Reversal activity of the naturally occurring chemosensitizer malagashanine in Plasmodium malaria

Rafatro, Herintsoa; Ramanitrahasimbola, David; Rasoanaivo, Philippe; Ratsimamanga-Urverg, S.; Rakoto-Ratsimamanga, A.; Frappier, François

doi:10.1016/s0006-2952(99)00400-1

Cited by 31 publications

(12 citation statements)

References 16 publications

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“…Data from studies with P. berghei have also shown that in chloroquine resistant strains, GSH can detoxify haemin within the food vacuole, thus precluding its polymerisation and preventing the activity of chloroquine and other quinoline containing drugs [10]. Our study shows that MG inhibits PfGST and it has been found to possess antimalarial activity by increasing the accumulation of CQ inside the parasite [15]. These two properties of MG may then act as a double edged sword in malaria therapy.…”

Section: Discussionsupporting

confidence: 52%

“…The crude alkaloids of Strychnos myrtoides Gilg and Busse, empirically used as an adjuvant to CQ in Malagasy herbal remedies, were found to be practically devoid of intrinsic in vitro and in vivo antimalarial activity. Malagashanine (MG, Figure 1) is the parent compound of a series of Nb,C[2I]-secocuran alkaloids isolated from two Malagasy Strychnos species [15]. It was found to display a good pharmacological profile by enhancing chloroquine (CQ) action in vitro against the CQ-resistant strain Fc29 of P. falciparum in a follow-up study of the empirical uses of Strychnos species as CQ adjuvants in the treatment of chronic malaria [16].…”

Section: R E S E a R C H A R T I C L Ementioning

confidence: 99%

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Glutathione transferase fromPlasmodium falciparum– Interaction with malagashanine and selected plant natural products

Mangoyi

Hayeshi

Ngadjui

et al. 2010

Journal of Enzyme Inhibition and Medicinal Chemistry

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Section: Discussionsupporting

confidence: 52%

Section: R E S E a R C H A R T I C L Ementioning

confidence: 99%

Glutathione transferase fromPlasmodium falciparum– Interaction with malagashanine and selected plant natural products

Mangoyi

Hayeshi

Ngadjui

et al. 2010

Journal of Enzyme Inhibition and Medicinal Chemistry

Self Cite

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“…This surprising cell death effect is likely due to a synthetic lethal effect of HSP90 inhibition on the EBNA1 Gly-Ala repeat domain interaction with infected cell proteasomes (36). Consideration has also been given to potentially unique protein interactions that arise from EBNA1 recruitment of Cdc6, ORC, and MCM to oriP DNA complexes for EBV episome replication (16,34,37,38). EBNA1 also interacts with USP7 and guanosine 5′ monophosphate synthetase to form a complex with DNA to promote EBNA1 oriP-binding (18,39).…”

Section: Discussionmentioning

confidence: 99%

Nucleolin is important for Epstein–Barr virus nuclear antigen 1-mediated episome binding, maintenance, and transcription

Chen

Liu

Cheng

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is essential for EBV episome maintenance, replication, and transcription. These effects are mediated by EBNA1 binding to cognate oriP DNA, which comprise 20 imperfect copies of a 30-bp dyad symmetry enhancer and an origin for DNA replication. To identify cell proteins essential for these EBNA1 functions, EBNA1 associated cell proteins were immune precipitated and analyzed by liquid chromatography-tandem mass spectrometry. Nucleolin (NCL) was identified to be EBNA1 associated. EBNA1's N-terminal 100 aa and NCL's RNA-binding domains were critical for EBNA1/NCL interaction. Lentivirus shRNA-mediated NCL depletion substantially reduced EBNA1 recruitment to oriP DNA, EBNA1-dependent transcription of an EBV oriP luciferase reporter, and EBV genome maintenance in lymphoblastoid cell lines. NCL RNA-binding domain K 429 was critical for ATP and EBNA1 binding. NCL overexpression increased EBNA1 binding to oriP and transcription, whereas NCL K 429 A was deficient. Moreover, NCL silencing impaired lymphoblastoid cell line growth. These experiments reveal a surprisingly critical role for NCL K429 in EBNA1 episome maintenance and transcription, which may be a target for therapeutic intervention.lymphoma | chromatin | oncogenic herpesvirus | nasopharyngeal carcinoma

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“…The asexual erythrocytes' stages of Plasmodium falciparum FcM29-Cameroon, a highly chloroquine-resistant strain were grown continuously in stock cultures by a modification of the methods of Trager and Jensen (1976) using glucose-enriched RPMI 1640 medium, supplemented with 10% human serum at 37 °C as previously described (Rafatro et al, 2000).…”

Section: Parasites Strain and In Vitro Culture Conditionsmentioning

confidence: 99%

Pharmacological screening of some traditionally-used antimalarial plants from the Democratic Republic of Congo compared to their ecological taxonomic equivalence in Madagascar

Ngbolua¹,

Rafatro²,

Rakotoarimanana³

et al. 2012

Int. J. Bio. Chem. Sci

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Hydro-alcoholic extracts of some plant species growing in two different geographical regions (Democratic Republic of Congo and Madagascar) were evaluated for their inhibitory effects on two malaria parasites strains (P. falciparum FcM29 & P. yoelii subsp nigeriensis) and cytotoxicity towards leukaemia P-388 cell lines. Results indicate that, the antiplasmodial activity of tested plants varied geographically. Plants growing in continent ecosystem are more active in vitro while their ecological equivalence inhabiting island ecosystems are more active in vivo. It would be conclude that, the development of phytomedicines from plants of different geographical regions selected by bioguided fractionation would allow the populations to reduce the health care cost. The chemotaxonomic approach has also permitted us to detect moderate antiplasmodial activities in Neobegua mahafaliensis, a plant species not previously reported as antimalarial in the traditional medicine knowlegde of Madagascar. The use of a pharmacological property such as the antimalarial activity, in this study, in order to establish genetic filiations between the plants species is an original approach.

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Reversal activity of the naturally occurring chemosensitizer malagashanine in Plasmodium malaria

Cited by 31 publications

References 16 publications

Glutathione transferase fromPlasmodium falciparum– Interaction with malagashanine and selected plant natural products

Glutathione transferase fromPlasmodium falciparum– Interaction with malagashanine and selected plant natural products

Nucleolin is important for Epstein–Barr virus nuclear antigen 1-mediated episome binding, maintenance, and transcription

Pharmacological screening of some traditionally-used antimalarial plants from the Democratic Republic of Congo compared to their ecological taxonomic equivalence in Madagascar

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