Retrospective analysis of forensic toxicology data from 2021 to identify patterns of various forensic cases

Wang, Xinying; Xiang, Ping; Zhang, Sujing; Wang, Jinming; Zhang, Jianhua; Wu, Hejian; Wang, Xin

doi:10.1016/j.forsciint.2023.111683

Cited by 2 publications

(7 citation statements)

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“…13 The 4-methoxyphenylpropan-2-one (PMP2P) was obtained as a yellow oil in 72 % yield. 1 H NMR (500 MHz, CDCl 3 ) δ 7.11 (d, J = 8.7 Hz, 1H), 6.87 (d, J = 8.7 Hz, 1H), 3.79 (s, 1H), 3.63 (s, 1H), 2.13 (s, 1H). 13…”

Section: Batch Synthesis Of Mdp2p and Pmp2pmentioning

confidence: 99%

“…The 1-(3,4-methylenedioxyphenyl)propan-2-one (MDP2P) was obtained as a red oil in 75 % yield. 1 H NMR (500 MHz, CDCl 3 ): δ 6.76 (d, J = 7.9 Hz, 1H), 6.65 (d, J = 1.7 Hz, 1H), 6.63 (dd, J = 7.9, 1.8 Hz, 1H), 5.94 (s, 2H), 3.60 (s, 2H), 2.14 (s, 3H). 13 The 4-methoxyphenylpropan-2-one (PMP2P) was obtained as a yellow oil in 72 % yield.…”

Section: Batch Synthesis Of Mdp2p and Pmp2pmentioning

confidence: 99%

“…Forensic laboratories must ensure the validity of the data presented in their reports. Quality assurance in chemical expertise includes training of technicians, a rigorous sample chain of custody, the use of validated analysis methods, verification of instrument performance, and the use of analytical standards from reliable sources, in addition to internal and external quality controls [1] …”

Section: Introductionmentioning

confidence: 99%

“…Quality assurance in chemical expertise includes training of technicians, a rigorous sample chain of custody, the use of validated analysis methods, verification of instrument performance, and the use of analytical standards from reliable sources, in addition to internal and external quality controls. [1] One of the main targets of forensic analyses is the identification of drugs in seized samples. This identification is commonly performed by comparing the results from chromatography and mass spectrometry analyses to reliable standards.…”

Section: Introductionmentioning

confidence: 99%

“…+ H] + = 194.1180, error: À 2.2 ppm. 4-methoxyamphetamine hydrochloride (PMA.HCl) was obtained as as white crystals in 76 % yield 1. H NMR (500 MHz, D 2 O): δ 7.27 (d, J = 8.5 Hz, 1H), 7.02 (d, J = 8.3 Hz, 1H), 3.84 (s, 1H), 3.59 (m, J = 13.5, 6.7 Hz, 1H), 2.94-2.85 (two dd, 2H), 1.30 (d, J = 6.6 Hz, 1H) 13.…”

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confidence: 99%

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Developing Amphetamine Certified Reference Materials: From Batch and Continuous‐Flow Synthesis to Certification Protocol

Silva,

de Souza,

Garrido

et al. 2023

ChemPlusChem

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Certified reference materials (CRM) of amphetamine derivatives were produced through a simple, rapid and efficient synthesis in both batch and continuous‐flow conditions, accompanied by the development of a comprehensive certification protocol for this class of substances. Our chemistry enabled the synthesis of MDA, MDMA, PMA and PMMA in two steps from safrole and estragole with overall yields of 38‐61% in 48 hours under batch conditions and 61‐65% in 65 minutes under continuous‐flow conditions, followed by the development of a certification protocol for these materials through identity checking, homogeneity, stability, and characterization studies. Furthermore, as result of this work, a very pure CRM of MDA.HCl with 99.1 ± 1.4 g/100 g of certified characterization value was produced. Considering the importance of supplying amphetamine calibrants for public security efforts in Forensic Chemistry, the potential therapeutical applications, and responding to the rising demand for the synthesis of CRM, this work presents a pioneering approach for the production of amphetamine and related compounds.

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Section: Batch Synthesis Of Mdp2p and Pmp2pmentioning

confidence: 99%

Section: Batch Synthesis Of Mdp2p and Pmp2pmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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