Objectives: The antero-lateral thigh free flap (ALT) is conventionally designed as a fasciocutaneous flap (FALT). However, the thickness of the flap can be designed in at least in two more variants: myocutaneous (MYALT), and myofascial (MALT). The aim of this study was to evaluate the use of ALT flap as a universal solution for head and neck soft tissue reconstruction and development of an algorithm for flap selection in different clinical scenarios.Patients and methods: Forty patients, 29 males, 11 females, with mean age of 61.6 years (range 36-77) were enrolled. Thirty-three patients were affected by mucosal squamous cell carcinoma (24 oral cavity, 8 larynx, 1 hypopharynx), four by cutaneous squamous cell carcinoma, two by sarcoma of the orbit, one by adenoid cystic carcinoma of the parotid gland. MALT was used for tongue reconstructions thicker than 2 cm.When vastus lateralis was not thick enough we used MYALT, which was used for bulky head and neck reconstruction requiring mucosa and/or skin. FALT was performed for oral and mucosal defects thinner than 2 cm. We performed 19 MYALT, 11 FALT, and 10 MALT. We proposed ALT reconstruction to all patients requiring soft tissue replacement, for this reason selection bias is excluded. Statistical analysis was conducted to analyze any difference in defect size, flap volume, functional, and cosmetic results. Results: Overall mean follow-up was 18.9 months (range 3-48). Follow-up of single flaps was as follow: MALT 20.3 (range 3-48), MYALT 17.6 (range 4-45), FALT 19.1 (range 3-48), mean time of follow-up was not significant among the three groups (p .82). Mean size of the defect in cm 3 was 188.5 (range 25-495), Mean sizes of the defects were: tongue 177.7 (range 48-360), oral floor/check 128.3 (range 25-432), larynx hypopharynx 315.7 (range 184-495), and maxilla 232.0 (range 224-240).Mean volume difference was significantly different between oral floor defects and