Review of the Clinical Characteristics of Coronavirus Disease 2019 (COVID-19)

Jiang, Fang; Deng, Liehua; Zhang, Liangqing; Cai, Yin; Cheung, Chi Wai; Xia, Zhengyuan

doi:10.1007/s11606-020-05762-w

Cited by 1,237 publications

(1,257 citation statements)

References 20 publications

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“…Common symptoms at onset of COVID-19 were fever, dry cough, myalgia, fatigue etc. 6,16 In our study, we observed that besides fever and cough, dyspnea (54.5%) presented early in most nonsurvivors with confirmed COVID-19, similar finding has also been observed in critically ill patients reported by Yang etc. 17 Recent publication suggested the median time from onset of symptoms to hospital admission of deceased patients was 10.0 (IQR, 7.0-13.0) days, which tended to be longer than that of recovered patients (9.0 (6.0-12.0) days).…”

Section: Bysupporting

confidence: 89%

Clinical characteristics of 101 COVID-19 nonsurvivors in Wuhan, China: a retrospective study

Shi

Zhao

et al. 2020

Preprint

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Background The outbreak of COVID-19 has aroused global concerns. We aimed to describe the clinical characteristics of COVID-19 nonsurvivors and analyze possible causes for the rapid disease progress to death. Methods Patients with confirmed COVID-19 died in Renmin Hospital of Wuhan University before February 15, 2020, were identified. We obtained epidemiological, demographic, and clinical data from electronic medical records. Results Among 101 nonsurvivors, the median age was 71.0 years (IQR, 59.0-80.0), 59.4% were male, 79.2% had one or more comorbidities including hypertension (58.4%), cardiovascular disease (22.8%), diabetes (20.8%) etc. The most common symptoms were fever (76.2%), cough (58.4%) and dyspnea (54.5%). Respiratory failure (99.0%), acute cardiac injury (52.5%), sepsis (40.6%) and acute kidney injury (23.8%) were most common complications. Compared with patients died after 3 days of admission, patients died within 3 days of admission had significantly higher white blood cell count (10.8 vs 6.7*109/L, P=0.001) and neutrophil count (8.9 vs 5.5*109/L, P=0.001), longer prothrombin time (13.2 vs 12.5 s, P=0.040), higher D-dimer concentration (7.64 vs 2.82, P=0.040), higher lactate level (2.9 vs 2.2 mmol/L, P=0.042), lower oxygen saturation (85.0% vs 91.0%, P=0.008), and were more likely to suffer sepsis (52.1% vs 30.2%, P=0.025). Conclusions Older patients with underlying comorbidities suffering COVID-19 were at high risk of death. Respiratory failure, acute cardiac injury and acute kidney injury played crucial roles in the death of COVID-19 patients. Early development of sepsis was associated with the rapid disease progress to death.

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Section: Bysupporting

confidence: 89%

Clinical characteristics of 101 COVID-19 nonsurvivors in Wuhan, China: a retrospective study

Shi

Zhao

et al. 2020

Preprint

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“…oseltamivir, abidol, and lopinavir/ritonavir. 40,41 These antiviral drugs can induce liver injury as well. A clinical trial of lopinavir/ritonavir or abidol for treatment of COVID-19 from Shanghai showed that two cases of each group occurred liver injury among twohundred and sixty-two patients.…”

Section: Stress and Systemic Inflammation-related Liver Injury In Covmentioning

confidence: 99%

Characteristics and Mechanism of Liver Injury in 2019 Coronavirus Disease

Li¹,

Fan²

2020

Journal of Clinical and Translational Hepatology

270

286

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An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (2019 coronavirus disease, COVID-19) since December 2019, from Wuhan, China, has been posing a significant threat to global human health. The clinical features and outcomes of Chinese patients with COVID-19 have been widely reported. Increasing evidence has witnessed the frequent incident liver injury in COVID-19 patients, and it is often manifested as transient elevation of serum aminotransferases; however, the patients seldom have liver failure and obvious intrahepatic cholestasis, unless preexisting advanced liver disease was present. The underlying mechanisms of liver injury in cases of COVID-19 might include psychological stress, systemic inflammation response, drug toxicity, and progression of pre-existing liver diseases. However, there is insufficient evidence for SARS-CoV-2 infected hepatocytes or virus-related liver injury in COVID-19 at present. The clinical, pathological and laboratory characteristics as well as underlying pathophysiology and etiology of liver injury in COVID-19 remain largely unclear. In this review, we highlight these important issues based on the recent developments in the field, for optimizing the management and treatment of liver injury in Chinese patients with COVID-19. Citation of this article: Li J, Fan JG. Characteristics and mechanism of liver injury in 2019 coronavirus disease.

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“…By March 2020 the virus has spread globally and was declared as pandemic by the World Health Organization (World Health Organization, 2020). COVID-19 is an acute respiratory disease which may lead to pneumonia with symptoms such as fever, cough and dyspnea (Jiang et al, 2020) and has an approximate fatality rate of 2-3% (Rodriguez-Morales et al, 2020). As of March 19, 2020, there have Science of the Total Environment 726 (2020) 138605 E-mail address: yaron.ogen@geo.uni-halle.de.…”

Section: Introductionmentioning

confidence: 99%

Assessing nitrogen dioxide (NO2) levels as a contributing factor to coronavirus (COVID-19) fatality

Ogen

2020

Science of The Total Environment

755

649

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Nitrogen dioxide (NO 2 ) is an ambient trace-gas result of both natural and anthropogenic processes. Long-term exposure to NO 2 may cause a wide spectrum of severe health problems such as hypertension, diabetes, heart and cardiovascular diseases and even death. The objective of this study is to examine the relationship between long-term exposure to NO 2 and coronavirus fatality. The Sentinel-5P is used for mapping the tropospheric NO 2 distribution and the NCEP/NCAR reanalysis for evaluating the atmospheric capability to disperse the pollution. The spatial analysis has been conducted on a regional scale and combined with the number of death cases taken from 66 administrative regions in Italy, Spain, France and Germany. Results show that out of the 4443 fatality cases, 3487 (78%) were in five regions located in north Italy and central Spain. Additionally, the same five regions show the highest NO 2 concentrations combined with downwards airflow which prevent an efficient dispersion of air pollution. These results indicate that the long-term exposure to this pollutant may be one of the most important contributors to fatality caused by the COVID-19 virus in these regions and maybe across the whole world.

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Review of the Clinical Characteristics of Coronavirus Disease 2019 (COVID-19)

Cited by 1,237 publications

References 20 publications

Clinical characteristics of 101 COVID-19 nonsurvivors in Wuhan, China: a retrospective study

Clinical characteristics of 101 COVID-19 nonsurvivors in Wuhan, China: a retrospective study

Characteristics and Mechanism of Liver Injury in 2019 Coronavirus Disease

Assessing nitrogen dioxide (NO2) levels as a contributing factor to coronavirus (COVID-19) fatality

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