Review of Recent Patents on Foldable Ventricular Assist Devices

Hsu, Po-Lin; McIntyre, Madeleine; Kuetting, Maximilian; Parker, Jack; Egger, Christina; Autschbach, Rüdiger; Schmitz‐Rode, Thomas; Steinseifer, Ulrich

doi:10.2174/1874764711205030208

BIOMENG

2012

DOI: 10.2174/1874764711205030208

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Review of Recent Patents on Foldable Ventricular Assist Devices

Po-Lin Hsu

Madeleine McIntyre²,

Maximilian Kuetting³

et al.

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Cited by 4 publications

(2 citation statements)

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“…Mechanically folded structures adapt joints and links to facilitate the folding process, whereas utilization of elastic materials allows the structure to be bent or twisted without permanent deformation. Hybrid devices have been defined as the systems that combine the use of structural features and inherent material properties for folding (8).…”

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confidence: 99%

“…Nevertheless, a blade should always be optimized for sufficient output and optimal hemodynamic performance. This optimization can lead to a highly curved blade geometry that makes it challenging to fold without compromising the hydraulic efficiency (7,8). Once a blade design for a foldable device is confirmed, it is then critical to investigate its foldability by evaluating the resulting stress and strain during operating and folded states.…”

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Design Method of a Foldable Ventricular Assist Device for Minimally Invasive Implantation

et al. 2013

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To date, ventricular assist devices (VADs) have become accepted as a therapeutic solution for end-stage heart failure patients when a donor heart is not available. Newer generation VADs allow for a significant reduction in size and an improvement in reliability. However, the invasive implantation still limits this technology to critically ill patients. Recently, expandable/deployable devices have been investigated as a potential solution for minimally invasive insertion. Such a device can be inserted percutaneously via peripheral vessels in a collapsed form and operated in an expanded form at the desired location. A common structure of such foldable pumps comprises a memory alloy skeleton covered by flexible polyurethane material. The material properties allow elastic deformation to achieve the folded position and withstand the hydrodynamic forces during operation; however, determining the optimal geometry for such a structure is a complex challenge. The numerical finite element method (FEM) is widely used and provides accurate structural analysis, but computation time is considerably high during the initial design stage where various geometries need to be examined. This article details a simplified two-dimensional analytical method to estimate the mechanical stress and deformation of memory alloy skeletons. The method was applied in design examples including two popular types of blade skeletons of a foldable VAD. Furthermore, three force distributions were simulated to evaluate the strength of the structures under different loading conditions experienced during pump operation. The results were verified with FEM simulations. The proposed two-dimensional method gives a close stress and deformation estimation compared with three-dimensional FEM simulations. The results confirm the feasibility of such a simplified analytical approach to reveal priorities for structural optimization before time-consuming FEM simulations, providing an effective tool in the initial structural design stage of foldable minimally invasive VADs.

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Design Method of a Foldable Ventricular Assist Device for Minimally Invasive Implantation

et al. 2013

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A brief review of bio-tribology in cardiovascular devices

Xie

Leng

Jing

et al. 2015

Biosurface and Biotribology

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Intracardiac Turbines Suitable for Catheter-Based Implantation—An Approach to Power Battery and Leadless Cardiac Pacemakers?

Haeberlin

Rösch

Tholl

et al. 2020

IEEE Trans. Biomed. Eng.

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Review of Recent Patents on Foldable Ventricular Assist Devices

Cited by 4 publications

References 20 publications

Design Method of a Foldable Ventricular Assist Device for Minimally Invasive Implantation

Design Method of a Foldable Ventricular Assist Device for Minimally Invasive Implantation

A brief review of bio-tribology in cardiovascular devices

Intracardiac Turbines Suitable for Catheter-Based Implantation—An Approach to Power Battery and Leadless Cardiac Pacemakers?

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