Retrospective whole-genome comparison of Salmonella enterica serovar Enteritidis from foodborne outbreaks in Southern Brazil

Mascitti, Andrea Karoline; Kipper, Diéssy; Reis, Rafael; Silva, Juliana S. da; Fonseca, André Salvador Kazantzi; Ikuta, Nilo; Tondo, Eduardo César; Lunge, Vagner Ricardo

doi:10.1007/s42770-021-00508-0

Cited by 3 publications

(2 citation statements)

References 48 publications

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“…Diagnostic tools, as well as biosecurity and control measures, were implemented to avoid the high spreading of S. Enteritidis. Monitoring and sanitization plans were introduced in all stages of poultry production, including breeding flocks, hatcheries, broiler flocks, and slaughter establishments [149]. In addition, layers and breeders' flocks have been vaccinated, contributing to a significant reduction in S. Enteritidis contamination in the table egg industry and broiler processing plants [149][150][151][152].…”

Section: Salmonella Enteritidismentioning

confidence: 99%

“…Monitoring and sanitization plans were introduced in all stages of poultry production, including breeding flocks, hatcheries, broiler flocks, and slaughter establishments [149]. In addition, layers and breeders' flocks have been vaccinated, contributing to a significant reduction in S. Enteritidis contamination in the table egg industry and broiler processing plants [149][150][151][152]. In Brazil, preventive measures established by the PNSA were adopted in poultry farms, slaughterhouses, and eggs industries to reduce the prevalence of Salmonella spp.…”

Section: Salmonella Enteritidismentioning

confidence: 99%

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Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil

Kipper

Mascitti

Carli

et al. 2022

Veterinary Sciences

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Salmonella infects poultry, and it is also a human foodborne pathogen. This bacterial genus is classified into several serovars/lineages, some of them showing high antimicrobial resistance (AMR). The ease of Salmonella transmission in farms, slaughterhouses, and eggs industries has made controlling it a real challenge in the poultry-production chains. This review describes the emergence, dissemination, and AMR of the main Salmonella serovars and lineages detected in Brazilian poultry. It is reported that few serovars emerged and have been more widely disseminated in breeders, broilers, and layers in the last 70 years. Salmonella Gallinarum was the first to spread on the farms, remaining as a concerning poultry pathogen. Salmonella Typhimurium and Enteritidis were also largely detected in poultry and foods (eggs, chicken, turkey), being associated with several human foodborne outbreaks. Salmonella Heidelberg and Minnesota have been more widely spread in recent years, resulting in frequent chicken/turkey meat contamination. A few more serovars (Infantis, Newport, Hadar, Senftenberg, Schwarzengrund, and Mbandaka, among others) were also detected, but less frequently and usually in specific poultry-production regions. AMR has been identified in most isolates, highlighting multi-drug resistance in specific poultry lineages from the serovars Typhimurium, Heidelberg, and Minnesota. Epidemiological studies are necessary to trace and control this pathogen in Brazilian commercial poultry production chains.

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Section: Salmonella Enteritidismentioning

confidence: 99%

Section: Salmonella Enteritidismentioning

confidence: 99%

Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil

Kipper

Mascitti

Carli

et al. 2022

Veterinary Sciences

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Recent Evolution and Genomic Profile of Salmonella enterica Serovar Heidelberg Isolates from Poultry Flocks in Brazil

Kipper

Orsi

Carroll

et al. 2021

Appl Environ Microbiol

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Salmonella enterica Heidelberg is a serovar isolated from poultry-producing regions around the World. In Brazil, S. Heidelberg has been frequently detected in poultry flocks, slaughterhouses and chicken. The goal of the present study was to assess the population structure, recent temporal evolution and some important genetic characteristics of S. Heidelberg isolated from Brazilian poultry farms. Phylogenetic analysis of 68 S . Heidelberg genomes sequenced here and additional whole-genomes data from NCBI demonstrated that all isolates from the Brazilian poultry production chain clustered into a monophyletic group, here called S. Heidelberg Brazilian poultry lineage (SH-BPL). Bayesian analysis defined the time of the most recent common ancestor (tMRCA) as 2004 and the overall population size (N e ) constant until 2008, when a ∼10-fold N e increase was observed until circa 2013. SH-BPL presented at least two plasmids with replicons ColpVC ( n =68; 100%), IncX1 ( n =66; 97%), IncA/C2 ( n =65; 95.5%), ColRNAI ( n =43; 63.2%), IncI1 ( n =32; 47%), ColMG828, Col156, IncHI2A, IncHI2, IncQ1, IncX4, IncY and TrfA (each with n<4; <4% each). Antibiotic resistance genes were found, with high frequencies of fosA7 ( n =68; 100%), mdf A ( n =68; 100%), tet(34) ( n =68; 100%), sul2 ( n =64; 94.1%), blaCMY-2 ( n =56; 82.3%) and an overall multi-drug resistance (MDR) profile. Ten pathogenicity islands (SPI1-5, SPI9 and SPI11-14) and 139 virulence genes were also detected. SH-BPL profile was like other previous S. Heidelberg isolates from poultry around the world in the 1990s. In conclusion, the present study demonstrates the recent introduction (2004) and high level of dissemination of an MDR S. Heidelberg lineage in Brazilian poultry operations. IMPORTANCE S. Heidelberg is the most frequent serovar in several broiler farms from the main Brazilian poultry-producing regions. So avian-source foods (mainly chicken carcasses) commercialized in the country and exported to other continents are contaminated with this foodborne pathogen, generating several national and international economic losses. In addition, isolates of this serovar are usually resistant to antibiotics and can cause human invasive and septicemic infection, representing a public health concern. This study demonstrates the use of whole-genome sequencing (WGS) to obtain epidemiological information of one S. Heidelberg lineage highly spread among Brazilian poultry farms. This information will help to define biosecurity measures to control this important Salmonella serovar in Brazilian and worldwide poultry operations.

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Evolution and genomic profile of Salmonella enterica serovar Gallinarum biovar Pullorum isolates from Brazil

Kipper,

De Carli,

de Souza Zanetti

et al. 2023

Avian Diseases

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Retrospective whole-genome comparison of Salmonella enterica serovar Enteritidis from foodborne outbreaks in Southern Brazil

Cited by 3 publications

References 48 publications

Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil

Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil

Recent Evolution and Genomic Profile of Salmonella enterica Serovar Heidelberg Isolates from Poultry Flocks in Brazil

Evolution and genomic profile of Salmonella enterica serovar Gallinarum biovar Pullorum isolates from Brazil

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