REVIEW ARTICLE Laminitis in the dairy cow: a cell biological approach

Hendry, K. A. K.; MacCallum, Amanda; Knight, Christopher H.; Wilde, Colin J.

doi:10.1017/s002202999700229x

Cited by 25 publications

(21 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Laminitis is associated with impaired synthesis or disturbed chemical binding of keratins, the structural proteins of the hoof, with resultant deterioration of the macromolecular organization that gives the horn mechanical strength [10]. The mechanical strength is determined by the density and diameter of horn tubules [7, 11, 12].…”

Section: Introductionmentioning

confidence: 99%

Partial substitution, with their chelated complexes, of the inorganic zinc, copper and manganese in sow diets reduced the laminitic lesions in the claws and improved the morphometric characteristics of the hoof horn of sows from three Greek herds

et al. 2016

View full text Add to dashboard Cite

BackgroundHoof lesions in sows have been associated with lameness and poor hoof horn quality. The mechanical strength and quality of hoof horn is determined by the density and diameter of horn tubules, which were recently associated with the severity of lesions on the hoof wall of sows. Histologic changes that have previously been described in cases of bovine laminitis, have also been observed in the dermis and epidermis of the sows’ claws. Trace elements, particularly zinc, copper and manganese, occupy important roles as enzyme catalysts in the process of keratin synthesis which determines the quality and the integrity of the hoof epidermis. Therefore, the objective of this study was to investigate the effect of diet supplementation with chelated zinc, copper and manganese, partially substituting their inorganic form, on sow claw health and hoof horn quality assessed by macroscopic, histologic and morphometric examination.ResultsClinically, the total claw lesion score was significantly lower in claws of sows which received the “organic” diet compared to those of sows on the “inorganic” diet. Histologically, lamellar hyperplasia was the most frequently recorded change in the epidermis of the sows’ claws regardless of the diet’s mineral source. The claws of the sows which received the organic diet were more likely to have none or less histologic changes than at least one or more, respectively, compared to those of the sows on the “inorganic” diet. Morphometrically, the density and vertical and horizontal diameters of the horn tubules was significantly higher and smaller, respectively, in the hoof horn of sows which received the “organic” compared to those which received the “inorganic” source diet.ConclusionsPartial substitution of the inorganic zinc, copper and manganese in sows’ diet with their chelated complexes, provided a comparative advantage against a conventional, inorganic mineral source diet, at least under the conditions examined in the current study, in terms of macroscopic, histologic and morphometric criteria, characterizing the health and horn quality status of sows’ hooves.

show abstract

Section: Introductionmentioning

confidence: 99%

Partial substitution, with their chelated complexes, of the inorganic zinc, copper and manganese in sow diets reduced the laminitic lesions in the claws and improved the morphometric characteristics of the hoof horn of sows from three Greek herds

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Keratin is often misunderstood as a single substance even though it is composed of a complex mixture of proteins. The presence of the following substances in keratinizing cells serves as a positive indicator of intense cellular activity: ribonucleic and deoxyribonucleic acid, ascorbic acid, free aldehyde groups, alkaline phosphatase, lipids, glycogen, and glutathione [4, 17]. Keratins are normally differentiated as “soft” or “hard,” corresponding to the products of two apparently.…”

Section: Introductionmentioning

confidence: 99%

Study of Saiga Horn Using High-Performance Liquid Chromatography with Mass Spectrometry

Mikulíková

Romanov

Mikšı́k

et al. 2012

The Scientific World Journal

View full text Add to dashboard Cite

The saiga horns have been investigated the using of modern analytic methods. High-performance liquid chromatography (HPLC) with mass-spectrometric (MS and MS/MS) detection and polyacrylamide gel electrophoresis (PAGE) were used. It could be concluded that basic proteins of the saiga horns are keratins and collagen. The basic representation protein in all samples is keratin type I microfibrillar (from sheep), keratin type II microfibrillar (from sheep), collagen type I (α 1) (from bovine) and collagen type I (α 2) (from bovine). Free amino acids we determined in all samples are nontreated by enzyme.

show abstract

“…9 High levels of a 52-kD protease ("hoofase") were demonstrated in tissues after calving. 10 This finding may explain the high incidence of sole hemorrhages seen 2 to 4 months after calving.…”

Section: Treatment Of Sole Ulcers and White Line Diseasementioning

confidence: 98%