volume 8, issue 2, P231-244 2016
DOI: 10.18632/aging.100872
View full text
Hannah E. Walters, Sylwia Deneka-Hannemann, Lynne S. Cox

Abstract: Cellular senescence, a state of essentially irreversible proliferation arrest, serves as a potent tumour suppressor mechanism. However, accumulation of senescent cells with chronological age is likely to contribute to loss of tissue and organ function and organismal aging. A crucial biochemical modulator of aging is mTOR; here, we have addressed the question of whether acute mTORC inhibition in near-senescent cells can modify phenotypes of senescence. We show that acute short term treatment of human skin fibro…

expand abstract