Reversal of premature ventricular complexes induced cardiomyopathy. Influence of concomitant structural heart disease

Abdelhamid, M A; Samir, Rania

doi:10.1016/j.ihj.2017.08.025

Cited by 6 publications

(11 citation statements)

References 25 publications

(48 reference statements)

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“…With regards to the relationship between PVC origin site and EF recovery, a prior study showed a higher incidence of EF recovery of PVC CM in LV ablations compared to RV ablations, though this was not a statistically significant finding 28 . Our study corroborates this with a significant correlation between RV site and lack of EF recovery.…”

Section: Discussionmentioning

confidence: 86%

Cardiac MRI structural and functional predictors of left ventricular ejection fraction recovery following PVC catheter ablation

Mao

Xie

Chamera

et al. 2021

Sci Rep

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Frequent premature ventricular contractions (PVCs) can induce cardiomyopathy (PVC CM). We sought to use cardiac magnetic resonance imaging (CMR) to quantify changes in cardiac structure and function of cardiomyopathy patients following catheter ablation for PVCs. Patients undergoing PVC ablation at the Johns Hopkins Hospital with pre-procedural CMR from 2010 to 2018 were included in this study. CMR Images were analyzed to collect information on cardiac structure and function as well as to quantify scar. Of the total 51 included patients, PVC CM (LVEF < 45%) was observed in 51% (n = 29). Of these, 19 had post-ablation ejection fractions quantified, with 78.9% (n = 15) recovering function. Global longitudinal strain was significantly correlated with LVEF (OR 1.831, p < 0.01) but did not predict recovery of function. RV origin of PVCs was more common in the preserved LVEF group but was also significantly correlated with persistently reduced EF post-ablation in the PVC CM group. Scar burden was not correlated with either cardiac function or post-ablation recovery of function. In this cohort, there were no significant CMR findings to predict subsequent recovery of EF after ablation among those with PVC CM. PVC origin in the RV was associated with persistently reduced LVEF after ablation.

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Section: Discussionmentioning

confidence: 86%

Cardiac MRI structural and functional predictors of left ventricular ejection fraction recovery following PVC catheter ablation

Mao

Xie

Chamera

et al. 2021

Sci Rep

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“…Study characteristics: The electronic search yielded 201 studies. Of the 201, only 11 studies that met the inclusion criteria formed the final dataset for analysis [19][20][21]45,48,[56][57][58][59][60][61]. These studies are relatively recent, published between 2005 [21] and 2018 [61].…”

Section: Resultsmentioning

confidence: 99%

“…Of the 201, only 11 studies that met the inclusion criteria formed the final dataset for analysis [19][20][21]45,48,[56][57][58][59][60][61]. These studies are relatively recent, published between 2005 [21] and 2018 [61]. Except one prospective study [58], the remaining 10 studies adopted a retrospective design [19][20][21]45,48,56,57,[59][60][61].…”

Section: Resultsmentioning

confidence: 99%

“…These studies are relatively recent, published between 2005 [21] and 2018 [61]. Except one prospective study [58], the remaining 10 studies adopted a retrospective design [19][20][21]45,48,56,57,[59][60][61]. Two studies [20,21] grouped patients based on PVC burden; three other studies [58,60,61] grouped patients into two -those with and those without structural heart diseases, while the remaining six studies compared PICM patients with LV dysfunction) and control (those with PVC but without LV dysfunction) [19,45,48,56,57,59].…”

Section: Resultsmentioning

confidence: 99%

“…Except one prospective study [58], the remaining 10 studies adopted a retrospective design [19][20][21]45,48,56,57,[59][60][61]. Two studies [20,21] grouped patients based on PVC burden; three other studies [58,60,61] grouped patients into two -those with and those without structural heart diseases, while the remaining six studies compared PICM patients with LV dysfunction) and control (those with PVC but without LV dysfunction) [19,45,48,56,57,59]. The different objectives of the 11 studies can be subsumed under just two broad objectives: (i) to assess eth efficacy of ablation therapy on LV dysfunction and PVC burden; and (ii) to determine the predictors of PICM on patients with frequent PVCs.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Premature ventricular complexes (PVC)-induced cardiomyopathy: A review and meta-analysis of pathophysiology, diagnosis and clinical management

Albakri¹

2019

Clin Med Invest

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Frequent premature ventricular complexes (PVC) is a common cardiac entity in patients with structural heart disease and PVC-induced cardiomyopathy (PICM). It is also common in asymptomatic patients, where it is considered a benign entity with no prognostic implications. In patients with structural heart disease, the presence of PVCs can result in fatal ventricular arrhythmias. Various cellular and extracellular mechanism as well as risk factors for developing PICM have been suggested but the exact mechanisms remains unclear. The increasing insights into the treatment of ventricular tachyarrhythmias, especially the introduction of radiofrequency catheter ablation in clinical practice has renewed interest in PVCs as predictors of arrhythmias as well as their potential aetiological association with CM. The present paper reviews existing evidence on PICM patients with a focus on prevalence, risk factors, pathophysiology, clinical presentation, concluding with and a meta-analysis and discussion of current diagnostic and treatment criteria.

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Mechanisms, time course and predictability of premature ventricular contractions cardiomyopathy—an update on its development and resolution

et al. 2021

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Reversal of premature ventricular complexes induced cardiomyopathy. Influence of concomitant structural heart disease

Abstract: PVCs elimination by RF ablation results in significant improvement even restoration of LV function regardless of PVC origin, or the presence of concomitant SHD. PVCs burden before and after ablation are the main predictors of LVEF recovery.

Cited by 6 publications

References 25 publications

Cardiac MRI structural and functional predictors of left ventricular ejection fraction recovery following PVC catheter ablation

Cardiac MRI structural and functional predictors of left ventricular ejection fraction recovery following PVC catheter ablation

Premature ventricular complexes (PVC)-induced cardiomyopathy: A review and meta-analysis of pathophysiology, diagnosis and clinical management

Mechanisms, time course and predictability of premature ventricular contractions cardiomyopathy—an update on its development and resolution

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