Reversible focal ischemia model in the rat: Correlation of somatosensory evoked potentials and cortical neuronal injury

Marinov, Maxim; Schmarov, A.; Natschev, S.; Stamenov, Boyko; Wassmann, H.

doi:10.1080/01616412.1996.11758609

Cited by 7 publications

(3 citation statements)

References 47 publications

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“…Median‐nerve–stimulated SSEP recording has been used in studies of stroke models 28, 39. In these studies, epidural recording was conducted with a silver‐ball electrode while the median nerve was stimulated by needle electrodes adjacent to it.…”

Section: Discussionmentioning

confidence: 99%

“…Stainless‐steel needles were used for recording over the primary somatosensory cortex. The recording electrode was inserted into the scalp just rostral to the coronal suture (0–1 mm anterior to the bregma) and 4–5 mm lateral to the midline on the right hemisphere 28, 39. A reference electrode was inserted into the scalp of the left hemisphere opposite the midline.…”

Section: Methodsmentioning

confidence: 99%

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Electrophysiologic findings and grip strength after nerve injuries in the rat forelimb

Wang

Sorenson²,

Spinner

et al. 2008

Muscle and Nerve

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We developed electrophysiologic methods for testing the three major forelimb nerves as a tool to evaluate motor and sensory recovery in rats. Median, ulnar, or radial nerves were transected and repaired in Sprague-Dawley rats. Compound muscle action potentials (CMAPs) and somatosensory evoked potentials (SSEPs) were recorded preoperatively and at various postoperative intervals. Correlation between grip strength and CMAPs was investigated. Reliable CMAPs were recorded for all three nerves. Median- or ulnar-nerve-derived SSEPs were reliably recorded; radial SSEPs could not be recorded. CMAPs followed typical regeneration patterns after nerve repair. SSEPs showed a consistent peak latency but fluctuating amplitude. Grip strength and median CMAP amplitude correlated positively. We conclude that it is possible to conduct minimally invasive electrophysiologic testing in rat forelimbs. The CMAP is a valid parameter that shows the typical time course of nerve regeneration and reinnervation.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Electrophysiologic findings and grip strength after nerve injuries in the rat forelimb

Wang

Sorenson²,

Spinner

et al. 2008

Muscle and Nerve

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show abstract

“…The somatosensory‐evoked potential (SEP) can be used to predict functional recovery in patients with brain damage (Shah et al ., ). SEP can represent the degree of brain damage in animal experiments (Marinov et al ., ). The motor‐evoked potential (MEP) is another useful electrophysiologic parameter that predicts motor recovery in patients with brain damage, including stroke (Schwarz et al ., ), and has been favorably correlated with gait function in an animal model of stroke (Chen et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Influence of constraint‐induced movement therapy upon evoked potentials in rats with cerebral infarction

Joo

Hyun

Kim

et al. 2012

Eur J of Neuroscience

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Constraint-induced movement therapy (CIMT) is an effective treatment promoting motor recovery of upper extremity function in stroke patients. The objective of the present study was to determine the effect of CIMT on the evoked potentials in rats with focal cerebral cortical ischemia induced by endothelin-1 (ET-1). Thirty rats were randomly assigned to the sham, infarct or CIMT groups. ET-1 was injected stereotaxically into the forelimb area of the cerebral cortex in the dominant hemisphere. Custom-made constraint jackets were applied to limit movement of the unaffected forelimb in the CIMT group. Motor and sensory function of the forelimb was evaluated by a pellet retrieval task and forearm asymmetry test. Electrophysiologic changes were evaluated by motor-evoked potentials (MEPs) and somatosensory-evoked potentials (SEPs). The location and extent of cerebral ischemia were confirmed and compared histologically. The CIMT group showed better recovery in the pellet retrieval task. Forelimb use was more symmetrical in the CIMT group. The waveform of the SEP was reversed and delayed in the infarct group, but it was preserved in the CIMT group with amplitude decrease only. The estimated volume of infarction was smaller in the CIMT group, although statistically not significant. The results demonstrate that CIMT can promote recovery of motor function in focal cerebral cortical infarcts, and that recovery may be related to reorganization of the cerebral neuronal network in the somatosensory pathway.

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Rodent Ischemia Models of Embolism and Ligation of the Middle Cerebral Artery

Borlongan¹,

Nishino²,

Wang³

et al. 2000

Central Nervous System Diseases

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Reversible focal ischemia model in the rat: Correlation of somatosensory evoked potentials and cortical neuronal injury

Cited by 7 publications

References 47 publications

Electrophysiologic findings and grip strength after nerve injuries in the rat forelimb

Electrophysiologic findings and grip strength after nerve injuries in the rat forelimb

Influence of constraint‐induced movement therapy upon evoked potentials in rats with cerebral infarction

Rodent Ischemia Models of Embolism and Ligation of the Middle Cerebral Artery

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