Reversibility of the reproductive toxicity of gossypol in peripubertal bulls

Hassan, Magdy; Smith, Geof W.; Ott, R.S.; Faulkner, Daniel B; Firkins, Lawrence D.; Ehrhart, E. J.; Schaeffer, David J.

doi:10.1016/j.theriogenology.2003.07.007

Cited by 39 publications

(20 citation statements)

References 12 publications

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“…The male antifertility effect is dose and time dependent; in effective doses, gossypol causes infertility by inhibiting sperm motility, decreasing sperm concentrations, inducing specific mitochondrial injury to the sperm tail, and damaging the germinal epithelium [20]. However, such effects are reversible when gossypol is no longer ingested [52]. Furthermore, gossypol administration to male rats did not interfere in the embryonic and fetal development of untreated dam offspring [121].…”

Section: Reproductive Effectsmentioning

confidence: 99%

Gossypol Toxicity from Cottonseed Products

Gadelha

Fonseca

Oloris

et al. 2014

The Scientific World Journal

207

174

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Gossypol is a phenolic compound produced by pigment glands in cotton stems, leaves, seeds, and flower buds (Gossypium spp.). Cottonseed meal is a by-product of cotton that is used for animal feeding because it is rich in oil and proteins. However, gossypol toxicity limits cottonseed use in animal feed. High concentrations of free gossypol may be responsible for acute clinical signs of gossypol poisoning which include respiratory distress, impaired body weight gain, anorexia, weakness, apathy, and death after several days. However, the most common toxic effects is the impairment of male and female reproduction. Another important toxic effect of gossypol is its interference with immune function, reducing an animal's resistance to infections and impairing the efficiency of vaccines. Preventive procedures to limit gossypol toxicity involve treatment of the cottonseed product to reduce the concentration of free gossypol with the most common treatment being exposure to heat. However, free gossypol can be released from the bound form during digestion. Agronomic selection has produced cotton varieties devoid of glands producing gossypol, but these varieties are not normally grown because they are less productive and are more vulnerable to attacks by insects.

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Section: Reproductive Effectsmentioning

confidence: 99%

Gossypol Toxicity from Cottonseed Products

Gadelha

Fonseca

Oloris

et al. 2014

The Scientific World Journal

207

174

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“…Reduced nuclear expression of androgen receptors was observed in Leydig cells, Sertoli cells, and myoid cells from rats fed gossypol-rich cottonseed flour [18]. However, such effects are reversible after the cessation of gossypol exposure [19]. …”

Section: Introductionmentioning

confidence: 99%

Gossypol Promotes Degeneration of Ovarian Follicles in Rats

Gadelha

Macedo

Oloris

et al. 2014

The Scientific World Journal

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The present study aimed to determine if gossypol interferes with ovarian follicles in rats. Twenty-four female Wistar rats were assigned to two equal groups: one control group and the other dosed with gossypol (25 mg/kg/day, subcutaneously) for 15 days. Ovarian follicles were histologically classified according to the stage of development and as normal or atretic. Gossypol treatment reduced the length of estrous with an increase in the duration of the diestrus phase. This compound was responsible for reduced serum levels of T4 and progesterone. Treatment with gossypol was responsible for a significant reduction in the number of normal ovarian follicles and a significant increase in the number of atretic follicles, both in all stages of development. Thus, treatment of rats with gossypol was responsible for reduction in the number of viable follicles and changes in hormone levels that resulted in interference of the estrous cycle.

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“…40 Gossypol impairs spermatogenesis, increases the number of abnormal spermatozoa, and reduces the sperm motility in bulls fed with cottonseed products. 41 Gossypol intoxication can lead to acute death in calves. Clinical signs are dyspnea, abdominal pain, diarrhea, and congestive heart failure if illness is prolonged.…”

Section: Toxic Plantsmentioning

confidence: 99%

Retrospective study of cattle poisonings in California: recognition, diagnosis, and treatment

Varga¹,

Puschner²

2012

VMRR

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Abstract:In this retrospective study all suspect bovine intoxications submitted to the California Animal Health and Food Safety Laboratory between January 1, 2000 and December 31, 2011 were reviewed. A total of 1199 cases were submitted, but a diagnosis of intoxication was only established in 13.5% of cases. In these cases, overexposures to minerals, metals, and poisonous plants were determined as the most commonly diagnosed poisonings in cattle in California. Nitrate/nitrite poisoning was the most commonly diagnosed plant-associated intoxication, followed by gossypol and oleander. This study details the diagnostic challenges and treatment options for the most commonly diagnosed intoxications. To ensure proper treatment and prevention of new cases, accurate diagnosis is necessary, and therefore this review provides an essential tool for the food animal practitioner. Available toxicological analyses are offered at select laboratories, which can be time consuming and expensive, yet the potential for residues in consumed animal products and implications for human health necessitate testing and consultation. Any potential exposure to a toxicant in cattle should be reviewed to determine whether a residue hazard exists. Therapy focuses on immediate removal of the toxicant from the environment and from the gastrointestinal tract. With few antidotes available, most are cost prohibitive to treat numerous affected cattle. In addition, most antidotes will require extra-label drug use and establishment of meat and milk withdrawal times.

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Reversibility of the reproductive toxicity of gossypol in peripubertal bulls

Cited by 39 publications

References 12 publications

Gossypol Toxicity from Cottonseed Products

Gossypol Toxicity from Cottonseed Products

Gossypol Promotes Degeneration of Ovarian Follicles in Rats

Retrospective study of cattle poisonings in California: recognition, diagnosis, and treatment

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