Retrograde Theory in Sialolithiasis Formation

Abstract

S ialolithiasis is a relatively frequent occurrence; however, cases of sialolithiasis originating around a "foreign body" nidus are rare. We describe a patient with submandibular sialolithiasis organized around a vegetal nidus and discuss the etiology of the case.

Microbiomic association between the saliva and salivary stone in patients with sialolithiasis

“…In another study, 15 salivary stones from 12 patients were examined for the presence of bacteria using optical and scanning electron microscopy, and qPCR revealed the presence of bacterial DNA 12 . These findings support the “retrograde theory” proposed by Marchal et al postulating that food, bacteria, and foreign objects migrate from the oral cavity to the salivary duct, and that biofilms could be responsible for stone formation 18 .…”

Submandibular sialolithiasis: Report of six cases

“…Obstruction of the salivary duct due to sialolithiasis is the most frequent etiology of sialadenitis. Hence patients with sialolithiasis can have acute pain due to sialadenitis[6] and this was consistent with most of our cases.…”

Sialolithiasis—Do Early Diagnosis and Removal Minimize Post-Operative Morbidity?

“…In the present study, as reported in the literature [ 5 ], the submandibular was by far more involved compared to the parotid gland. Most (44%) sialoliths were found to be in the hilus of the gland or in the proximal duct system (27%).…”