholecystectomy, in contrast to the other determined compounds, were significantly higher after the surgery than before it, which indicates that they were absorbed. Conclusions: The source of the compounds produced in the abdominal cavity during the surgery is tissue pyrolysis in the presence of carbon dioxide atmosphere. All patients undergoing laparoscopic procedures are at risk of absorbing and excreting smoke by-products. Exposure of the patient to emerging chemical compounds is usually a one-time and short-term incident, yet concentrations of benzene and toluene found in the urine were significantly higher after the surgery than before it.

show abstract

Review of the literature on benzene exposure and leukemia subtypes

Cited by 125 publications

References 31 publications

Hematologic Evaluation of Painting Hall Workers in an Automobile Manufacturing Company

Hematologic Evaluation of Painting Hall Workers in an Automobile Manufacturing Company

The role of nitric oxide on DNA damage induced by benzene metabolites

Chemical composition of surgical smoke formed in the abdominal cavity during laparoscopic cholecystectomy – Assessment of the risk to the patient

Contact Info

Product

Resources

About