Reversion to normal phenotype induced by SV40 in a spontaneously transformed malignant Chinese hamster cell line

Rayevskaya, Galina B.; Varshaver, Nina B.; Shapiro, N.I.

doi:10.1016/0165-4608(89)90072-1

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2008

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“…Examples of reversion to a normal phenotype of the transformed cells are available. 17 The question of the regulation factors is the other aspect of the adaptation problem. At present epigenetic factors are attributed as regulation factors that induce gene silencing.…”

Section: Resultsmentioning

confidence: 99%

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The Involvement of Different Mobile LINE Copies of Blood Plasma and Extrachromosomal DNA of Liver Cells in Systemic Adaptive Response

Sherlina¹,

Vladimirov²

2008

Annals of the New York Academy of Sciences

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The aim of this work was to investigate the dynamics of the quantity of LINE in the DNA composition of blood plasma and extrachromosomal DNA of liver cells under conditions of either immobilization or exposure to ionizing radiation or a combination of both factors. It has been established that post-stress changes in the quantity of genetic elements may be interpreted as an activation of the mechanisms of retroposition and intercellular transfer of genetic elements that ensure the formation of adaptive responses at the systemic level. The formation of adaptive responses is expressed through the reduction of the content of the low-molecular-weight fraction of the extracellular DNA.

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Section: Resultsmentioning

confidence: 99%

“…It is possible that the regulation of manifestation of gene stress may serve as a key link for the resolution of this problem. Examples of reversion to a normal phenotype of the transformed cells are available 17 …”

Section: Resultsmentioning

confidence: 99%

The Involvement of Different Mobile LINE Copies of Blood Plasma and Extrachromosomal DNA of Liver Cells in Systemic Adaptive Response

Sherlina¹,

Vladimirov²

2008

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

show abstract

Reversion to normal phenotype induced by SV40 in a spontaneously transformed malignant Chinese hamster cell line

Cited by 1 publication

References 19 publications

The Involvement of Different Mobile LINE Copies of Blood Plasma and Extrachromosomal DNA of Liver Cells in Systemic Adaptive Response

The Involvement of Different Mobile LINE Copies of Blood Plasma and Extrachromosomal DNA of Liver Cells in Systemic Adaptive Response

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