2013
DOI: 10.1590/s1519-69842013000200030
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Abstract: Several epidemiological and molecular studies have confirmed that cervical infection by certain human papillomaviruses (HPV) types is a precursor of the genesis of cervical neoplasia (Gravitt, 2011;Guzmán-Olea et al., 2012). It is yet well elucidated that high risk genotypes lead to the development of cervical cancer and are also associated with other mucosal anogenital, head and neck tumors. The HPV genome is approximately 8 kb in length and is divided into three regions, the non-coding long control region (L… Show more

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Cited by 3 publications
(3 citation statements)
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“…The biological fields have progressed tremendously in the ability to process and interpret large volumes of biological data using computational biology analyses, advancing molecular and structural characterization of bioactive molecules of interest (Schatz et al, 2010;Gabriel et al, 2013). The purpose of the present study was to comparatively assess multiple sequences of the leptin protein in distinct animal species to establish new insights into the conservation degree of biological sequences and evolutionary biology among mammals using computational biology tools.…”
Section: Introductionmentioning
confidence: 99%
“…The biological fields have progressed tremendously in the ability to process and interpret large volumes of biological data using computational biology analyses, advancing molecular and structural characterization of bioactive molecules of interest (Schatz et al, 2010;Gabriel et al, 2013). The purpose of the present study was to comparatively assess multiple sequences of the leptin protein in distinct animal species to establish new insights into the conservation degree of biological sequences and evolutionary biology among mammals using computational biology tools.…”
Section: Introductionmentioning
confidence: 99%
“…In the last decades, bioinformatics has contributed to the development of computational biology tools and their application for several research fields in biology, furthering the understanding of living systems at all scales through the application of computational methods (Schatz, Delcher, Salzberg, 2010;Gabriel, 2012;Gabriel, de Figueiredo, de Farias, 2013). One of these applications is to improve the performance of L. braziliensis, L. major and L. donovani) and other animal species, such as rhesus monkey Macaca mulatta in the chromosomes 2 and 10, respectively (Table 1).…”
Section: Introductionmentioning
confidence: 99%
“…Thus, efforts should be focused on development of comparative protein structure modelling algorithms usable to minimize typical limitations associated with remarkable complexity and variability of transmembrane proteins, such as the number of torsion angles in disallowed regions and exposed hydrophobic residues, hydrogen bonds and exposed polar or charged residues (Zhu et al, 2001). Members of a same family of proteins containing non-synonymous replacements of amino acids have frequently predicted structural and functional differences by computational biology analyses (Gabriel et al, 2013). Substitutions, deletions or insertions of amino acid residues are extensively typical in the outer surface of the proteins, particularly in the loops, structurally variable regions most exposed to the protein.…”
mentioning
confidence: 99%