Review of animal models designed to predict the potential allergenicity of novel proteins in genetically modified crops

Ladics, Gregory S.; Knippels, L.M.J.; Penninks, André; Bannon, Gary A.; Goodman, Richard E.; Hérouet-Guicheney, Corinne

doi:10.1016/j.yrtph.2009.09.018

Cited by 62 publications

(67 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly to other animal models, sheep were sensitized by multiple subcutaneous injections of crude peanut extract and ovalbumin. As outcome the investigators were able to show the presence of Ara h 1-and Ara h 2-specific serum IgE in 100% and 80%, respectively, of the sensitized sheep and a positive intradermal test in 80% of the high-IgE producing sheep [111].…”

Section: Other Large Animal Models For Food Allergymentioning

confidence: 90%

“…The most commonly used strain is the brown Norway able to produce allergen specific IgE after oral sensitization and able to predict the allergenicity of novel proteins [110,111]. Other strains like Wistar, Hooded Lister, and Piebald Virol Glaxo have been studied, but not commonly used due to the inability to detect quantifiable levels of antigen specific IgE [112].…”

Section: Rodent Models Of Food Allergymentioning

confidence: 99%

“…Like dogs and pigs, also sheep are very similar in size and physiology to people. Sheep have been successfully used as model for peanut allergy [111]. Similarly to other animal models, sheep were sensitized by multiple subcutaneous injections of crude peanut extract and ovalbumin.…”

Section: Other Large Animal Models For Food Allergymentioning

confidence: 99%

See 2 more Smart Citations

Animal Models of Allergic Diseases

Santoro

Marsella

2014

Veterinary Sciences

View full text Add to dashboard Cite

Allergic diseases have great impact on the quality of life of both people and domestic animals. They are increasing in prevalence in both animals and humans, possibly due to the changed lifestyle conditions and the decreased exposure to beneficial microorganisms. Dogs, in particular, suffer from environmental skin allergies and develop a clinical presentation which is very similar to the one of children with eczema. Thus, dogs are a very useful species to improve our understanding on the mechanisms involved in people's allergies and a natural model to study eczema. Animal models are frequently used to elucidate mechanisms of disease and to control for confounding factors which are present in studies with patients with spontaneously occurring disease and to test new therapies that can be beneficial in both species. It has been found that drugs useful in one species can also have benefits in other species highlighting the importance of a comprehensive understanding of diseases across species and the value of comparative studies. The purpose of the current article is to review allergic diseases across species and to focus on how these diseases compare to the counterpart in people.

show abstract

Section: Other Large Animal Models For Food Allergymentioning

confidence: 90%

Section: Rodent Models Of Food Allergymentioning

confidence: 99%

See 1 more Smart Citation

Animal Models of Allergic Diseases

Santoro

Marsella

2014

Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…The greatest challenge in developing animal models is to avoid the default reaction "oral tolerance" in a way that preserves as much as possible of the normal physiology and protein chemistry so that it will predict sensitization in a meaningful way. One way to experimentally overcome oral tolerance is to circumvent the GI tract by dosing intraperitoneally (i.p) or subcutaneously (s.c.), but this has the disadvantage of potentially overestimating sensitization because the digestive tract is circumvented (Ladics et al, 2010). When using the oral route, it is important to bypass the oral cavity by dosing intragastrically (i.g.)…”

Section: Animal Modelsmentioning

confidence: 99%

Approaches to assess IgE mediated allergy risks (sensitization and cross-reactivity) from new or modified dietary proteins

Remington¹,

Broekman

Blom³

et al. 2018

Food and Chemical Toxicology

View full text Add to dashboard Cite

A B S T R A C TThe development and introduction of new dietary protein sources has the potential to improve food supply sustainability. Understanding the potential allergenicity of these new or modified proteins is crucial to ensure protection of public health. Exposure to new proteins may result in de novo sensitization, with or without clinical allergy, or clinical reactions through cross-reactivity.In this paper we review the potential of current methodologies (in silico, in vitro degradation, in vitro IgE binding, animal models and clinical studies) to address these outcomes for risk assessment purposes for new proteins, and especially to identify and characterise the risk of sensitization for IgE mediated allergy from oral exposure. Existing tools and tests are capable of assessing potential crossreactivity. However, there are few possibilities to assess the hazard due to de novo sensitization. The only methods available are in vivo models, but many limitations exist to use them for assessing risk. We conclude that there is a need to understand which criteria adequately define allergenicity for risk assessment purposes, and from these criteria develop a more suitable battery of tests to distinguish between proteins of high and low allergenicity, which can then be applied to assess new proteins with unknown risks.

show abstract

“…It would be extremely useful to have a predictive animal model or cell culture system (e.g., dendritic cells, T cells, and B cells) for accurate evaluation of the sensitizing potential of novel proteins. However, no animal model, cell culture method, complex protease digestion protocol, or computer prediction modeling has yet been demonstrated to accurately predict the risk of sensitization for humans (20,21).…”

Section: Evaluating Potential Allergenicity Of Gmosmentioning

confidence: 99%

GMOs: Are they a regulatory or food safety issue?

Goodman¹

2013

CFW Plexus

View full text Add to dashboard Cite

Review of animal models designed to predict the potential allergenicity of novel proteins in genetically modified crops

Cited by 62 publications

References 95 publications

Animal Models of Allergic Diseases

Animal Models of Allergic Diseases

Approaches to assess IgE mediated allergy risks (sensitization and cross-reactivity) from new or modified dietary proteins

GMOs: Are they a regulatory or food safety issue?

Contact Info

Product

Resources

About