2016
DOI: 10.18632/aging.100872
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Abstract: Cellular senescence, a state of essentially irreversible proliferation arrest, serves as a potent tumour suppressor mechanism. However, accumulation of senescent cells with chronological age is likely to contribute to loss of tissue and organ function and organismal aging. A crucial biochemical modulator of aging is mTOR; here, we have addressed the question of whether acute mTORC inhibition in near-senescent cells can modify phenotypes of senescence. We show that acute short term treatment of human skin fibro… Show more

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Cited by 81 publications
(76 citation statements)
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References 72 publications
(77 reference statements)
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“…Short-term rapamycin exposure blocks mTORC1 but not mTORC2, in contrast to long-term exposure, which inhibits both complexes. Rapamycin treatment can affect the cell senescence process and SASP, but it does so with differential effects depending on stress or cell type (7,17,22).…”
Section: Introductionmentioning
confidence: 99%
“…mTOR is involved in cellular growth and metabolism and the mTOR complex has been established as a central, evolutionary conserved regulator of longevity 27. Moreover, it has been shown that inhibition of mTOR can reverse cellular senescence, one of the main hallmarks of ageing 28. The fact that one of the upstream activators of mTOR, phosphoinositide-3-kinase, is increased in peripheral blood mononuclear cells of patients with COPD29 30 gives interesting leads to further explore in COPD lungs.…”
Section: Introductionmentioning
confidence: 99%
“…The mammalian target of rapamycin (mTOR) is a major control element of cellular metabolism [53]. Essentially, stimulation of mTOR activates glycolysis to generate not only ATP but also precursors of the many building blocks for cell reproduction.…”
Section: Mtor Inhibitionmentioning
confidence: 99%
“…Accumulation of senescent cells with increased age is believed to contribute to loss of tissue and organ function (5, 6). Oxidative, metabolic, and mechanical stressors also increase with age that can promote tissue injury (711).…”
Section: Increased Lifespan Degenerative Disorders and Cell Injurymentioning
confidence: 99%
“…mTOR is considered a vital component that affects multiple cellular pathways during the aging process (6, 19, 8790). mTOR also is known as the mammalian target of rapamycin and the FK506-binding protein 12-rapamycin complex-associated protein 1 (37).…”
Section: The Mechanistic Target Of Rapamycin (Mtor)mentioning
confidence: 99%